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Hydronium ions bordering cancer cells are highly concentrated into a small extracellular region, and in tumour tissue such severely polarized acidity correlates with the expression of monocarboxylate transporters and with the exclusion of cytotoxic T cells.
The intravenous injection of neutrophils bearing discoidal polymer microscale ‘patches’ on their surfaces reduces tumour burden in mice owing to the patch-induced polarization of the neutrophils towards an antitumour phenotype.
Appealing against an editor’s negative decision is likely to be more fruitful when considering the basis of the editorial assessment and offering ways forward.
A machine-learning model trained on interactions between oral drugs and intestinal drug transporters obtained by modulating their expression in intact porcine tissue can be used to predict drug–transporter and drug–drug interactions.
The off-tumour toxicity of a supramolecular bispecific T cell engager can be halted by disengaging T cells from the tumour cells via the disassembly of the supramolecular aggregate through the infusion of the small-molecule drug amantadine.
The delivery of mRNAs into neurons at inflammatory sites in vivo can be enhanced by engineering leucocytes to produce extracellular vesicles incorporating mRNA-packaging retrovirus-like capsids.
Naturally perceived thermal sensations can be evoked as though originating from a prosthetic limb by taking advantage of sensory reinnervation of the residual limb after amputation.
Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus’s spike protein and cells expressing the protein’s receptor.
The inference process of medical-image classifiers can be audited by levering the expertise of physicians to identify medically meaningful features in ‘counterfactual’ images produced via generative AI.
Photoacoustic tomography can image fast haemodynamics by either exploiting the spatial heterogeneity of blood or by leveraging a single laser pulse and a single element functioning as thousands of virtual detectors.
Humanized versions of antibodies with enhanced stability can be designed via the systematic energy-based ranking of computationally grafted non-human complementarity-determining regions onto thousands of human frameworks.
The discovery of antibodies that bind with high affinity to clinically relevant antigens can be sped up by leveraging next-generation sequencing to screen hundreds of millions of antibody–antigen interactions.
Pharmaceutical companies continue to advocate for the use of in vitro models towards the reduction of animal use in drug discovery and development while acknowledging that further advancements are needed to heighten the models’ current state of readiness.
Cellular encapsulation holds promise for immunosuppression-free pancreatic islet transplantation. However, long-term graft survival remains a challenge, especially at the subcutaneous site. We harnessed temporary, controlled, inflammation-induced neovascularization to create a modified subcutaneous cavity that supports long-term survival and function of a customized islet encapsulation device without immunosuppression.
Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.