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A bead-based fluorescence sandwich immunoassay implemented in a custom microfluidic chip can continuously measure glucose and insulin with picomolar sensitivity and sub-second resolution.
The stiffness of the extracellular matrix of gastric tumours reversibly regulates DNA methylation of the promoter region of the oncogenic Yes-associated protein.
A portable device integrating reverse transcription, fast thermocycling and in situ fluorescence detection accurately detects SARS-CoV-2 RNA in patient samples in 17 min.
Patches of transdermal core–shell microneedles, fabricated via additive manufacturing of polymer shells with varying degradability kinetics, enable the preprogrammed burst release of vaccine payloads over a period of a few days to more than a month.
A portable prototype scanner for brain MRI that uses a compact and lightweight permanent rare-earth magnet with a built-in readout field gradient generates clinically relevant images of the brain, as shown in adult volunteers.
An open resource comprising chest computed tomography images and 130 clinical features of 1,521 patients with pneumonia, including COVID-19 pneumonia, facilitates the prediction of morbidity and mortality outcomes via deep learning.
Analysis of physiological and activity data from consumer smartwatches enables real-time detection, often before symptom onset, of COVID-19, as well as other respiratory illnesses and stress inducers.
The systemic administration of erythrocytes with chemokine-encapsulating nanoparticles non-covalently anchored to their surface results in local and systemic tumour suppression in mouse models of lung metastasis.
The magnetically induced accumulation and release of circulating exosomes into infarcted heart tissue from antibody-conjugated magnetic nanoparticles improves angiogenesis and heart function in rat and rabbit models of myocardial infarction.
Antibody and antibody-avidity assays relying on near-infrared-fluorescence amplification by nanostructured plasmonic gold substrates accurately quantify antibodies to SARS-CoV-2 and to common viruses in human serum and saliva.
Chiral photons can accelerate the differentiation of neural stem cells into neurons in vitro and in vivo when DNA-bridged chiral assemblies of gold nanoparticles are tightly entangled with the cells’ cytoskeletal fibres.
An integrated system consisting of conformable piezoelectric devices, three-dimensional digital image correlation, multiphysics modelling and real-time classification algorithms predicts facial kinematics and decodes facial deformations.
Subretinal viral delivery, in mice, of an adenine base editor and a single-guide RNA targeting a nonsense mutation in the Rpe65 gene restores near-normal levels of retinal and visual functions.
Two clinically relevant subtypes of post-traumatic stress disorder and major depressive disorder have been identified via machine learning analyses of functional connectivity patterns in resting-state electroencephalography.
CAR-T cells specific for a neoantigen derived from the driver oncogene nucleophosmin display potent and specific cytotoxic activity in mouse models of human acute myeloid leukaemia.
Deep-learning models for the automated measurement of retinal-vessel calibre in retinal photographs perform comparably to or better than expert graders in associations of measurements of retinal-vessel calibre with cardiovascular risk factors.
The sustained release of a leukaemia-associated epitope peptide and of anti-PD-1 antibody co-encapsulated in degradable microcapsules results in superior therapeutic outcomes in mouse models of leukaemia.