ADVANCE ONLINE PUBLICATION

The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
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June 20 2017

Original Articles

Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo

R Diaz-Espinoza, R Morales, L Concha-Marambio, I Moreno-Gonzalez, F Moda and C Soto

Mol Psychiatry advance online publication, June 20, 2017; doi:10.1038/mp.2017.84

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder Open

B P F Rutten, E Vermetten, C H Vinkers, G Ursini, N P Daskalakis, E Pishva, L de Nijs, L C Houtepen, L Eijssen, A E Jaffe, G Kenis, W Viechtbauer, D van den Hove, K G Schraut, K-P Lesch, J E Kleinman, T M Hyde, D R Weinberger, L Schalkwyk, K Lunnon, J Mill, H Cohen, R Yehuda, D G Baker, A X Maihofer, C M Nievergelt, E Geuze and M P M Boks

Mol Psychiatry advance online publication, June 20, 2017; doi:10.1038/mp.2017.120

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex

D Scheggia, E Zamberletti, N Realini, M Mereu, G Contarini, V Ferretti, F Managò, G Margiani, R Brunoro, T Rubino, M A De Luca, D Piomelli, D Parolaro and F Papaleo

Mol Psychiatry advance online publication, June 20, 2017; doi:10.1038/mp.2017.126

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia Open

S Teng, P A Thomson, S McCarthy, M Kramer, S Muller, J Lihm, S Morris, D C Soares, W Hennah, S Harris, L M Camargo, V Malkov, A M McIntosh, J K Millar, D H Blackwood, K L Evans, I J Deary, D J Porteous and W R McCombie

Mol Psychiatry advance online publication, June 20, 2017; doi:10.1038/mp.2017.115

Corrigendum

Autism spectrum disorders and autistic traits share genetics and biology Open

J Bralten, K J van Hulzen, M B Martens, T E Galesloot, A Arias Vasquez, L A Kiemeney, J K Buitelaar, J W Muntjewerff, B Franke and G Poelmans

Mol Psychiatry advance online publication, June 20, 2017; doi:10.1038/mp.2017.127

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June 13 2017

Guest Editorial

Toward fine-grained phenotyping of suicidal behavior: the role of suicidal subtypes Open

J A Bernanke, B H Stanley and M A Oquendo

Mol Psychiatry advance online publication, June 13, 2017; doi:10.1038/mp.2017.123

Original Articles

The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans

D A Gonzalez, T Jia, J H Pinzón, S F Acevedo, S A Ojelade, B Xu, N Tay, S Desrivières, J L Hernandez, T Banaschewski, C Büchel, A L W Bokde, P J Conrod, H Flor, V Frouin, J Gallinat, H Garavan, P A Gowland, A Heinz, B Ittermann, M Lathrop, J-L Martinot, T Paus, M N Smolka, the IMAGEN Consortium, A R Rodan, G Schumann and A Rothenfluh

Mol Psychiatry advance online publication, June 13, 2017; doi:10.1038/mp.2017.112

Prenatal fever and autism risk Open

M Hornig, M A Bresnahan, X Che, A F Schultz, J E Ukaigwe, M L Eddy, D Hirtz, N Gunnes, K K Lie, P Magnus, S Mjaaland, T Reichborn-Kjennerud, S Schjølberg, A-S Øyen, B Levin, E S Susser, C Stoltenberg and W I Lipkin

Mol Psychiatry advance online publication, June 13, 2017; doi:10.1038/mp.2017.119

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June 6 2017

Immediate Communication

Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α

Z D Kabir, A Che, D K Fischer, R C Rice, B K Rizzo, M Byrne, M J Glass, N V De Marco Garcia and A M Rajadhyaksha

Mol Psychiatry advance online publication, June 6, 2017; doi:10.1038/mp.2017.124

Original Article

Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition Open

V Warrier, K L Grasby, F Uzefovsky, R Toro, P Smith, B Chakrabarti, J Khadake, E Mawbey-Adamson, N Litterman, J-J Hottenga, G Lubke, D I Boomsma, N G Martin, P K Hatemi, S E Medland, D A Hinds, T Bourgeron and S Baron-Cohen

Mol Psychiatry advance online publication, June 6, 2017; doi:10.1038/mp.2017.122

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May 30 2017

Immediate Communication

Tau-dependent suppression of adult neurogenesis in the stressed hippocampus

C Dioli, P Patrício, R Trindade, L G Pinto, J M Silva, M Morais, E Ferreiro, S Borges, A Mateus-Pinheiro, A J Rodrigues, N Sousa, J M Bessa, L Pinto and I Sotiropoulos

Mol Psychiatry advance online publication, May 30, 2017; doi:10.1038/mp.2017.103

Original Articles

The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling

M E Cahill, D M Walker, A M Gancarz, Z J Wang, C K Lardner, R C Bagot, R L Neve, D M Dietz and E J Nestler

Mol Psychiatry advance online publication, May 30, 2017; doi:10.1038/mp.2017.116

Acute ketamine administration corrects abnormal inflammatory bone markers in major depressive disorder

B Kadriu, P W Gold, D A Luckenbaugh, M S Lener, E D Ballard, M J Niciu, I D Henter, L T Park, R T De Sousa, P Yuan, R Machado-Vieira and C A Zarate Jr

Mol Psychiatry advance online publication, May 30, 2017; doi:10.1038/mp.2017.109

Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects

Y Kim, P Giusti-Rodriguez, J J Crowley, J Bryois, R J Nonneman, A K Ryan, C R Quackenbush, M D Iglesias-Ussel, P H Lee, W Sun, F P-M de Villena and P F Sullivan

Mol Psychiatry advance online publication, May 30, 2017; doi:10.1038/mp.2017.111

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May 23 2017

Letter to the Editor

Blocking CRMP2 SUMOylation reverses neuropathic pain

A Moutal, E T Dustrude, T M Largent-Milnes, T W Vanderah, M Khanna and R Khanna

Mol Psychiatry advance online publication, May 23, 2017; doi:10.1038/mp.2017.117

Original Articles

ASD restricted and repetitive behaviors associated at 17q21.33: genes prioritized by expression in fetal brains

R M Cantor, L Navarro, H Won, R L Walker, J K Lowe and D H Geschwind

Mol Psychiatry advance online publication, May 23, 2017; doi:10.1038/mp.2017.114

Vortioxetine reduces BOLD signal during performance of the N-back working memory task: a randomised neuroimaging trial in remitted depressed patients and healthy controls Open

J Smith, M Browning, S Conen, R Smallman, J Buchbjerg, K G Larsen, C K Olsen, S R Christensen, G R Dawson, J F Deakin, P Hawkins, R Morris, G Goodwin and C J Harmer

Mol Psychiatry advance online publication, May 23, 2017; doi:10.1038/mp.2017.104

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May 16 2017

Original Articles

Autism spectrum disorders and autistic traits share genetics and biology Open

J Bralten, K J van Hulzen, M B Martens, T E Galesloot, A Arias Vasquez, L A Kiemeney, J K Buitelaar, J W Muntjewerff, B Franke and G Poelmans

Mol Psychiatry advance online publication, May 16, 2017; doi:10.1038/mp.2017.98

Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer’s disease dementia Open

K Chiotis, L Saint-Aubert, E Rodriguez-Vieitez, A Leuzy, O Almkvist, I Savitcheva, M Jonasson, M Lubberink, A Wall, G Antoni and A Nordberg

Mol Psychiatry advance online publication, May 16, 2017; doi:10.1038/mp.2017.108

The microbiome regulates amygdala-dependent fear recall Open

A E Hoban, R M Stilling, G Moloney, F Shanahan, T G Dinan, G Clarke and J F Cryan

Mol Psychiatry advance online publication, May 16, 2017; doi:10.1038/mp.2017.100

Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls

T Moberget, N T Doan, D Alnæs, T Kaufmann, A Córdova-Palomera, T V Lagerberg, J Diedrichsen, E Schwarz, M Zink, S Eisenacher, P Kirsch, E G Jönsson, H Fatouros-Bergman, L Flyckt, KaSP, G Pergola, T Quarto, A Bertolino, D Barch, A Meyer-Lindenberg, I Agartz, O A Andreassen and L T Westlye

Mol Psychiatry advance online publication, May 16, 2017; doi:10.1038/mp.2017.106

Elevation of p11 in lateral habenula mediates depression-like behavior Open

J-S Seo, P Zhong, A Liu, Z Yan and P Greengard

Mol Psychiatry advance online publication, May 16, 2017; doi:10.1038/mp.2017.96

PET imaging of dopamine-D2 receptor internalization in schizophrenia

J J Weinstein, E van de Giessen, R J Rosengard, X Xu, N Ojeil, G Brucato, R B Gil, L S Kegeles, M Laruelle, M Slifstein and A Abi-Dargham

Mol Psychiatry advance online publication, May 16, 2017; doi:10.1038/mp.2017.107

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May 9 2017

Original Articles

Investigating the neuroimmunogenic architecture of schizophrenia

R Birnbaum, A E Jaffe, Q Chen, J H Shin, BrainSeq Consortium, J E Kleinman, T M Hyde and D R Weinberger

