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Water exchange through the transmembrane channel aquaporin-4 can be measured by conventional dynamic-contrast-enhanced magnetic resonance imaging and is a sensitive biomarker of the proliferation of gliomas and their resistance to chemotherapy.
Comparisons of neural recordings across time, across subsets of neurons and across individuals requires the alignment of low-dimensional latent representations.
Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood–brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions.
An anti-CD98 antibody with pH-dependent binding elicits tumour-specific Fc-mediated anti-tumour activity in multiple xenograft and syngeneic tumour models established in CD98-humanized mice.
Neuroectodermal cells produced via the direct reprogramming of human astrocytes can be induced to form spinal-cord organoids with functional neurons specific to the dorsal and ventral domains.
Transmembrane water-efflux rate is a sensitive biomarker of the expression of aquaporin-4, and can be measured via conventional dynamic-contrast-enhanced magnetic resonance imaging, as shown in animals and in patients with gliomas.
Graph deep learning applied to multiplexed immunofluorescence data from tumour microenvironments reveals spatial cellular structures that are indicative of cancer prognosis.
A graph neural network that leverages spatial protein profiles in tissue specimens to model tumour microenvironments as local subgraphs captures distinctive cellular interactions associated with differential clinical outcomes.
Genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions can make them surrogate receptor agonists with longer half-lives in circulation and enhanced penetration of the blood–brain barrier.
Off-the-shelf microphones and earbud components connected to a smartphone can be as effective as an expensive clinical-grade device at measuring otoacoustic emissions to screen for hearing loss.
A low-cost probe for otoacoustic emissions made from off-the-shelf earbuds and microphones performs similarly to a clinical-grade device, as shown via a clinical study involving 201 paediatric ears screened for hearing loss.
A hydrogel-based metamaterial undergoing shape and optical changes amplified in response to antibody-mediated biorecognition can be used to molecularly profile extracellular vesicles in ascites fluid from patients with cancer.
A tomographic method for the location of photon pairs originating from the annihilation of positron–electron pairs produced by high-energy X-rays in tissue could allow for the monitoring of radiotherapy dosing.
Closed-loop optogenetic stimulation with excitatory opsins enables the precise manipulation of neural dynamics in brain slices from transgenic mice and in anaesthetized non-human primates.
Radionuclide brachytherapy delivered via an injectable biopolymer depot conjugated with iodine-131 and combined with systemically delivered paclitaxel induced the complete regression of multiple subcutaneous and orthotopic pancreatic tumours in mice.