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Image: Rachael Tremlett & David Schilter; Design: Rachael Tremlett

June issue now live!

Read issue 6 of Nature Reviews Chemistry

Latest Reviews

  • Review Article |

    Enzymes that are optimized for low temperatures have characteristics that are distinct from those that operate under milder conditions. This Review examines cold-adapted enzymes and describes how computational studies have highlighted structural and energetic consequences that arise from adaptation to cold environments.

    • Johan Åqvist
    • , Geir Villy Isaksen
    •  & Bjørn Olav Brandsdal
  • Review Article |

    Synaptic vesicles participate in neuronal communication by storing and releasing neurotransmitter molecules. The neurotransmitters can be detected using electrochemistry and mass spectrometry, and vesicle structural elements can be detected by super-resolution microscopy. This Review describes these analytical techniques and how they unravel the mechanisms of cell communication.

    • Nhu T. N. Phan
    • , Xianchan Li
    •  & Andrew G. Ewing
  • Review Article |

    Many methods exist for the recycling of plastic solid waste. Chemical recycling, which can take many forms from high-temperature pyrolysis to mild, solution-based catalytic depolymerization, can afford enormous economic and environmental benefits. This Review covers the state of the art in chemical recycling and the design of high-performance polymers amenable to such processes.

    • AliReza Rahimi
    •  & Jeannette M. García
  • Review Article |

    Although it is a fundamental property of many small molecules, chirality is not widely exploited in materials applications as its benefits are not widely recognized — indeed, the need for stereoselective synthesis may be seen as a disadvantage. In this Review, we highlight recent research in which chirality has had an enabling impact in technological applications.

    • Jochen R. Brandt
    • , Francesco Salerno
    •  & Matthew J. Fuchter
  • Perspective |

    Quadruplex DNA structures were first observed more than 50 years ago, but have only relatively recently attracted interest for their role in the development of cancer. This Perspective considers attempts to selectively bind and stabilize these structures using small molecules, with the aim of developing anticancer therapeutics.

    • Stephen Neidle
  • Review Article |

    Homogenous transition metal electrocatalysts are topical owing to their role in processing electrical energy and mediating the synthesis of chemical fuels. Mechanisms can be uncovered using electrochemical techniques and data analyses, along with complementary spectroscopic techniques. This Review presents case studies highlighting the utility of these methods in the context of electrocatalysis for chemical fuel production.

    • Katherine J. Lee
    • , Noémie Elgrishi
    • , Banu Kandemir
    •  & Jillian L. Dempsey

News & Comment

Current Issue

Volume 1 Issue 6

Image: Rachael Tremlett and David Schilter Design: Rachael Tremlett

Volume 1 Issue 6

Protein–protein interactions help synaptic vesicles bind the cell membrane, to which they fuse prior to releasing their neurotransmitter cargo. Several analytical techniques allow one to probe the nature of the macromolecules involved, as well as the small molecules delivered between cells. Among these techniques is electrochemistry: pictured here is an electrode placed outside the fusion pore, poised to sense dopamine in the form of anodic current signals.

See  Phan, N. T. N., Li, X. & Ewing, A. G. Nat. Rev. Chem. 1, 0048 (2017).