Ella Marushchenko

Large-scale production of therapeutic extracellular vesicles

The January issue highlights cellular nanoporation as a method for the large-scale generation of extracellular vesicles encapsulating therapeutic mRNAs.

Latest Research

  • Article |

    Physiological modelling of first-pass metabolism using data from a robotic instrument that fluidically links relevant organ chips predicts human pharmacokinetic parameters for orally administered nicotine and for intravenously injected cisplatin.

    • Anna Herland
    • , Ben M. Maoz
    • , Debarun Das
    • , Mahadevabharath R. Somayaji
    • , Rachelle Prantil-Baun
    • , Richard Novak
    • , Michael Cronce
    • , Tessa Huffstater
    • , Sauveur S. F. Jeanty
    • , Miles Ingram
    • , Angeliki Chalkiadaki
    • , David Benson Chou
    • , Susan Marquez
    • , Aaron Delahanty
    • , Sasan Jalili-Firoozinezhad
    • , Yuka Milton
    • , Alexandra Sontheimer-Phelps
    • , Ben Swenor
    • , Oren Levy
    • , Kevin K. Parker
    • , Andrzej Przekwas
    •  & Donald E. Ingber
  • Article |

    A system employing liquid-handling robotics and an integrated mobile microscope enables the automated culture, sample collection and in situ microscopy imaging of up to ten fluidically coupled organ chips within a standard tissue-culture incubator.

    • Richard Novak
    • , Miles Ingram
    • , Susan Marquez
    • , Debarun Das
    • , Aaron Delahanty
    • , Anna Herland
    • , Ben M. Maoz
    • , Sauveur S. F. Jeanty
    • , Mahadevabharath R. Somayaji
    • , Morgan Burt
    • , Elizabeth Calamari
    • , Angeliki Chalkiadaki
    • , Alexander Cho
    • , Youngjae Choe
    • , David Benson Chou
    • , Michael Cronce
    • , Stephanie Dauth
    • , Toni Divic
    • , Jose Fernandez-Alcon
    • , Thomas Ferrante
    • , John Ferrier
    • , Edward A. FitzGerald
    • , Rachel Fleming
    • , Sasan Jalili-Firoozinezhad
    • , Thomas Grevesse
    • , Josue A. Goss
    • , Tiama Hamkins-Indik
    • , Olivier Henry
    • , Chris Hinojosa
    • , Tessa Huffstater
    • , Kyung-Jin Jang
    • , Ville Kujala
    • , Lian Leng
    • , Robert Mannix
    • , Yuka Milton
    • , Janna Nawroth
    • , Bret A. Nestor
    • , Carlos F. Ng
    • , Blakely O’Connor
    • , Tae-Eun Park
    • , Henry Sanchez
    • , Josiah Sliz
    • , Alexandra Sontheimer-Phelps
    • , Ben Swenor
    • , Guy Thompson II
    • , George J. Touloumes
    • , Zachary Tranchemontagne
    • , Norman Wen
    • , Moran Yadid
    • , Anthony Bahinski
    • , Geraldine A. Hamilton
    • , Daniel Levner
    • , Oren Levy
    • , Andrzej Przekwas
    • , Rachelle Prantil-Baun
    • , Kevin K. Parker
    •  & Donald E. Ingber
  • Article |

    A vascularized human bone-marrow-on-a-chip improves the maintenance of patient-derived CD34+ cells, and recapitulates clinically relevant aspects of bone marrow injury as well as key haematopoietic defects of patients with a rare genetic disorder.

    • David B. Chou
    • , Viktoras Frismantas
    • , Yuka Milton
    • , Rhiannon David
    • , Petar Pop-Damkov
    • , Douglas Ferguson
    • , Alexander MacDonald
    • , Özge Vargel Bölükbaşı
    • , Cailin E. Joyce
    • , Liliana S. Moreira Teixeira
    • , Arianna Rech
    • , Amanda Jiang
    • , Elizabeth Calamari
    • , Sasan Jalili-Firoozinezhad
    • , Brooke A. Furlong
    • , Lucy R. O’Sullivan
    • , Carlos F. Ng
    • , Youngjae Choe
    • , Susan Marquez
    • , Kasiani C. Myers
    • , Olga K. Weinberg
    • , Robert P. Hasserjian
    • , Richard Novak
    • , Oren Levy
    • , Rachelle Prantil-Baun
    • , Carl D. Novina
    • , Akiko Shimamura
    • , Lorna Ewart
    •  & Donald E. Ingber
  • Article |

    A method that quantifies signal reductions in proton magnetic resonance spectroscopy resulting from the replacement of 1H with 2H after the administration of a deuterated substrate can be used to monitor the turnover of cellular metabolites in vivo.

    • Laurie J. Rich
    • , Puneet Bagga
    • , Neil E. Wilson
    • , Mitchell D. Schnall
    • , John A. Detre
    • , Mohammad Haris
    •  & Ravinder Reddy
  • Article |

    Optimized adeno-associated viruses delivering split cytosine base editors and adenine base editors with trans-splicing inteins can edit brain, liver, retina, heart and skeletal-muscle tissues at therapeutically relevant efficiencies.

    • Jonathan M. Levy
    • , Wei-Hsi Yeh
    • , Nachiket Pendse
    • , Jessie R. Davis
    • , Erin Hennessey
    • , Rossano Butcher
    • , Luke W. Koblan
    • , Jason Comander
    • , Qin Liu
    •  & David R. Liu

News & Comment

  • Comment |

    As an intermediary between cells and scaffolding biomaterials, the extracellular matrix secreted by the cells offers challenges and opportunities for the design and fabrication of engineered tissues.

    • Ulrich Blache
    • , Molly M. Stevens
    •  & Eileen Gentleman
  • Editorial |

    The editing of single DNA bases in the genome is being optimized for higher editing precision and versatility.

  • News & Views |

    Negatively charged nanoparticles of about 50 nm in size permit the oral delivery of insulin and other peptide drugs by temporally enhancing the permeability of the intestinal wall.

    • Per Artursson
    •  & Patrik Lundquist
  • News & Views |

    In an adult mouse model of tyrosinaemia, a base editor correcting an A-to-G splice-site mutation in the Fah gene restores the translation of the functional enzyme, promoting the repopulation of the liver with the corrected cells.

    • Kiran Musunuru
  • News & Views |

    An injectable biomaterial vaccine encapsulating antigens associated with acute myeloid leukaemia, dendritic-cell-targeting pro-inflammatory cytokines and an adjuvant protects mice from the disease.

    • Guojun Chen
    •  & Zhen Gu
  • News & Views |

    The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.

    • Monique A. J. van Eijndhoven
    • , S. Rubina Baglio
    •  & D. Michiel Pegtel

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