Browse Articles

Filter By:

  • We develop a method for providing high-quality, holographic, three-dimensional augmented-reality images in a small form factor suitable for incorporation in eyeglass-scale wearables, using high-refraction-index glass waveguides with nanoscale metasurfaces, and incorporating artificial intelligence.

    • Manu Gopakumar
    • Gun-Yeal Lee
    • Gordon Wetzstein
    ArticleOpen Access
  • Efforts to find renewable alternatives to fossil fuels that might enable a carbon-neutral society by 2050 are described, as well as outlining a possible roadmap towards a refinery of the future and evaluating its requirements.

    • Eelco T. C. Vogt
    • Bert M. Weckhuysen
    Perspective
  • An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.

    • Tomer M. Yaron-Barir
    • Brian A. Joughin
    • Jared L. Johnson
    ArticleOpen Access
  • The introduction of chemical short-range disorder substantially affects the crystal structure of layered lithium oxide cathodes, leading to improved charge transfer and structural stability.

    • Qidi Wang
    • Zhenpeng Yao
    • Chenglong Zhao
    Article
  • A completely genetically encoded boronic-acid-containing designer enzyme was created and characterized using X-ray crystallography, high-resolution mass spectrometry and 11B NMR spectroscopy, allowing chemistry that is unknown in nature and currently not possible with small-molecule catalysts.

    • Lars Longwitz
    • Reuben B. Leveson-Gower
    • Gerard Roelfes
    Article
  • Two species of auxotrophic marine bacteria are shown to share precursors to synthesize the essential cofactor vitamin B12, and such ligand cross-feeding may be a common phenomenon in the ocean and other ecosystems.

    • Gerrit Wienhausen
    • Cristina Moraru
    • Meinhard Simon
    Article
  • Detailed analyses of the serotonin receptor 5-HT1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling specificity, efficacy and potency, findings that may facilitate the development of new neuropsychiatric therapeutics.

    • Audrey L. Warren
    • David Lankri
    • Daniel Wacker
    Article
  • Boson sampling using ultracold atoms in a two-dimensional, tunnel-coupled optical lattice is enabled by high-fidelity programmable control with optical tweezers of a large number of atoms trapped in an optical lattice.

    • Aaron W. Young
    • Shawn Geller
    • Adam M. Kaufman
    Article
  • The geological histories of Archaean regions indicate that stabilization of the Earth’s continents and the formation of cratons was driven by continental emergence and subaerial weathering.

    • Jesse R. Reimink
    • Andrew J. Smye
    ArticleOpen Access
  • Biochemical screening and optimization identify small molecules that inhibit the formation of lipoprotein(a), and these inhibitors reduce the levels of Lp(a) in several animal models, suggesting that they could provide a therapeutic option in humans.

    • Nuria Diaz
    • Carlos Perez
    • Laura F. Michael
    ArticleOpen Access
  • Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.

    • Lisa-Maria Needham
    • Carlos Saavedra
    • Randall H. Goldsmith
    Article