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The intratumoural injection of recombinantly expressed cytokines bound tightly to the common vaccine adjuvant aluminium hydroxide leads to weeks-long retention of the cytokines in the tumours with minimal side effects, as shown in multiple syngeneic mouse models.
Two potent mitophagy inducers, identified and characterized via unsupervised machine learning and a cross-species screening approach, ameliorated the pathology of Alzheimer’s disease in worms and mice.
Functional human atrial myocytes derived from foetal atrial tissue can be massively expanded via a conditional cell-immortalization method, and used in in vitro models of atrial fibrillation.
Optical texture analysis of the retinal nerve fibre layer, via an algorithm integrating thickness and reflectance measurements from standard wide-field optical coherence tomography, outperforms conventional tomographic analysis in the detection of optic neuropathies.
A hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a tendon-adhesive surface on the other side boosts tissue healing in rat models of tendon rupture.