Mol Psychiatry advance online publication, May 9, 2017; doi:10.1038/mp.2017.89

Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours

A C Ferreira, T Santos, B Sampaio-Marques, A Novais, S D Mesquita, P Ludovico, L Bernardino, M Correia-Neves, N Sousa, J A Palha, J C Sousa and F Marques

Mol Psychiatry advance online publication, May 9, 2017; doi:10.1038/mp.2017.95

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

E Jorgenson, K K Thai, T J Hoffmann, L C Sakoda, M N Kvale, Y Banda, C Schaefer, N Risch, J Mertens, C Weisner and H Choquet

Mol Psychiatry advance online publication, May 9, 2017; doi:10.1038/mp.2017.101

Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects

A Kanzari, C Bourcier-Lucas, A Freyssin, D N Abrous, N Haddjeri and G Lucas

Mol Psychiatry advance online publication, May 9, 2017; doi:10.1038/mp.2017.94

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential

A J Sandweiss, M I McIntosh, A Moutal, R Davidson-Knapp, J Hu, A K Giri, T Yamamoto, V J Hruby, R Khanna, T M Largent-Milnes and T W Vanderah

Mol Psychiatry advance online publication, May 9, 2017; doi:10.1038/mp.2017.102

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia

R Tao, K N Davis, C Li, J H Shin, Y Gao, A E Jaffe, M C Gondré-Lewis, D R Weinberger, J E Kleinman and T M Hyde

Mol Psychiatry advance online publication, May 9, 2017; doi:10.1038/mp.2017.105

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May 2 2017

Expert Review

Connectome imaging for mapping human brain pathways Open

Y Shi and A W Toga

Mol Psychiatry advance online publication, May 2, 2017; doi:10.1038/mp.2017.92

Original Articles

A relationship between the aldosterone–mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans Open

E G Aoun, V A Jimenez, L F Vendruscolo, N A R Walter, E Barbier, A Ferrulli, C L Haass-Koffler, P Darakjian, M R Lee, G Addolorato, M Heilig, R Hitzemann, G F Koob, K A Grant and L Leggio

Mol Psychiatry advance online publication, May 2, 2017; doi:10.1038/mp.2017.97

Genetic risk for schizophrenia and psychosis in Alzheimer disease

M A A DeMichele-Sweet, E A Weamer, L Klei, D T Vrana, D J Hollingshead, H J Seltman, R Sims, T Foroud, I Hernandez, S Moreno-Grau, L Tárraga, M Boada, A Ruiz, J Williams, R Mayeux, O L Lopez, E L Sibille, M I Kamboh, B Devlin and R A Sweet

Mol Psychiatry advance online publication, May 2, 2017; doi:10.1038/mp.2017.81

Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group Open

D P Hibar, L T Westlye, N T Doan, N Jahanshad, J W Cheung, C R K Ching, A Versace, A C Bilderbeck, A Uhlmann, B Mwangi, B Krämer, B Overs, C B Hartberg, C Abé, D Dima, D Grotegerd, E Sprooten, E Bøen, E Jimenez, F M Howells, G Delvecchio, H Temmingh, J Starke, J R C Almeida, J M Goikolea, J Houenou, L M Beard, L Rauer, L Abramovic, M Bonnin, M F Ponteduro, M Keil, M M Rive, N Yao, N Yalin, P Najt, P G Rosa, R Redlich, S Trost, S Hagenaars, S C Fears, S Alonso-Lana, T G M van Erp, T Nickson, T M Chaim-Avancini, T B Meier, T Elvsåshagen, U K Haukvik, W H Lee, A H Schene, A J Lloyd, A H Young, A Nugent, A M Dale, A Pfennig, A M McIntosh, B Lafer, B T Baune, C J Ekman, C A Zarate, C E Bearden, C Henry, C Simhandl, C McDonald, C Bourne, D J Stein, D H Wolf, D M Cannon, D C Glahn, D J Veltman, E Pomarol-Clotet, E Vieta, E J Canales-Rodriguez, F G Nery, F L S Duran, G F Busatto, G Roberts, G D Pearlson, G M Goodwin, H Kugel, H C Whalley, H G Ruhe, J C Soares, J M Fullerton, J K Rybakowski, J Savitz, K T Chaim, M Fatjó-Vilas, M G Soeiro-de-Souza, M P Boks, M V Zanetti, M C G Otaduy, M S Schaufelberger, M Alda, M Ingvar, M L Phillips, M J Kempton, M Bauer, M Landén, N S Lawrence, N E M van Haren, N R Horn, N B Freimer, O Gruber, P R Schofield, P B Mitchell, R S Kahn, R Lenroot, R Machado-Vieira, R A Ophoff, S Sarró, S Frangou, T D Satterthwaite, T Hajek, U Dannlowski, U F Malt, V Arolt, W F Gattaz, W C Drevets, X Caseras, I Agartz, P M Thompson and O A Andreassen for the ENIGMA Bipolar Disorder Working Group

Mol Psychiatry advance online publication, May 2, 2017; doi:10.1038/mp.2017.73

A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling

T M Hsu, E E Noble, C M Liu, A M Cortella, V R Konanur, A N Suarez, D J Reiner, J D Hahn, M R Hayes and S E Kanoski

Mol Psychiatry advance online publication, May 2, 2017; doi:10.1038/mp.2017.91

Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory

T N Huynh, E Santini, E Mojica, A E Fink, B S Hall, R N Fetcho, L Grosenick, K Deisseroth, J E LeDoux, C Liston and E Klann

Mol Psychiatry advance online publication, May 2, 2017; doi:10.1038/mp.2017.99

Exocytosis-related genes and response to methylphenidate treatment in adults with ADHD

B S da Silva, R B Cupertino, D L Rovaris, J B Schuch, D B Kappel, D Müller, C E Bandeira, M M Victor, R G Karam, N R Mota, L A Rohde, V Contini, E H Grevet and C H D Bau

Mol Psychiatry advance online publication, May 2, 2017; doi:10.1038/mp.2017.90

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April 25 2017

Original Articles

Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear

A Asok, A Draper, A F Hoffman, J Schulkin, C R Lupica and J B Rosen

Mol Psychiatry advance online publication, April 25, 2017; doi:10.1038/mp.2017.79

Brain age predicts mortality Open

J H Cole, S J Ritchie, M E Bastin, M C Valdés Hernández, S Muñoz Maniega, N Royle, J Corley, A Pattie, S E Harris, Q Zhang, N R Wray, P Redmond, R E Marioni, J M Starr, S R Cox, J M Wardlaw, D J Sharp and I J Deary

Mol Psychiatry advance online publication, April 25, 2017; doi:10.1038/mp.2017.62

Autism spectrum disorders: a meta-analysis of executive function Open

E A Demetriou, A Lampit, D S Quintana, S L Naismith, Y J C Song, J E Pye, I Hickie and A J Guastella

Mol Psychiatry advance online publication, April 25, 2017; doi:10.1038/mp.2017.75

Largest GWAS of PTSD (N=20070) yields genetic overlap with schizophrenia and sex differences in heritability Open

L E Duncan, A Ratanatharathorn, A E Aiello, L M Almli, A B Amstadter, A E Ashley-Koch, D G Baker, J C Beckham, L J Bierut, J Bisson, B Bradley, C-Y Chen, S Dalvie, L A Farrer, S Galea, M E Garrett, J E Gelernter, G Guffanti, M A Hauser, E O Johnson, R C Kessler, N A Kimbrel, A King, N Koen, H R Kranzler, M W Logue, A X Maihofer, A R Martin, M W Miller, R A Morey, N R Nugent, J P Rice, S Ripke, A L Roberts, N L Saccone, J W Smoller, D J Stein, M B Stein, J A Sumner, M Uddin, R J Ursano, D E Wildman, R Yehuda, H Zhao, M J Daly, I Liberzon, K J Ressler, C M Nievergelt and K C Koenen

Mol Psychiatry advance online publication, April 25, 2017; doi:10.1038/mp.2017.77

A novel 5HT3 receptor–IGF1 mechanism distinct from SSRI-induced antidepressant effects

M Kondo, Y Koyama, Y Nakamura and S Shimada

Mol Psychiatry advance online publication, April 25, 2017; doi:10.1038/mp.2017.87

Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects Open

S-X Li, Y Han, L-Z Xu, K Yuan, R-X Zhang, C-Y Sun, D-F Xu, M Yuan, J-H Deng, S-Q Meng, X-J Gao, Q Wen, L-J Liu, W-L Zhu, Y-X Xue, M Zhao, J Shi and L Lu

Mol Psychiatry advance online publication, April 25, 2017; doi:10.1038/mp.2017.85

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

N Mellios, D A Feldman, S D Sheridan, J P K Ip, S Kwok, S K Amoah, B Rosen, B A Rodriguez, B Crawford, R Swaminathan, S Chou, Y Li, M Ziats, C Ernst, R Jaenisch, S J Haggarty and M Sur

