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Mitsiades and colleagues utilize functional genomics data in over 700 cancer cell lines, to identify genes with preferentially essential functions in multiple myeloma, which may represent targets for precision medicine strategies.
Joyce and colleagues use bulk and single-cell profiling of T cell phenotypes in human samples from primary brain tumors and brain metastases as a resource for understanding the biology and therapeutic relevance of the brain tumor microenvironment.
Snijder and colleagues use ex vivo pharmacoscopy and bone marrow composition profiling in a cohort of patients with multiple myeloma to identify tailored therapeutic sensitivities and stratify the cohort into three microenvironmental PhenoGroups.