Abstract
ELECTRICAL measurements in guinea-pig taenia coli indicate that the smooth muscle cell membrane is less permeable to ethanesulphonate (C2H5SO3) and benzene-sulphonate (C6H5SO3) and more permeable to nitrate (NO3) than it is to chloride (Cl). This conclusion is based on the following observations. (a) The membrane is depolarized by about 7 mV when Cl in Krebs solution is replaced with C2H5SO3, and is hyperpolarized by 6 mV with NO3 substitution for Cl (ref. 1). (b) The maximum change of the membrane potential per ten-fold change of the external K concentration is 47 mV in C2H5SO3, 38 mV in Cl and only 15 mV in NO3 (ref. 1). (c) The membrane resistance is higher in C2H5SO3 or C6H5SO3, and lower in NO3 than in Cl Krebs solution (unpublished results of Bülbring and Tomita).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kuriyama, H., J. Physiol., 166, 15 (1963).
Brading, A. F., and Setekleiv, J., J. Physiol., 195, 107 (1968).
Casteels, R., and Kuriyama, H., J. Physiol., 184, 120 (1966).
Casteels, R., thesis, Univ. Oxford (1965).
Conway, E. J., and Moore, P. T., Nature, 156, 170 (1945).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BRADING, A., TOMITA, T. Effect of Anions on the Volume of Smooth Muscle. Nature 218, 276–277 (1968). https://doi.org/10.1038/218276a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/218276a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