Mol Psychiatry advance online publication, April 25, 2017; doi:10.1038/mp.2017.86

Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability

M L Miller, Y Ren, H Szutorisz, N A Warren, C Tessereau, G Egervari, A Mlodnicka, M Kapoor, B Chaarani, C V Morris, G Schumann, H Garavan, A M Goate, M J Bannon, IMAGEN Consortium, J M Halperin and Y L Hurd

Mol Psychiatry advance online publication, April 25, 2017; doi:10.1038/mp.2017.80

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April 18 2017

Original Articles

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells Open

N Gunhanlar, G Shpak, M van der Kroeg, L A Gouty-Colomer, S T Munshi, B Lendemeijer, M Ghazvini, C Dupont, W J G Hoogendijk, J Gribnau, F M S de Vrij and S A Kushner

Mol Psychiatry advance online publication, April 18, 2017; doi:10.1038/mp.2017.56

The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders: a delineation of four potential pathways to illness

K S Kendler, H Ohlsson, R S E Keefe, K Sundquist and J Sundquist

Mol Psychiatry advance online publication, April 18, 2017; doi:10.1038/mp.2017.78

Perisomatic changes in h-channels regulate depressive behaviors following chronic unpredictable stress Open

C S Kim, D H Brager and D Johnston

Mol Psychiatry advance online publication, April 18, 2017; doi:10.1038/mp.2017.28

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs Open

M-X Li, H-L Zheng, Y Luo, J-G He, W Wang, J Han, L Zhang, X Wang, L Ni, H-Y Zhou, Z-L Hu, P-F Wu, Y Jin, L-H Long, H Zhang, G Hu, J-G Chen and F Wang

Mol Psychiatry advance online publication, April 18, 2017; doi:10.1038/mp.2017.76

Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse Open

D C Ung, G Iacono, H Méziane, E Blanchard, M-A Papon, M Selten, J-R van Rhijn, R Montjean, J Rucci, S Martin, A Fleet, M-C Birling, S Marouillat, R Roepman, M Selloum, A Lux, R-A Thépault, P Hamel, K Mittal, J B Vincent, O Dorseuil, H G Stunnenberg, P Billuart, N Nadif Kasri, Y Hérault and F Laumonnier

Mol Psychiatry advance online publication, April 18, 2017; doi:10.1038/mp.2017.39

Brain-derived neurotrophic factor Val66Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study

S-M Wei, E B Baller, P D Kohn, J S Kippenhan, B Kolachana, S J Soldin, D R Rubinow, P J Schmidt and K F Berman

Mol Psychiatry advance online publication, April 18, 2017; doi:10.1038/mp.2017.72

A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder

L Yang, S Chang, Q Lu, Y Zhang, Z Wu, X Sun, Q Cao, Y Qian, T Jia, B Xu, Q Duan, Y Li, K Zhang, G Schumann, D Liu, J Wang, Y Wang and L Lu

Mol Psychiatry advance online publication, April 18, 2017; doi:10.1038/mp.2017.74

Corrigendum

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment FREE

M M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, A Renblom, S C Sim, E M Peñas-Lledó, P Courtet, A Llerena, B T Baune, D J de Quervain, A Papassotiropoulos, R F Tyndale, E B Binder, U Dannlowski and M Ingelman-Sundberg

Mol Psychiatry advance online publication, April 18, 2017; doi:10.1038/mp.2017.93

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April 11 2017

Expert Review

Neuronal plasticity and neurotrophic factors in drug responses Open

E Castrén and H Antila

Mol Psychiatry advance online publication, April 11, 2017; doi:10.1038/mp.2017.61

Original Articles

Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression

I Esterlis, N DellaGioia, R H Pietrzak, D Matuskey, N Nabulsi, C G Abdallah, J Yang, C Pittenger, G Sanacora, J H Krystal, R V Parsey, R E Carson and C DeLorenzo

Mol Psychiatry advance online publication, April 11, 2017; doi:10.1038/mp.2017.58

Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families

R Harripaul, N Vasli, A Mikhailov, M A Rafiq, K Mittal, C Windpassinger, T I Sheikh, A Noor, H Mahmood, S Downey, M Johnson, K Vleuten, L Bell, M Ilyas, F S Khan, V Khan, M Moradi, M Ayaz, F Naeem, A Heidari, I Ahmed, S Ghadami, Z Agha, S Zeinali, R Qamar, H Mozhdehipanah, P John, A Mir, M Ansar, L French, M Ayub and J B Vincent

Mol Psychiatry advance online publication, April 11, 2017; doi:10.1038/mp.2017.60

The nucleus reuniens: a key node in the neurocircuitry of stress and depression

V Kafetzopoulos, N Kokras, I Sotiropoulos, J F Oliveira, H Leite-Almeida, A Vasalou, V M Sardinha, Z Papadopoulou-Daifoti, O F X Almeida, K Antoniou, N Sousa and C Dalla

Mol Psychiatry advance online publication, April 11, 2017; doi:10.1038/mp.2017.55

EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction Open

D Mielenz, M Reichel, T Jia, E B Quinlan, T Stöckl, M Mettang, D Zilske, E Kirmizi-Alsan, P Schönberger, M Praetner, S E Huber, D Amato, M Schwarz, P Purohit, S Brachs, J Spranger, A Hess, C Büttner, A B Ekici, F Perez-Branguli, B Winner, V Rauschenberger, T Banaschewski, A L W Bokde, C Büchel, P J Conrod, S Desrivières, H Flor, V Frouin, J Gallinat, H Garavan, P Gowland, A Heinz, J-L Martinot, H Lemaitre, F Nees, T Paus, M N Smolka, IMAGEN Consortium, A Schambony, T Bäuerle, V Eulenburg, C Alzheimer, A Lourdusamy, G Schumann and C P Müller

Mol Psychiatry advance online publication, April 11, 2017; doi:10.1038/mp.2017.63

A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression

P Riva-Posse, K S Choi, P E Holtzheimer, A L Crowell, S J Garlow, J K Rajendra, C C McIntyre, R E Gross and H S Mayberg

Mol Psychiatry advance online publication, April 11, 2017; doi:10.1038/mp.2017.59

Structural alterations within cerebellar circuitry are associated with general liability for common mental disorders

A L Romer, A R Knodt, R Houts, B D Brigidi, T E Moffitt, A Caspi and A R Hariri

Mol Psychiatry advance online publication, April 11, 2017; doi:10.1038/mp.2017.57

Top

April 4 2017

Original Articles

Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline Open

D R Bach, A Tzovara and J Vunder

Mol Psychiatry advance online publication, April 4, 2017; doi:10.1038/mp.2017.65

A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies Open

G Banks, G Lassi, A Hoerder-Suabedissen, F Tinarelli, M M Simon, A Wilcox, P Lau, T N Lawson, S Johnson, A Rutman, M Sweeting, J E Chesham, A R Barnard, N Horner, H Westerberg, L B Smith, Z Molnár, M H Hastings, R A Hirst, V Tucci and P M Nolan

Mol Psychiatry advance online publication, April 4, 2017; doi:10.1038/mp.2017.54

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

R C Culverhouse, N L Saccone, A C Horton, Y Ma, K J Anstey, T Banaschewski, M Burmeister, S Cohen-Woods, B Etain, H L Fisher, N Goldman, S Guillaume, J Horwood, G Juhasz, K J Lester, L Mandelli, C M Middeldorp, E Olié, S Villafuerte, T M Air, R Araya, L Bowes, R Burns, E M Byrne, C Coffey, W L Coventry, K A B Gawronski, D Glei, A Hatzimanolis, J-J Hottenga, I Jaussent, C Jawahar, C Jennen-Steinmetz, J R Kramer, M Lajnef, K Little, H M zu Schwabedissen, M Nauck, E Nederhof, P Petschner, W J Peyrot, C Schwahn, G Sinnamon, D Stacey, Y Tian, C Toben, S Van der Auwera, N Wainwright, J-C Wang, G Willemsen, I M Anderson, V Arolt, C Åslund, G Bagdy, B T Baune, F Bellivier, D I Boomsma, P Courtet, U Dannlowski, E J C de Geus, J F W Deakin, S Easteal, T Eley, D M Fergusson, A M Goate, X Gonda, H J Grabe, C Holzman, E O Johnson, M Kennedy, M Laucht, N G Martin, M R Munafò, K W Nilsson, A J Oldehinkel, C A Olsson, J Ormel, C Otte, G C Patton, B W J H Penninx, K Ritchie, M Sarchiapone, J M Scheid, A Serretti, J H Smit, N C Stefanis, P G Surtees, H Völzke, M Weinstein, M Whooley, J I Nurnberger Jr, N Breslau and L J Bierut

Mol Psychiatry advance online publication, April 4, 2017; doi:10.1038/mp.2017.44

Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia

R Hadar, L Bikovski, M L Soto-Montenegro, J Schimke, P Maier, S Ewing, M Voget, F Wieske, T Götz, M Desco, C Hamani, J Pascau, I Weiner and C Winter

