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A combined computational and experimental approach is used to determine the DNA sequence preferences of nucleosomes and predict genome-wide nucleosome organization. The yeast genome encodes an intrinsic nucleosome organization, which can explain about 50% of in vivo nucleosome positions.
Modelling of satellite growth as a giant planet accumulates hydrogen gas and rock-ice solids from solar orbit finds that the mass fraction of its satellite system is ∼10−4 and regulated by a balance of two competing processes.
A large-scale genomic strategy to identify genes that regulate self renewal of mouse embryonic stem cells identified seven genes whose depletion negatively affects self renewal, including four which were not known to have an established role in self renewal.
A combination of computer modelling and in vivo transplants demonstrates that the Notch signalling pathway maintains coherent oscillations in gene transcription — silencing the ‘noisy’ gene expression present in the early embryo.
Analysis of Arctic Ocean sediment core spanning more than 50 million years identifies several key features of Arctic climate history — the revised timing of the earliest Arctic cooling events implied by this record coincides with those from Antarctica, supporting arguments that climate change is symmetric about the Earth's polar regions.
Simulations show that the system of three Neptune-mass planets is in a dynamically stable configuration, with theoretical calculations favouring a mainly rocky composition for both inner planets, but a significant gaseous envelope surrounding a rocky/icy core for the outer planet.
A strategy involving high-throughput flow cytometry to monitor protein abundance at single-cell resolution in yeast allows a different view of the cellular response to environmental changes than can be obtained with DNA microarrays.
A three-body gravitational encounter between a binary system — with properties like that of the Pluto–Charon — and Neptune is the most likely explanation for the capture of Triton.