Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
We present a comprehensive, up-to-date review of host-directed therapeutics (HDTs) to improve clinical outcome in tuberculosis (TB) disease, summarizing all compounds, primarily repurposed drugs, tested in human clinical trials. Where available, results from each phase of these investigations are discussed.