Mol Psychiatry advance online publication, April 4, 2017; doi:10.1038/mp.2017.52

Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety

D B McKim, M D Weber, A Niraula, C M Sawicki, X Liu, B L Jarrett, K Ramirez-Chan, Y Wang, R M Roeth, A D Sucaldito, C G Sobol, N Quan, J F Sheridan and J P Godbout

Mol Psychiatry advance online publication, April 4, 2017; doi:10.1038/mp.2017.64

A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice Open

D P Ryan, K S Henzel, B L Pearson, M E Siwek, A Papazoglou, L Guo, K Paesler, M Yu, R Müller, K Xie, S Schröder, L Becker, L Garrett, S M Hölter, F Neff, I Rácz, B Rathkolb, J Rozman, G Ehninger, M Klingenspor, T Klopstock, E Wolf, W Wurst, A Zimmer, H Fuchs, V Gailus-Durner, M Hrabě de Angelis, K Sidiropoulou, M Weiergräber, Y Zhou and D Ehninger

Mol Psychiatry advance online publication, April 4, 2017; doi:10.1038/mp.2017.53

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March 28 2017

Original Articles

Perinatal risk factors in Tourette’s and chronic tic disorders: a total population sibling comparison study Open

G Brander, M Rydell, R Kuja-Halkola, L Fernández de la Cruz, P Lichtenstein, E Serlachius, C Rück, C Almqvist, B M D'Onofrio, H Larsson and D Mataix-Cols

Mol Psychiatry advance online publication, March 28, 2017; doi:10.1038/mp.2017.31

A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse

M H Galinato, J W Lockner, M J Fannon-Pavlich, J C Sobieraj, M C Staples, S S Somkuwar, A Ghofranian, S Chaing, A I Navarro, A Joea, B W Luikart, K D Janda, C Heyser, G F Koob and C D Mandyam

Mol Psychiatry advance online publication, March 28, 2017; doi:10.1038/mp.2017.46

Preventing intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department: a proof-of-concept randomized controlled trial Open

L Iyadurai, S E Blackwell, R Meiser-Stedman, P C Watson, M B Bonsall, J R Geddes, A C Nobre and E A Holmes

Mol Psychiatry advance online publication, March 28, 2017; doi:10.1038/mp.2017.23

Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning

A E Lyall, O Pasternak, D G Robinson, D Newell, J W Trampush, J A Gallego, M Fava, A K Malhotra, K H Karlsgodt, M Kubicki and P R Szeszko

Mol Psychiatry advance online publication, March 28, 2017; doi:10.1038/mp.2017.43

Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study

J E Verhoeven, D Révész, M Picard, E E Epel, O M Wolkowitz, K A Matthews, B W J H Penninx and E Puterman

Mol Psychiatry advance online publication, March 28, 2017; doi:10.1038/mp.2017.48

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March 21 2017

Review

Pluripotent stem cells in neuropsychiatric disorders Open

M A Soliman, F Aboharb, N Zeltner and L Studer

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.40

Perspective

Genomic resources for the study of neuropsychiatric disorders

G Senthil, T Dutka, L Bingaman and T Lehner

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.29

Original Articles

A rare missense variant in RCL1 segregates with depression in extended families Open

N Amin, F M S de Vrij, M Baghdadi, R W W Brouwer, J G J van Rooij, O Jovanova, A G Uitterlinden, A Hofman, H L A Janssen, S Darwish Murad, R Kraaij, J Stedehouder, M C G N van den Hout, J M Kros, W F J van IJcken, H Tiemeier, S A Kushner and C M van Duijn

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.49

Neuroanatomic, epigenetic and genetic differences in monozygotic twins discordant for attention deficit hyperactivity disorder

Y-C Chen, G Sudre, W Sharp, F Donovan, S C Chandrasekharappa, N Hansen, L Elnitski and P Shaw

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.45

Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies

L B Chibnik, C C White, S Mukherjee, T Raj, L Yu, E B Larson, T J Montine, C D Keene, J Sonnen, J A Schneider, P K Crane, J M Shulman, D A Bennett and P L De Jager

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.20

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder Open

M V Lombardo, H M Moon, J Su, T D Palmer, E Courchesne and T Pramparo

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.15

Identification of a novel, fast-acting GABAergic antidepressant

K M J McMurray, M J Ramaker, A M Barkley-Levenson, P S Sidhu, P K Elkin, M K Reddy, M L Guthrie, J M Cook, V H Rawal, L A Arnold, S C Dulawa and A A Palmer

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.14

Early life adversity and telomere length: a meta-analysis

K K Ridout, M Levandowski, S J Ridout, L Gantz, K Goonan, D Palermo, L H Price and A R Tyrka

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.26

Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders Open

L Yan, A Shamir, M Skirzewski, E Leiva-Salcedo, O B Kwon, I Karavanova, D Paredes, O Malkesman, K R Bailey, D Vullhorst, J N Crawley and A Buonanno

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.22

Erratum

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny FREE

M E Wimmer, L A Briand, B Fant, L A Guercio, A C Arreola, H D Schmidt, S Sidoli, Y Han, B A Garcia and R C Pierce

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.71

Corrigendum

Genetic contributions to self-reported tiredness Open

V Deary, S P Hagenaars, S E Harris, W D Hill, G Davies, D C M Liewald, International Consortium for Blood Pressure GWAS, CHARGE consortium Aging and Longevity Group, CHARGE consortium Inflammation Group, A M McIntosh, C R Gale and I J Deary

Mol Psychiatry advance online publication, March 21, 2017; doi:10.1038/mp.2017.70

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March 14 2017

Original Articles

Cafeteria diet and probiotic therapy: cross talk among memory, neuroplasticity, serotonin receptors and gut microbiota in the rat

J E Beilharz, N O Kaakoush, J Maniam and M J Morris

Mol Psychiatry advance online publication, March 14, 2017; doi:10.1038/mp.2017.38

Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders Open

P Devanna, X S Chen, J Ho, D Gajewski, S D Smith, A Gialluisi, C Francks, S E Fisher, D F Newbury and S C Vernes

Mol Psychiatry advance online publication, March 14, 2017; doi:10.1038/mp.2017.30

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay

M R Lee, K B Scheidweiler, X X Diao, F Akhlaghi, A Cummins, M A Huestis, L Leggio and B B Averbeck

Mol Psychiatry advance online publication, March 14, 2017; doi:10.1038/mp.2017.27

CSF GABA is reduced in first-episode psychosis and associates to symptom severity Open

F Orhan, H Fatouros-Bergman, M Goiny, A Malmqvist, F Piehl, S Cervenka, K Collste, P Victorsson, C M Sellgren, L Flyckt, S Erhardt and G Engberg

Mol Psychiatry advance online publication, March 14, 2017; doi:10.1038/mp.2017.25

The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner

S C Page, G R Hamersky, R A Gallo, M D Rannals, N E Calcaterra, M N Campbell, B Mayfield, A Briley, B N Phan, A E Jaffe and B J Maher

Mol Psychiatry advance online publication, March 14, 2017; doi:10.1038/mp.2017.37

Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial

J L Roffman, L J Petruzzi, A S Tanner, H E Brown, H Eryilmaz, N F Ho, M Giegold, N J Silverstein, T Bottiglieri, D S Manoach, J W Smoller, D C Henderson and D C Goff

Mol Psychiatry advance online publication, March 14, 2017; doi:10.1038/mp.2017.41

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March 7 2017

Original Articles

Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness

R Bansal, D J Hellerstein and B S Peterson

Mol Psychiatry advance online publication, March 7, 2017; doi:10.1038/mp.2017.34

Brain structural and functional signatures of impulsive–compulsive behaviours in Parkinson’s disease

F Imperiale, F Agosta, E Canu, V Markovic, A Inuggi, M Jecmenica-Lukic, A Tomic, M Copetti, S Basaia, V S Kostic and M Filippi

Mol Psychiatry advance online publication, March 7, 2017; doi:10.1038/mp.2017.18

A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus

R Polimanti, J Kaufman, H Zhao, H R Kranzler, R J Ursano, R C Kessler, J Gelernter and M B Stein

Mol Psychiatry advance online publication, March 7, 2017; doi:10.1038/mp.2017.24

Risk alleles of genes with monoallelic expression are enriched in gain-of-function variants and depleted in loss-of-function variants for neurodevelopmental disorders

V Savova, S Vinogradova, D Pruss, A A Gimelbrant and L A Weiss

Mol Psychiatry advance online publication, March 7, 2017; doi:10.1038/mp.2017.13

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February 28 2017

Original Articles

The familial co-aggregation of ASD and ADHD: a register-based cohort study Open

L Ghirardi, I Brikell, R Kuja-Halkola, C M Freitag, B Franke, P Asherson, P Lichtenstein and H Larsson

Mol Psychiatry advance online publication, February 28, 2017; doi:10.1038/mp.2017.17

Reduction of smoking urges with intranasal insulin: a randomized, crossover, placebo-controlled clinical trial

