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Letters to Nature
Nature 169, 795 - 796 (10 May 1952); doi:10.1038/169795a0

Isolation of a Highly Active Mineralocorticoid from Beef Adrenal Extract

HILARY M. GRUNDY, SYLVIA A. SIMPSON & J. F. TAIT

Courtauld Institute of Biochemistry,
Department of Physics Applied to Medicine, Middlesex Hospital Medical School, London, W.1. Feb. 21.

Grundy, Simpson and Tait1 have shown that most of the activity of beef adrenal extract, as measured by its effect on the mineral metabolism of adrenal-ectomized rats2, was coincident with 11-dehydro-17-hydroxy-corticosterone (cortisone), when the extract was fractionated by Zaffaroni's method of paper chromatography3. From quantitative measurements of the biological activity of the fraction, it was concluded that the activity was due to the presence of a compound other than cortisone.

  1. Grundy, H. M. , Simpson, S. A. , and Tait, J. F. , Lancet, 262, 122 (1952). | ISI |
  2. Simpson, S. A. , and Tait, J. F. , Endocrin. (in the press).
  3. Zaffaroni, A. , Burton, R. B. , and Keutmann, E. H. , Science, 111, 6 (1950). | PubMed | ISI | ChemPort |
  4. Morton, R. A. , "The Application of Absorption Spectra", 47 (London, 1942).
  5. Burton, R. B. , Zaffaroni, A. , and Keutmann, E. H. , J. Biol. Chem., 188, 763 (1951). | PubMed | ISI | ChemPort |
  6. Bush, I. E. , Biochem. J., 50, 370 (1952). | PubMed | ISI | ChemPort |
  7. Zaffaroni, A. , and Burton, R. B. , J. Biol. Chem., 193, 749 (1951). | PubMed | ISI | ChemPort |
  8. Neher, R. , and Wettstein, A. , Helv. Chim. Acta, 34, 2278 (1951). | Article | ISI | ChemPort |



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