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Deep learning can be used to virtually stain autofluorescence images of unlabelled tissue sections, generating images that are equivalent to the histologically stained versions.
An immunotoxin incorporating an anti-programmed-cell-death-protein-1 (PD-1) single-chain variable fragment selectively eliminates PD-1-expressing cells, and suppresses autoimmunity while preserving adaptive immunity in mouse models of autoimmune disease.
Intravenous delivery of an adenine base editor and a single-guide RNA for the Fah gene can correct an A>G splice-site mutation in an adult mouse model of tyrosinaemia.
A mechanical injector that targets tissue by sensing the loss-of-resistance on encountering softer tissue or a cavity can reliably and precisely deliver liquids to the suprachoroidal space, and to other injection-accessible target sites in the body.
A microfluidic chip with self-assembled 3D herringbone nanopatterns detects, with high sensitivity and specificity, tumour-associated exosomes in few-microlitre plasma samples from patients.
A methodology combining high-throughput nanoparticle synthesis and machine learning can be used to efficiently explore structure–activity relationships for nanomedicines, as shown by spherical nucleic acids functioning as cancer-vaccine candidates.
Body-scale epidermal electronic interfaces for electrophysiological recordings enable the control of a transhumeral prosthesis, long-term electroencephalography, and simultaneous electroencephalography and structural and functional MRI.
Nanosensors of the activity of the protease granzyme B, which release a cleaved fluorescence reporter that filters into urine, enable the early diagnosis of acute transplant rejection in mice.
A computationally designed molecular chaperone inhibits the interaction of normal prions with abnormal isoforms associated with transmissible spongiform encephalopathy, prolongs survival in infected mice and limits symptoms in infected macaques.
Genome-edited human pluripotent stem cells and genome-edited mouse models reveal that combinatorial genetic interactions contribute to the complex genetic heritability of human cardiomyopathy.
Mechanical stress associated with cardiac fibrosis, modelled by a hydrogel with controllable stiffness, affects regulation of the phenotypes of human cardiomyocytes by a portion of the long noncoding RNA ANRIL.
An assay that thermophoretically profiles surface proteins from serum extracellular vesicles labelled with a panel of fluorescent aptamers detects and classifies patients according to cancer type and cancer stage.
A microneedle skin patch with rapidly separable, biodegradable polymer needles continuously releases the contraceptive levonorgestrel for over one month in rats.
A battery-free implantable pressure sensor made entirely of biodegradable materials and based on fringe-field capacitor technology can wirelessly measure arterial blood flow in live rats.
Conductive and elastic hydrogel-based microelectronic arrays with high current-injection density and low interfacial impedance with tissue enable the localized low-voltage electrical stimulation of the sciatic nerve in live mice.
Solid stress generated by brain tumours can cause neurological dysfunction in patients, and this could be countered by administering lithium, according to magnetic resonance imaging of patient brains and mouse models of human brain tumours.