Abstract
IT was initially suggested that vitamin A-deficiency leads to an interference in the biosynthesis of ascorbic acid, because depletion of vitamin A was found to cause a fall in the tissue-levels of ascorbate and diminished urinary ascorbic acid excretion in animals1–3. Mapson4, however, concluded that lowered ascorbic acid-levels in vitamin A-deficient rats is due to inanition only, because he was able to show that following chloretone treatment vitamin A-deficient and pair-fed vitamin A normal rats excrete comparable amounts of ascorbic acid in their urine and that restriction of food intake reduces the urinary ascorbate even in the chloretone-treated normal rats. Results of our preliminary experiments reported here clearly indicate that the synthesis of ascorbic acid in rats is markedly reduced during vitamin A-deficiency.
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SESHADRI SASTRY, P., MALATHI, P., SUBBA RAO, K. et al. Vitamin C Status of Vitamin A-Deficient Rats. Nature 193, 1080–1081 (1962). https://doi.org/10.1038/1931080a0
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DOI: https://doi.org/10.1038/1931080a0
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