A Hamidovic, M Khafaja, V Brandon, J Anderson, G Ray, A M Allan and M R Burge

Mol Psychiatry advance online publication, February 28, 2017; doi:10.1038/mp.2016.234

In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence

A T Hillmer, C M Sandiego, J Hannestad, G A Angarita, A Kumar, E M McGovern, Y Huang, K C O'Connor, R E Carson, S S O'Malley and K P Cosgrove

Mol Psychiatry advance online publication, February 28, 2017; doi:10.1038/mp.2017.10

Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242

M Ranganathan, N DeMartinis, B Huguenel, F Gaudreault, M M Bednar, C L Shaffer, S Gupta, J Cahill, M A Sherif, J Mancuso, L Zumpano and D C D’Souza

Mol Psychiatry advance online publication, February 28, 2017; doi:10.1038/mp.2017.6

Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium

S Stern, R Santos, M C Marchetto, A P D Mendes, G A Rouleau, S Biesmans, Q-W Wang, J Yao, P Charnay, A G Bang, M Alda and F H Gage

Mol Psychiatry advance online publication, February 28, 2017; doi:10.1038/mp.2016.260

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February 21 2017

Original Articles

Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice

A Busquets-Garcia, E Soria-Gómez, B Redon, Y Mackenbach, M Vallée, F Chaouloff, M Varilh, G Ferreira, P-V Piazza and G Marsicano

Mol Psychiatry advance online publication, February 21, 2017; doi:10.1038/mp.2017.4

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny

M E Wimmer, L A Briand, B Fant, L A Guercio, A C Arreola, H D Schmidt, S Sidoli, Y Han, B A Garcia and R C Pierce

Mol Psychiatry advance online publication, February 21, 2017; doi:10.1038/mp.2017.8

Corrigendum

Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia FREE

P H Lee, J T Baker, A J Holmes, N Jahanshad, T Ge, J -Y Jung, Y Cruz, D S Manoach, D P Hibar, J Faskowitz, K L McMahon, G I de Zubicaray, N H Martin, M J Wright, D Öngür, R Buckner, J Roffman, P M Thompson and J W Smoller

Mol Psychiatry advance online publication, February 21, 2017; doi:10.1038/mp.2017.42

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February 14 2017

Original Articles

Genetic contributions to self-reported tiredness Open

V Deary, S P Hagenaars, S E Harris, W D Hill, G Davies, D C M Liewald, A M McIntosh, C R Gale and I J Deary

Mol Psychiatry advance online publication, February 14, 2017; doi:10.1038/mp.2017.5

Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior Open

M A Hutchison, X Gu, M F Adrover, M R Lee, T S Hnasko, V A Alvarez and W Lu

Mol Psychiatry advance online publication, February 14, 2017; doi:10.1038/mp.2017.7

Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens

A Martínez-Rivera, J Hao, T F Tropea, T P Giordano, M Kosovsky, R C Rice, A Lee, R L Huganir, J Striessnig, N A Addy, S Han and A M Rajadhyaksha

Mol Psychiatry advance online publication, February 14, 2017; doi:10.1038/mp.2017.9

Corrigenda

JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche Open

H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson, H van Praag and E T Coffey

Mol Psychiatry advance online publication, February 14, 2017; doi:10.1038/mp.2017.21

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder FREE

J Song, S E Bergen, A Di Florio, R Karlsson, A Charney, D M Ruderfer, E A Stahl, Members of the International Cohort Collection for Bipolar Disorder (ICCBD), K D Chambert, J L Moran, K Gordon-Smith, L Forty, E K Green, I Jones, L Jones, E M Scolnick, P Sklar, J W Smoller, P Lichtenstein, C Hultman, N Craddock and M Landén

Mol Psychiatry advance online publication, February 14, 2017; doi:10.1038/mp.2016.246

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February 7 2017

Original Articles

Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development Open

T Dang, W Y Duan, B Yu, D L Tong, C Cheng, Y F Zhang, W Wu, K Ye, W X Zhang, M Wu, B B Wu, Y An, Z L Qiu and B L Wu

Mol Psychiatry advance online publication, February 7, 2017; doi:10.1038/mp.2016.253

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

J Deckert, H Weber, C Villmann, T B Lonsdorf, J Richter, M Andreatta, A Arias-Vasquez, L Hommers, L Kent, C Schartner, S Cichon, C Wolf, N Schaefer, C R von Collenberg, B Wachter, R Blum, D Schümann, R Scharfenort, J Schumacher, A J Forstner, C Baumann, M A Schiele, S Notzon, P Zwanzger, J G E Janzing, T Galesloot, L A Kiemeney, A Gajewska, E Glotzbach-Schoon, A Mühlberger, G Alpers, T Fydrich, L Fehm, A L Gerlach, T Kircher, T Lang, A Ströhle, V Arolt, H-U Wittchen, R Kalisch, C Büchel, A Hamm, M M Nöthen, M Romanos, K Domschke, P Pauli and A Reif

Mol Psychiatry advance online publication, February 7, 2017; doi:10.1038/mp.2017.2

Neural mechanisms of mismatch negativity dysfunction in schizophrenia

M Lee, P Sehatpour, M J Hoptman, P Lakatos, E C Dias, J T Kantrowitz, A M Martinez and D C Javitt

Mol Psychiatry advance online publication, February 7, 2017; doi:10.1038/mp.2017.3

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January 31 2017

Original Articles

Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms

H Engler, P Brendt, J Wischermann, A Wegner, R Röhling, T Schoemberg, U Meyer, R Gold, J Peters, S Benson and M Schedlowski

Mol Psychiatry advance online publication, January 31, 2017; doi:10.1038/mp.2016.264

Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior

Y R Yang, J H Jung, S-J Kim, K Hamada, A Suzuki, H J Kim, J H Lee, O-B Kwon, Y K Lee, J Kim, E-K Kim, H-J Jang, D-S Kang, J-S Choi, C J Lee, J Marshall, H-Y Koh, C-J Kim, H Seok, S H Kim, J H Choi, Y-B Choi, L Cocco, S H Ryu, J-H Kim and P-G Suh

Mol Psychiatry advance online publication, January 31, 2017; doi:10.1038/mp.2016.261

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January 24 2017

Original Articles

Hippocampal subfield volumes in mood disorders

B Cao, I C Passos, B Mwangi, H Amaral-Silva, J Tannous, M-J Wu, G B Zunta-Soares and J C Soares

Mol Psychiatry advance online publication, January 24, 2017; doi:10.1038/mp.2016.262

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder Open

M Ikeda, A Takahashi, Y Kamatani, Y Okahisa, H Kunugi, N Mori, T Sasaki, T Ohmori, Y Okamoto, H Kawasaki, S Shimodera, T Kato, H Yoneda, R Yoshimura, M Iyo, K Matsuda, M Akiyama, K Ashikawa, K Kashiwase, K Tokunaga, K Kondo, T Saito, A Shimasaki, K Kawase, T Kitajima, K Matsuo, M Itokawa, T Someya, T Inada, R Hashimoto, T Inoue, K Akiyama, H Tanii, H Arai, S Kanba, N Ozaki, I Kusumi, T Yoshikawa, M Kubo and N Iwata for the advanced Collaborative Study of Mood Disorder (COSMO) team

Mol Psychiatry advance online publication, January 24, 2017; doi:10.1038/mp.2016.259

ADNP/NAP dramatically increase microtubule end-binding protein–Tau interaction: a novel avenue for protection against tauopathy

Y Ivashko-Pachima, C Laura Sayas, A Malishkevich and I Gozes

Mol Psychiatry advance online publication, January 24, 2017; doi:10.1038/mp.2016.255

MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice

A C Mitchell, B Javidfar, V Pothula, D Ibi, E Y Shen, C J Peter, L K Bicks, T Fehr, Y Jiang, K J Brennand, R L Neve, J Gonzalez-Maeso and S Akbarian

Mol Psychiatry advance online publication, January 24, 2017; doi:10.1038/mp.2016.254

Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum

D R Roalf, R P R Nanga, P E Rupert, H Hariharan, M Quarmley, M E Calkins, E Dress, K Prabhakaran, M A Elliott, P J Moberg, R C Gur, R E Gur, R Reddy and B I Turetsky

Mol Psychiatry advance online publication, January 24, 2017; doi:10.1038/mp.2016.258

Cannabis use and risk of schizophrenia: a Mendelian randomization study Open

J Vaucher, B J Keating, A M Lasserre, W Gan, D M Lyall, J Ward, D J Smith, J P Pell, N Sattar, G Paré and M V Holmes

Mol Psychiatry advance online publication, January 24, 2017; doi:10.1038/mp.2016.252

Bipolar mood cycles and lunar tidal cycles Open

T A Wehr

Mol Psychiatry advance online publication, January 24, 2017; doi:10.1038/mp.2016.263

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January 17 2017

Original Articles

Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD Open

S A Maddox, V Kilaru, J Shin, T Jovanovic, L M Almli, B G Dias, S D Norrholm, N Fani, V Michopoulos, Z Ding, K N Conneely, E B Binder, K J Ressler and A K Smith

