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Reelin glycoprotein: structure, biology and roles in health and disease

Molecular Psychiatry volume 10, pages 251–257 (2005)Cite this article

Abstract

Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.

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Acknowledgements

The work of author has been supported by Stanley Medical Research Institute, March of Dimes, The Jonty Foundation and the Kunin Fund of St Paul Foundation. I am grateful for secretarial assistance by Ms Laurie Iversen and Danielle Johansson.

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  1. Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN, USA

    S H Fatemi

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Fatemi, S. Reelin glycoprotein: structure, biology and roles in health and disease. Mol Psychiatry 10, 251–257 (2005). https://doi.org/10.1038/sj.mp.4001613

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