Abstract
IN an extension of work upon the growth-inhibitory and carcinogenic effects of 4-aminostilbene1, special attention has been devoted to the influence on these properties of varying the basic side-chain. In one series, the compound 4-NN-di(2-chloroethyl) aminostilbene was of interest as containing the chloroethyl groupings characteristic of the nitrogen mustards. Administration of this substance in relatively high dosage (c. 500 mgm./kgm.) to rats bearing the Walker carcinoma, in an orienting type of experiment already described1, produced an inhibition of tumour-growth considerable in degree but of very brief duration; and pharmacologically the compound appeared, not surprisingly, to be markedly different from the aliphatic chloroethyl -amines on one hand and the aminostilbenes on the other.
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References
Haddow, A., Harris, R. J. C., Kon, G. A. R., and Roe, Edna, M. F., Phil Trans. Roy. Soc., A, 241 147 (1948).
Ross, W. C. J., J. Chem. Soc. (in the press).
Ross, S. D., J. Amer. Chem. Soc., 69, 2982 (1947).
Hanby, W. E., Hartley, G. S., Powell, E. O., and Rydon, H. N., J. Chem. Soc., 519 (1947).
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HADDOW, A., KON, G. & ROSS, W. Effects upon tumours of Various Haloalkylarylamines. Nature 162, 824–825 (1948). https://doi.org/10.1038/162824a0
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DOI: https://doi.org/10.1038/162824a0
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