Mol Psychiatry advance online publication, January 17, 2017; doi:10.1038/mp.2016.250

Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia

T Notter, J M Coughlin, T Gschwind, U Weber-Stadlbauer, Y Wang, M Kassiou, A C Vernon, D Benke, M G Pomper, A Sawa and U Meyer

Mol Psychiatry advance online publication, January 17, 2017; doi:10.1038/mp.2016.248

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January 10 2017

Original Articles

The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders Open

H Chang, N Hoshina, C Zhang, Y Ma, H Cao, Y Wang, D-d Wu, S E Bergen, M Landén, C M Hultman, M Preisig, Z Kutalik, E Castelao, M Grigoroiu-Serbanescu, A J Forstner, J Strohmaier, J Hecker, T G Schulze, B Müller-Myhsok, A Reif, P B Mitchell, N G Martin, P R Schofield, S Cichon, M M Nöthen, The Swedish Bipolar Study Group, MooDS Bipolar Consortium, H Walter, S Erk, A Heinz, N Amin, C M van Duijn, A Meyer-Lindenberg, H Tost, X Xiao, T Yamamoto, M Rietschel and M Li

Mol Psychiatry advance online publication, January 10, 2017; doi:10.1038/mp.2016.231

Lipocalin-2 protects the brain during inflammatory conditions Open

S S Kang, Y Ren, C-C Liu, A Kurti, K E Baker, G Bu, Y Asmann and J D Fryer

Mol Psychiatry advance online publication, January 10, 2017; doi:10.1038/mp.2016.243

An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry

J L Meyers, J Zhang, J C Wang, J Su, S I Kuo, M Kapoor, L Wetherill, S Bertelsen, D Lai, J E Salvatore, C Kamarajan, D Chorlian, A Agrawal, L Almasy, L Bauer, K K Bucholz, G Chan, V Hesselbrock, L Koganti, J Kramer, S Kuperman, N Manz, A Pandey, M Seay, D Scott, R E Taylor, D M Dick, H J Edenberg, A Goate, T Foroud and B Porjesz

Mol Psychiatry advance online publication, January 10, 2017; doi:10.1038/mp.2016.239

A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia

X-Y Qin, H-T Wu, C Cao, Y P Loh and Y Cheng

Mol Psychiatry advance online publication, January 10, 2017; doi:10.1038/mp.2016.235

NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience Open

A Singh-Taylor, J Molet, S Jiang, A Korosi, J L Bolton, Y Noam, K Simeone, J Cope, Y Chen, A Mortazavi and T Z Baram

Mol Psychiatry advance online publication, January 10, 2017; doi:10.1038/mp.2016.240

OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency Open

M Ullrich, M Weber, A M Post, S Popp, J Grein, M Zechner, H Guerrero González, A Kreis, A G Schmitt, N Üçeyler, K-P Lesch and K Schuh

Mol Psychiatry advance online publication, January 10, 2017; doi:10.1038/mp.2016.232

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January 3 2017

Original Articles

In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens Open

R M Bastle, R J Oliver, A S Gardiner, N S Pentkowski, F Bolognani, A M Allan, T Chaudhury, M St. Peter, N Galles, C Smith, J L Neisewander and N I Perrone-Bizzozero

Mol Psychiatry advance online publication, January 3, 2017; doi:10.1038/mp.2016.238

The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder

N Dubey, J F Hoffman, K Schuebel, Q Yuan, P E Martinez, L K Nieman, D R Rubinow, P J Schmidt and D Goldman

Mol Psychiatry advance online publication, January 3, 2017; doi:10.1038/mp.2016.229

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

I Moreno-Gonzalez, G Edwards III, N Salvadores, M Shahnawaz, R Diaz-Espinoza and C Soto

Mol Psychiatry advance online publication, January 3, 2017; doi:10.1038/mp.2016.230

ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties Open

B St Pourcain, E B Robinson, V Anttila, B B Sullivan, J Maller, J Golding, D Skuse, S Ring, D M Evans, S Zammit, S E Fisher, B M Neale, R J L Anney, S Ripke, M V Hollegaard, T Werge, iPSYCH-SSI-Broad Autism Group, A Ronald, J Grove, D M Hougaard, A D Børglum, P B Mortensen, M J Daly and G Davey Smith

Mol Psychiatry advance online publication, January 3, 2017; doi:10.1038/mp.2016.198

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December 20 2016

Original Articles

Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder Open

G Roberts, A Perry, A Lord, A Frankland, V Leung, E Holmes-Preston, F Levy, R K Lenroot, P B Mitchell and M Breakspear

Mol Psychiatry advance online publication, December 20, 2016; doi:10.1038/mp.2016.216

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, D Bosch, D Asede, F Malhaire, F Acher, J Giraldo, E Valjent, I Ehrlich, F Ferraguti, J-P Pin, A Llebaria and C Goudet

Mol Psychiatry advance online publication, December 20, 2016; doi:10.1038/mp.2016.223

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December 13 2016

Letter to the Editor

Enrichment of factors regulating canonical Wnt signaling among autism risk genes

A Packer

Mol Psychiatry advance online publication, December 13, 2016; doi:10.1038/mp.2016.228

Original Articles

Altered brain processing of decision-making in healthy first-degree biological relatives of suicide completers

Y Ding, F Pereira, A Hoehne, M-M Beaulieu, M Lepage, G Turecki and F Jollant

Mol Psychiatry advance online publication, December 13, 2016; doi:10.1038/mp.2016.221

Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice

J D Gray, T G Rubin, J F Kogan, J Marrocco, J Weidmann, S Lindkvist, F S Lee, E F Schmidt and B S McEwen

Mol Psychiatry advance online publication, December 13, 2016; doi:10.1038/mp.2016.219

17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression

K Le Guennec, O Quenez, G Nicolas, D Wallon, S Rousseau, A-C Richard, J Alexander, P Paschou, C Charbonnier, C Bellenguez, B Grenier-Boley, D Lechner, M-T Bihoreau, R Olaso, A Boland, V Meyer, J-F Deleuze, P Amouyel, H M Munter, G Bourque, M Lathrop, T Frebourg, R Redon, L Letenneur, J-F Dartigues, O Martinaud, O Kalev, S Mehrabian, L Traykov, T Ströbel, I Le Ber, P Caroppo, S Epelbaum, T Jonveaux, F Pasquier, A Rollin-Sillaire, E Génin, L Guyant-Maréchal, G G Kovacs, J-C Lambert, D Hannequin, D Campion and A Rovelet-Lecrux and The CNR-MAJ collaborators

Mol Psychiatry advance online publication, December 13, 2016; doi:10.1038/mp.2016.226

Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder

A Y Lopez, X Wang, M Xu, A Maheshwari, D Curry, S Lam, A M Adesina, J L Noebels, Q-Q Sun and E C Cooper

Mol Psychiatry advance online publication, December 13, 2016; doi:10.1038/mp.2016.233

Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior

C M Mazzone, D Pati, M Michaelides, J DiBerto, J H Fox, G Tipton, C Anderson, K Duffy, J M McKlveen, J A Hardaway, S T Magness, W A Falls, S E Hammack, Z A McElligott, Y L Hurd and T L Kash

Mol Psychiatry advance online publication, December 13, 2016; doi:10.1038/mp.2016.218

Association of rare missense variants in the second intracellular loop of NaV1.7 sodium channels with familial autism Open

M Rubinstein, A Patowary, I B Stanaway, E McCord, R R Nesbitt, M Archer, T Scheuer, D Nickerson, W H Raskind, E M Wijsman, R Bernier, W A Catterall and Z Brkanac

Mol Psychiatry advance online publication, December 13, 2016; doi:10.1038/mp.2016.222

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December 6 2016

Original Articles

OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals Open

H Ehrenreich, M Mitjans, S Van der Auwera, T P Centeno, M Begemann, H J Grabe, S Bonn and K-A Nave

Mol Psychiatry advance online publication, December 6, 2016; doi:10.1038/mp.2016.208

Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons

N Shioda, Y Yabuki, Y Wang, M Uchigashima, T Hikida, T Sasaoka, H Mori, M Watanabe, M Sasahara and K Fukunaga

Mol Psychiatry advance online publication, December 6, 2016; doi:10.1038/mp.2016.200

Pattern of structural brain changes in social anxiety disorder after cognitive behavioral group therapy: a longitudinal multimodal MRI study

V R Steiger, A B Brühl, S Weidt, A Delsignore, M Rufer, L Jäncke, U Herwig and J Hänggi

Mol Psychiatry advance online publication, December 6, 2016; doi:10.1038/mp.2016.217

Erratum

Peripheral administration of lactate produces antidepressant-like effects Open

A Carrard, M Elsayed, M Margineanu, B Boury-Jamot, L Fragnière, E M Meylan, J-M Petit, H Fiumelli, P J Magistretti and J-L Martin

Mol Psychiatry advance online publication, December 6, 2016; doi:10.1038/mp.2016.237

