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Exemplary output from a fiber tractography analysis of one patient with bipolar disorder. A regularized streamline algorithm to virtually reconstruct fibres between the subgenual cingulate and the amygdalo-hippocampal region was used. Reconstructed fibres connecting left subgenual cingulate (red) and left amygdalo-hippocampal complex (light brown) in dark blue. Reconstructed fibres connecting the left amygdalohippocampal complex to the rest of the brain are depicted in light blue. For more information on this topic, please refer to article by Houenou et al on pages 1001–1010.