Generalist large language models can elevate the quality and efficiency of academic writing.

A patient-centred system that leverages the analysis of sweat via wearable sensors may better support the management of patients with substance-use disorders.

A framework for integrating continuous therapeutic monitoring and the development of AI for clinical care may improve patient and health-system outcomes by tightening feedback loops between patient health, clinical interactions and the development of AI models.

This Perspective discusses progress in the development of robotic capsules for oral drug delivery and the challenges of realizing sophisticated multifunctional robotic pills that can function as closed-loop systems.

Bioluminescent sources can be detected with magnetic resonance imaging by leveraging the light-mediated activation of vascular cells expressing a photosensitive bacterial enzyme that causes alterations in local haemodynamic contrast.

Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher humoral and adaptive immune responses in mice.

Transthoracic ultrasound localization microscopy enables super-resolution imaging of myocardial microvasculature and haemodynamics in patients with impaired myocardial function using data acquired within a breath hold.

Durable and robust lymph-node expansion is associated with the efficacy of therapeutic vaccination, as shown in mice immunized via a biomaterial-based vaccine.

Intramyocardial injection of synthetic mRNA coding for the embryonic T-box transcription factor 18 gene generates rate-adaptive cardiac pacing and limits innate and inflammatory immune responses, as shown in rodents and pigs.

The removal of terminal sialic acid residues on glycans at the T-cell–tumour-cell interface via a sialidase fused to a bispecific T-cell engager enhances the susceptibility of solid cancers to T-cell-mediated cytolysis.

The widening range of strategies to alter the phenotypes and functions of mammalian cells is a boon for their biomedical applications.

Applied biomedical research needs more of them to be more broadly useful, reproducible and robust.

A patient-centred system that leverages the analysis of sweat via wearable sensors may better support the management of patients with substance-use disorders.

Generalist large language models can elevate the quality and efficiency of academic writing.

Appealing against an editor’s negative decision is likely to be more fruitful when considering the basis of the editorial assessment and offering ways forward.

A handy go-between may soon assist authors and editors.