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November 29 2016

Original Articles

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment

M M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, A Renblom, S C Sim, E M Peñas-Lledó, P Courtet, A Llerena, B T Baune, D J de Quervain, A Papassotiropoulos, R F Tyndale, E B Binder, U Dannlowski and M Ingelman-Sundberg

Mol Psychiatry advance online publication, November 29, 2016; doi:10.1038/mp.2016.204

Gestational vitamin D deficiency and autism-related traits: the Generation R Study Open

A A E Vinkhuyzen, D W Eyles, T H J Burne, L M E Blanken, C J Kruithof, F Verhulst, V W Jaddoe, H Tiemeier and J J McGrath

Mol Psychiatry advance online publication, November 29, 2016; doi:10.1038/mp.2016.213

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November 15 2016

Letter to the Editor

The NF-κB signaling pathway: an important therapeutic target in psychiatric disorders

M A Altinoz, B Ince, C Tek, V H Srihari and S Guloksuz

Mol Psychiatry advance online publication, November 15, 2016; doi:10.1038/mp.2016.207

Original Articles

Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism

L M Hernandez, K Krasileva, S A Green, L E Sherman, C Ponting, R McCarron, J K Lowe, D H Geschwind, S Y Bookheimer and M Dapretto

Mol Psychiatry advance online publication, November 15, 2016; doi:10.1038/mp.2016.209

A DNA methylation biomarker of alcohol consumption Open

C Liu, R E Marioni, Å K Hedman, L Pfeiffer, P-C Tsai, L M Reynolds, A C Just, Q Duan, C G Boer, T Tanaka, C E Elks, S Aslibekyan, J A Brody, B Kühnel, C Herder, L M Almli, D Zhi, Y Wang, T Huan, C Yao, M M Mendelson, R Joehanes, L Liang, S-A Love, W Guan, S Shah, A F McRae, A Kretschmer, H Prokisch, K Strauch, A Peters, P M Visscher, N R Wray, X Guo, K L Wiggins, A K Smith, E B Binder, K J Ressler, M R Irvin, D M Absher, D Hernandez, L Ferrucci, S Bandinelli, K Lohman, J Ding, L Trevisi, S Gustafsson, J H Sandling, L Stolk, A G Uitterlinden, I Yet, J E Castillo-Fernandez, T D Spector, J D Schwartz, P Vokonas, L Lind, Y Li, M Fornage, D K Arnett, N J Wareham, N Sotoodehnia, K K Ong, J B J van Meurs, K N Conneely, A A Baccarelli, I J Deary, J T Bell, K E North, Y Liu, M Waldenberger, S J London, E Ingelsson and D Levy

Mol Psychiatry advance online publication, November 15, 2016; doi:10.1038/mp.2016.192

JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche Open

H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson, H van Praag and E T Coffey

Mol Psychiatry advance online publication, November 15, 2016; doi:10.1038/mp.2016.203

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November 8 2016

Letters to the Editor

Challenges in conducting genetic analyses based on data-driven classification of major depressive disorder

V-P Mäkinen

Mol Psychiatry advance online publication, November 8, 2016; doi:10.1038/mp.2016.205

Problems with latent class analysis to detect data-driven subtypes of depression

H M van Loo, R B K Wanders, K J Wardenaar and E I Fried

Mol Psychiatry advance online publication, November 8, 2016; doi:10.1038/mp.2016.202

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November 1 2016

Original Article

Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor Open

E Scarr, M Udawela, E A Thomas and B Dean

Mol Psychiatry advance online publication, November 1, 2016; doi:10.1038/mp.2016.195

Corrigendum

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression Open

E Bouvier, F Brouillard, J Molet, D Claverie, J-H Cabungcal, N Cresto, N Doligez, C Rivat, K Q Do, C Bernard, J-J Benoliel and C Becker

Mol Psychiatry advance online publication, November 1, 2016; doi:10.1038/mp.2016.211

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October 25 2016

Original Articles

Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells Open

W Li, L Huang, J Zeng, W Lin, K Li, J Sun, W Huang, J Chen, G Wang, Q Ke, J Duan, X Lai, R Chen, M Liu, Y Liu, T Wang, X Yang, Y Chen, H Xia and A P Xiang

Mol Psychiatry advance online publication, October 25, 2016; doi:10.1038/mp.2016.191

AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior

A Mateus-Pinheiro, N D Alves, P Patrício, A R Machado-Santos, E Loureiro-Campos, J M Silva, V M Sardinha, J Reis, H Schorle, J F Oliveira, J Ninkovic, N Sousa and L Pinto

Mol Psychiatry advance online publication, October 25, 2016; doi:10.1038/mp.2016.169

Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer’s disease therapy

S Moriguchi, T Ishizuka, Y Yabuki, N Shioda, Y Sasaki, H Tagashira, H Yawo, J Z Yeh, H Sakagami, T Narahashi and K Fukunaga

Mol Psychiatry advance online publication, October 25, 2016; doi:10.1038/mp.2016.187

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October 18 2016

Original Articles

Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer’s disease-related signaling

D A Bangasser, H Dong, J Carroll, Z Plona, H Ding, L Rodriguez, C McKennan, J G Csernansky, S H Seeholzer and R J Valentino

Mol Psychiatry advance online publication, October 18, 2016; doi:10.1038/mp.2016.185

Peripheral administration of lactate produces antidepressant-like effects Open

A Carrard, M Elsayed, M Margineanu, B Boury-Jamot, L Fragnière, E M Meylan, J-M Petit, H Fiumelli, P J Magistretti and J-L Martin

Mol Psychiatry advance online publication, October 18, 2016; doi:10.1038/mp.2016.179

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial Open

R E Frye, J Slattery, L Delhey, B Furgerson, T Strickland, M Tippett, A Sailey, R Wynne, S Rose, S Melnyk, S Jill James, J M Sequeira and E V Quadros

Mol Psychiatry advance online publication, October 18, 2016; doi:10.1038/mp.2016.168

Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions Open

N Kappelmann, G Lewis, R Dantzer, P B Jones and G M Khandaker

Mol Psychiatry advance online publication, October 18, 2016; doi:10.1038/mp.2016.167

DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

P-M Martin, R E Stanley, A P Ross, A E Freitas, C E Moyer, A C Brumback, J Iafrati, K S Stapornwongkul, S Dominguez, S Kivimäe, K A Mulligan, M Pirooznia, W R McCombie, J B Potash, P P Zandi, S M Purcell, S J Sanders, Y Zuo, V S Sohal and B N R Cheyette

Mol Psychiatry advance online publication, October 18, 2016; doi:10.1038/mp.2016.184

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models Open

J Xu, B J Hartley, P Kurup, A Phillips, A Topol, M Xu, C Ononenyi, E Foscue, S-M Ho, T D Baguley, N Carty, C S Barros, U Müller, S Gupta, P Gochman, J Rapoport, J A Ellman, C Pittenger, B Aronow, A C Nairn, M W Nestor, P J Lombroso and K J Brennand

Mol Psychiatry advance online publication, October 18, 2016; doi:10.1038/mp.2016.163

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October 11 2016

News and Commentary

High-resolution diffusion imaging: ready to become more than just a research tool in psychiatry?

S M Grieve and J J Maller

Mol Psychiatry advance online publication, October 11, 2016; doi:10.1038/mp.2016.170

Original Article

Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held

B Zhang, E Seigneur, P Wei, O Gokce, J Morgan and T C Südhof

Mol Psychiatry advance online publication, October 11, 2016; doi:10.1038/mp.2016.157

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October 4 2016

Letter to the Editor

Acute stress is not acute: sustained enhancement of glutamate release after acute stress involves readily releasable pool size and synapsin I activation

L Musazzi, P Tornese, N Sala and M Popoli

Mol Psychiatry advance online publication, October 4, 2016; doi:10.1038/mp.2016.175

Original Article

Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat

M D Lange, T Daldrup, F Remmers, H J Szkudlarek, J Lesting, S Guggenhuber, S Ruehle, K Jüngling, T Seidenbecher, B Lutz and H C Pape

Mol Psychiatry advance online publication, October 4, 2016; doi:10.1038/mp.2016.156

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September 27 2016

Original Article

A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses Open

X Yang, C Yao, T Tian, X Li, H Yan, J Wu, H Li, L Pei, D Liu, Q Tian, L-Q Zhu and Y Lu

Mol Psychiatry advance online publication, September 27, 2016; doi:10.1038/mp.2016.151

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September 20 2016

Original Articles

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression Open

E Bouvier, F Brouillard, J Molet, D Claverie, J-H Cabungcal, N Cresto, N Doligez, C Rivat, K Q Do, C Bernard, J-J Benoliel and C Becker

Mol Psychiatry advance online publication, September 20, 2016; doi:10.1038/mp.2016.144

The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model Open

M Cissé, E Duplan, T Lorivel, J Dunys, C Bauer, X Meckler, Y Gerakis, I Lauritzen and F Checler

Mol Psychiatry advance online publication, September 20, 2016; doi:10.1038/mp.2016.152

Prevention of behavioral deficits in rats exposed to folate receptor antibodies: implication in autism

