Volume 1 Issue 6, June 2017

Long-lasting implanted biomaterials

This focus issue highlights strategies for increasing the functional durability of implanted biomaterials.

The cover illustrates a subcutaneously-implanted scaffold for the study and modulation of a pre-metastatic niche (Review Article).

Image by Katie Aguado.

Editorial

Long-lived biomaterials

The design of implantable biomaterials with lasting function is rooted in biomolecular and cellular principles.

Collection:

Implanted biomaterials
Editorial 13 Jun 2017
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News & Views

Immunoengineering: Valet parking for CAR genes

T-cell-binding nanoparticles bypass the complexities of in vitro gene transfer to deliver genes to T cells within the host.

Marcela V. Maus
News & Views 13 Jun 2017
Implanted biomaterials: Neutrophil-mediated vascularization

The recruitment of neutrophils is indispensable for the formation of functional blood vessels in bioengineered grafts.

Cédric Seignez
Mia Phillipson

Collections:

Engineered tissues

Implanted biomaterials
News & Views 13 Jun 2017
Joint implants: An elution solution

An optimized drug-eluting polymer for the surface of articulating artificial joints may make them infection-free.

Noreen J. Hickok

Collections:

Delivery of drugs and biologics

Implanted biomaterials
News & Views 13 Jun 2017
Bioassays: Universal sensitivity booster

A universal ‘add-on’ method based on the ultrafast and localized deposition of polydopamine amplifies the sensitivity of a variety of bioassays for clinical diagnostics.

Shana O. Kelley

Collection:

Technology for diagnostics
News & Views 13 Jun 2017
Implanted scaffolds: Pre-ordered vessels halt ischaemia

Implanted scaffolds bearing 3D-printed parallel endothelialized channels restore blood perfusion in ischaemic hind limbs and infarcted hearts in rodents.

Shahar Ben-Shaul
Shira Landau
Shulamit Levenberg

Collections:

Engineered tissues

Implanted biomaterials
News & Views 13 Jun 2017
Drug delivery: Week-long diabetes therapy

A subcutaneous depot of a diabetes drug fused to a thermosensitive biopolymer leads to blood-glucose control, for over one week after a single injection, in animal models of type-2 diabetes.

Omid Veiseh

Collections:

Delivery of drugs and biologics

Implanted biomaterials
News & Views 13 Jun 2017
Biosensing: CRISPR-powered diagnostics

A CRISPR-associated nuclease that can promiscuously cleave RNAs enables a rapid and cheap test for the single-molecule detection and single-base discrimination of nucleic acids.

Xiaolei Zuo
Chunhai Fan
Hong-Yuan Chen

Collection:

Technology for diagnostics
News & Views 13 Jun 2017

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Reviews

Engineering the pre-metastatic niche

This Review discusses advances in implantable biomaterials that mimic the pre-metastatic niche and regulate the behaviour of tumour cells at the implant site, and their prospects for the detection of metastasis and for therapeutic interventions.

Brian A. Aguado
Grace G. Bushnell
Lonnie D. Shea

Collection:

Implanted biomaterials
Review Article 13 Jun 2017

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Research

One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer

An optimized formulation of glucagon-like peptide-1 recombinantly fused to an elastin-like polypeptide leads to zero-order release kinetics from a subcutaneous depot and to 10 days of glycaemic control in three mouse models of diabetes.

Kelli M. Luginbuhl
Jeffrey L. Schaal
Ashutosh Chilkoti

Collections:

Department of Biomedical Engineering at Duke University

Implanted biomaterials
Article 05 Jun 2017
Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine

A simple and versatile assay that relies on the bioconjugation capabilities and ultrafast and localized deposition of polydopamine can be plugged into common laboratory bioassays to improve their detection sensitivity by orders of magnitude.

Junwei Li
Madison A. Baird
Xiaohu Gao

Collection:

Technology for diagnostics
Article 05 Jun 2017
A fully functional drug-eluting joint implant

In a rabbit model of prosthetic joint infection, optimization of the shape and loading of antibiotic clusters in a polymer implant augments and prolongs antibiotic elution while maintaining implant strength and wear rate.

V. J. Suhardi
D. A. Bichara
E. Oral

Collections:

Delivery of drugs and biologics

Implanted biomaterials
Article 13 Jun 2017
Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks

A comparison of the in vivo engraftment of scaffolds containing either an unassembled suspension of human vascular cells or an assembled network of them shows that non-inflammatory host neutrophils are indispensable mediators of vascularization.

Ruei-Zeng Lin
Chin Nien Lee
Juan M. Melero-Martin

Collections:

Engineered tissues

Implanted biomaterials
Article 13 Jun 2017
3D-printed vascular networks direct therapeutic angiogenesis in ischaemia

3D-printed grafts with geometrically designed and endothelialized vasculature rescue the perfusion of distal tissues in rodent models of hind limb ischaemia and myocardial infarction, preventing capillary loss, muscle atrophy and loss of function.

T. Mirabella
J. W. MacArthur
C. S. Chen

Collections:

Engineered tissues

Implanted biomaterials
Article 01 Jun 2017

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Volume 1 Issue 6, June 2017

Editorial

Long-lived biomaterials

News & Views

Immunoengineering: Valet parking for CAR genes

Implanted biomaterials: Neutrophil-mediated vascularization

Joint implants: An elution solution

Bioassays: Universal sensitivity booster

Implanted scaffolds: Pre-ordered vessels halt ischaemia

Drug delivery: Week-long diabetes therapy

Biosensing: CRISPR-powered diagnostics

Reviews

Engineering the pre-metastatic niche

Research

One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer

Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine

A fully functional drug-eluting joint implant

Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks

3D-printed vascular networks direct therapeutic angiogenesis in ischaemia

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