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An in-ear integrated array of sensors for electroencephalography, electrooculography and electrodermal activity and for lactate can be used to concurrently monitor brain states and lactate levels in sweat.
A computationally designed antigen based on the receptor binding domain of the spike protein of sarbecoviruses elicits broad humoral responses against severe acute respiratory syndrome viruses in mice, rabbits and guinea pigs.
Elevated extrinsic tissue-scale forces can drive pathological foreign-body responses to implants, mediated by the Rac2-mediated activation of a subpopulation of mechanoresponsive myeloid cells.
A portable multiplexed assay allows for the rapid detection, via plasmonic-gold-enhanced near-infrared fluorescence, of SARS-CoV-2 RNA at single-copy sensitivity and single-nucleotide specificity for the discrimination of variants of the virus.
A subcutaneously injected hydrogel conjugated with antibodies for interleukin-6 substantially reduces the levels of the cytokine during chimaeric antigen receptor T-cell therapy while maintaining its antitumour efficacy.
Adjuvanting the lipid and the encapsulated messenger RNA-encoded antigen in lipid-nanoparticle mRNA vaccines can enhance the efficiency of mRNA delivery and the activation of the immune responses, as shown for a COVID-19 vaccine in mice.
Established antigen-specific T-cell responses can be suppressed by conjugating the antigen to a glycosylated polymer, as shown in a mouse model of multiple sclerosis and with the suppression of responses to vaccination in non-human primates.
Interpretable machine-learning models can identify clinical-stage monoclonal antibodies with optimal combinations of low off-target binding and low self-association in physiological and antibody-formulation conditions.
A cell-barcoding method leveraging ubiquitous promoters to express small-RNA barcodes modified with direct-capture sequences allows for the longitudinal tracking of the transcriptional states of CAR T cells infused in a mouse model of leukaemia.
RNAs derived from transposable elements and other repeat elements are enriched in the cell-free transcriptome of patients with cancer and can serve as diagnostic signatures.
Subpopulations of functional killer cells in co-culture can be identified and sorted by an assay that detects an intracellular fluorescent protein from lysed cells on the surface of the lysing killer cells.
Measurements of solid stresses in breast tumours by means of intravital microscopy of tumour-embedded hydrogel beads shows that the transmission of solid stresses depends on length scale and on the tumour microenvironment.
Multiplexed imaging of three types of infrared-light-emitting nanoparticle allows for the tracking of a nanoparticle-based cancer vaccine and of the elicited responses from intratumoural antigen-specific T lymphocytes in mice.
The binding specificity of catalytically inactive Cas9 to any pre-defined short sequence of double-stranded DNA can be detected by sensing changes in ionic current as suitably designed barcoded DNA translocates through solid-state nanopores.
Multi-chambered vascularized human cardiac organoids produced under anisotropic stress and integrated with sensors facilitate the study of electro-metabolic coupling in arrythmia.
A computational method for the systematic grafting of animal complementarity-determining regions onto thousands of human frameworks allows for the design of humanized versions of antibodies with improved stability.
Bone-matrix mineralization induces a less proliferative phenotype in breast cancer cells, as shown in collagen-based matrices with adjustable mineralization and in mice with xenografted bone matrices seeded with cancer cells.
Soft conducting polymer electrodes allowing for the continuous and precise localization of a target nerve during microsurgeries led to improved post-operative prognoses after tumour-resection surgeries in rats.
Intuitive thermal perceptions during cold-object grasping with a prosthesis can be restored in a phantom hand through targeted nerve stimulation via a wearable thin-film thermoelectric device with high cooling power density and speed.