A Desai, J M Sequeira and E V Quadros

Mol Psychiatry advance online publication, September 20, 2016; doi:10.1038/mp.2016.153

PDE11A negatively regulates lithium responsivity Open

G Pathak, M J Agostino, K Bishara, W R Capell, J L Fisher, S Hegde, B A Ibrahim, K Pilarzyk, C Sabin, T Tuczkewycz, S Wilson and M P Kelly

Mol Psychiatry advance online publication, September 20, 2016; doi:10.1038/mp.2016.155

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August 30 2016

Original Article

Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2 Open

E Barbier, A L Johnstone, B B Khomtchouk, J D Tapocik, C Pitcairn, F Rehman, E Augier, A Borich, J R Schank, C A Rienas, D J Van Booven, H Sun, D Nätt, C Wahlestedt and M Heilig

Mol Psychiatry advance online publication, August 30, 2016; doi:10.1038/mp.2016.131

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August 23 2016

Letter to the Editor

Dysregulation of the glutamatergic receptors after antidepressant treatment in human neural progenitor cells

C Cruceanu, J P Lopez, W-T Tsai and G Turecki

Mol Psychiatry advance online publication, August 23, 2016; doi:10.1038/mp.2016.138

Original Articles

CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery Open

M J A G Henckens, Y Printz, U Shamgar, J Dine, M Lebow, Y Drori, C Kuehne, A Kolarz, M Eder, J M Deussing, N J Justice, O Yizhar and A Chen

Mol Psychiatry advance online publication, August 23, 2016; doi:10.1038/mp.2016.133

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females Open

E E Palmer, T Stuhlmann, S Weinert, E Haan, H Van Esch, M Holvoet, J Boyle, M Leffler, M Raynaud, C Moraine, H van Bokhoven, T Kleefstra, K Kahrizi, H Najmabadi, H-H Ropers, M R Delgado, D Sirsi, S Golla, A Sommer, M P Pietryga, W K Chung, J Wynn, L Rohena, E Bernardo, D Hamlin, B M Faux, D K Grange, L Manwaring, J Tolmie, S Joss, DDD Study, J M Cobben, F A M Duijkers, J M Goehringer, T D Challman, F Hennig, U Fischer, A Grimme, V Suckow, L Musante, J Nicholl, M Shaw, S P Lodh, Z Niu, J A Rosenfeld, P Stankiewicz, T J Jentsch, J Gecz, M Field and V M Kalscheuer

Mol Psychiatry advance online publication, August 23, 2016; doi:10.1038/mp.2016.135

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August 9 2016

Original Articles

All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class Open

E Castillo-Gómez, B Oliveira, D Tapken, S Bertrand, C Klein-Schmidt, H Pan, P Zafeiriou, J Steiner, B Jurek, R Trippe, H Prüss, W-H Zimmermann, D Bertrand, H Ehrenreich and M Hollmann

Mol Psychiatry advance online publication, August 9, 2016; doi:10.1038/mp.2016.125

mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions Open

L E Jin, M Wang, S-T Yang, Y Yang, V C Galvin, T C Lightbourne, D Ottenheimer, Q Zhong, J Stein, A Raja, C D Paspalas and A F T Arnsten

Mol Psychiatry advance online publication, August 9, 2016; doi:10.1038/mp.2016.129

Corrigendum

Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia Open

S E Legge, M L Hamshere, S Ripke, A F Pardinas, J I Goldstein, E Rees, A L Richards, G Leonenko, L F Jorskog, Clozapine-Induced Agranulocytosis Consortium, K D Chambert, D A Collier, G Genovese, I Giegling, P Holmans, A Jonasdottir, G Kirov, S A McCarroll, J H MacCabe, K Mantripragada, J L Moran, B M Neale, H Stefansson, D Rujescu, M J Daly, P F Sullivan, M J Owen, M C O'Donovan and J T R Walters

Mol Psychiatry advance online publication, August 9, 2016; doi:10.1038/mp.2016.137

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August 2 2016

Original Article

Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model

J J Donegan, J A Tyson, S Y Branch, M J Beckstead, S A Anderson and D J Lodge

Mol Psychiatry advance online publication, August 2, 2016; doi:10.1038/mp.2016.121

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July 26 2016

Original Articles

Exome sequencing of Pakistani consanguineous families identifies 30 novel candidate genes for recessive intellectual disability Open

S Riazuddin, M Hussain, A Razzaq, Z Iqbal, M Shahzad, D L Polla, Y Song, E van Beusekom, A A Khan, L Tomas-Roca, M Rashid, M Y Zahoor, W M Wissink-Lindhout, M A R Basra, M Ansar, Z Agha, K van Heeswijk, F Rasheed, M Van de Vorst, J A Veltman, C Gilissen, J Akram, T Kleefstra, M Z Assir, UK10K, D Grozeva, K Carss, F L Raymond, T D O'Connor, S A Riazuddin, S N Khan, Z M Ahmed, A P M de Brouwer, H van Bokhoven and S Riazuddin

Mol Psychiatry advance online publication, July 26, 2016; doi:10.1038/mp.2016.109

Cellular and molecular basis for stress-induced depression Open

J-S Seo, J Wei, L Qin, Y Kim, Z Yan and P Greengard

Mol Psychiatry advance online publication, July 26, 2016; doi:10.1038/mp.2016.118

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July 19 2016

Original Article

Suicide in obsessive–compulsive disorder: a population-based study of 36788 Swedish patients Open

L Fernández de la Cruz, M Rydell, B Runeson, B M D'Onofrio, G Brander, C Rück, P Lichtenstein, H Larsson and D Mataix-Cols

Mol Psychiatry advance online publication, July 19, 2016; doi:10.1038/mp.2016.115

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July 12 2016

Original Articles

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects Open

H-J Kim, M-H Cho, W H Shim, J K Kim, E-Y Jeon, D-H Kim and S-Y Yoon

Mol Psychiatry advance online publication, July 12, 2016; doi:10.1038/mp.2016.103

Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia Open

S E Legge, M L Hamshere, S Ripke, A F Pardinas, J I Goldstein, E Rees, A L Richards, G Leonenko, L F Jorskog, Clozapine-Induced Agranulocytosis Consortium, K D Chambert, D A Collier, G Genovese, I Giegling, P Holmans, A Jonasdottir, G Kirov, S A McCarroll, J H MacCabe, K Mantripragada, J L Moran, B M Neale, H Stefansson, D Rujescu, M J Daly, P F Sullivan, M J Owen, M C O'Donovan and J T R Walters

Mol Psychiatry advance online publication, July 12, 2016; doi:10.1038/mp.2016.97

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May 31 2016

Original Article

Effects of ANK3 variation on gray and white matter in bipolar disorder

E T C Lippard, K P Jensen, F Wang, J A Y Johnston, L Spencer, B Pittman, J Gelernter and H P Blumberg

Mol Psychiatry advance online publication, May 31, 2016; doi:10.1038/mp.2016.76

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May 24 2016

Original Article

Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis Open

T Wise, J Radua, E Via, N Cardoner, O Abe, T M Adams, F Amico, Y Cheng, J H Cole, C de Azevedo Marques Périco, D P Dickstein, T F D Farrow, T Frodl, G Wagner, I H Gotlib, O Gruber, B J Ham, D E Job, M J Kempton, M J Kim, P C M P Koolschijn, G S Malhi, D Mataix-Cols, A M McIntosh, A C Nugent, J T O'Brien, S Pezzoli, M L Phillips, P S Sachdev, G Salvadore, S Selvaraj, A C Stanfield, A J Thomas, M J van Tol, N J A van der Wee, D J Veltman, A H Young, C H Fu, A J Cleare and D Arnone

Mol Psychiatry advance online publication, May 24, 2016; doi:10.1038/mp.2016.72

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May 17 2016

Original Article

Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium Open

P Devaraju, J Yu, D Eddins, M M Mellado-Lagarde, L R Earls, J J Westmoreland, G Quarato, D R Green and S S Zakharenko

Mol Psychiatry advance online publication, May 17, 2016; doi:10.1038/mp.2016.75

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April 19 2016

Original Article

Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model Open

R E Monyak, D Emerson, B P Schoenfeld, X Zheng, D B Chambers, C Rosenfelt, S Langer, P Hinchey, C H Choi, T V McDonald, F V Bolduc, A Sehgal, S M J McBride and T A Jongens

Mol Psychiatry advance online publication, April 19, 2016; doi:10.1038/mp.2016.51

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April 5 2016

Original Article

Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence Open

J L Cadet, C Brannock, I N Krasnova, S Jayanthi, B Ladenheim, M T McCoy, D Walther, A Godino, M Pirooznia and R S Lee

Mol Psychiatry advance online publication, April 5, 2016; doi:10.1038/mp.2016.48

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March 29 2016

Original Article

Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers Open

E Shokri-Kojori, D Tomasi, C E Wiers, G-J Wang and N D Volkow

Mol Psychiatry advance online publication, March 29, 2016; doi:10.1038/mp.2016.25

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