Abstract
Outcomes after unmanipulated haploidentical stem cell transplantation (Haplo) and after unrelated cord blood transplantation (UCBT) are encouraging and have become alternative options to treat patients with high-risk acute leukemia without human leukocyte antigen (HLA) matched donor. We compared outcomes after UCBT and Haplo in adults with de novo acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Median follow-up was 24 months. Analysis was performed separately for patients with AML, n=918 (Haplo=360, UCBT=558) and ALL, n=528 (Haplo=158 and UCBT=370). UCBT was associated with delayed engraftment and higher graft failure in both AML and ALL recipients. In multivariate analysis, UCBT was associated with lower incidence of chronic graft-vs-host disease both in the AML group (hazard ratio (HR)=0.63, P=0.008) and in the ALL group (HR=0.58, P=0.01). Not statistically significant differences were observed between Haplo and UCBT for relapse incidence (HR=0.95, P=0.76 for AML and HR=0.82, P=0.31 for ALL), non-relapse mortality (HR=1.16, P=0.47 for AML and HR=1.23, P=0.23 for ALL) and leukemia-free survival (HR 0.78, P=0.78 for AML and HR=1.00, P=0.84 for ALL). There were no statistically differences on main outcomes after unmanipulated Haplo and UCBT, and both approaches are valid for acute leukemia patients lacking a HLA matched donor. Both strategies expand the donor pool for patients in need.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453–474.
Rowe JM . Prognostic factors in adult acute lymphoblastic leukaemia. Br J Haematol 2010; 150: 389–405.
Patriarca F, Luznik L, Medeot M, Zecca M, Bacigalupo A, Di Bartolomeo P et al. Experts' considerations on HLA-haploidentical stem cell transplantation. Eur J Haematol 2014; 93: 187–197.
Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004; 351: 2276–2285.
Eapen M, Rocha V, Sanz G, Scaradavou A, Zhang MJ, Arcese W et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol 2010; 11: 653–660.
Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang MJ, Champlin RE et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004; 351: 2265–2275.
Ballen KK, Spitzer TR . The great debate: haploidentical or cord blood transplant. Bone Marrow Transplant 2011; 46: 323–329.
Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, McGlave PB, Miller JS et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105: 1343–1347.
Scaradavou A, Brunstein CG, Eapen M, Le-Rademacher J, Barker JN, Chao N et al. Double unit grafts successfully extend the application of umbilical cord blood transplantation in adults with acute leukemia. Blood 2013; 121: 752–758.
Brunstein CG, Barker JN, Weisdorf DJ, DeFor TE, Miller JS, Blazar BR et al. Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood 2007; 110: 3064–3070.
Ruggeri A, Sanz G, Bittencourt H, Sanz J, Rambaldi A, Volt F et al. Comparison of outcomes after single or double cord blood transplantation in adults with acute leukemia using different types of myeloablative conditioning regimen, a retrospective study on behalf of Eurocord and the Acute Leukemia Working Party of EBMT. Leukemia 2014; 28: 779–786.
Eapen M, Rocha V, Sanz G, Scaradavou A, Zhang MJ, Arcese W et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol 2010; 11: 653–660.
Brunstein CG, Eapen M, Ahn KW, Appelbaum FR, Ballen KK, Champlin RE et al. Reduced-intensity conditioning transplantation in acute leukemia: the effect of source of unrelated donor stem cells on outcomes. Blood 2012; 119: 5591–5598.
Aversa F, Tabilio A, Terenzi A, Velardi A, Falzetti F, Giannoni C et al. Successful engraftment of T-cell-depleted haploidentical ‘three-loci’ incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood 1994; 84: 3948–3955.
Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 1998; 339: 1186–1193.
Champlin R, Hesdorffer C, Lowenberg B, Martelli MF, Mertelsmann RH, Reisner Y et al. Haploidentical 'megadose' stem cell transplantation in acute leukemia: recommendations for a protocol agreed upon at the Perugia and Chicago meetings. Leukemia 2002; 16: 427–428.
Bashey A, Zhang X, Sizemore CA, Manion K, Brown S, Holland HK et al. T-cell-replete HLA-haploidentical hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantation. J Clin Oncol 2013; 31: 1310–1316.
Szydlo R, Goldman JM, Klein JP, Gale RP, Ash RC, Bach FH et al. Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings. J Clin Oncol 1997; 15: 1767–1777.
Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974; 18: 295–304.
Terwey TH, Vega-Ruiz A, Hemmati PG, Martus P, Dietz E, le Coutre P et al. NIH-defined graft-versus-host disease after reduced intensity or myeloablative conditioning in patients with acute myeloid leukemia. Leukemia 2012; 26: 536–542.
Kaplan. Non parametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457–481.
Cox. Regression models and life tables. J R Stat Soc 1972; 34: 187.
Fine JP, Gray RJ . A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999; 94: 496–509.
Brunstein CG, Fuchs EJ, Carter SL, Karanes C, Costa LJ, Wu J et al. Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood 2011; 118: 282–288.
Labopin M, Ruggeri A, Gorin NC, Gluckman E, Blaise D, Mannone L et al. Cost-effectiveness and clinical outcomes of double versus single cord blood transplantation in adults with acute leukemia in France. Haematologica 2014; 99: 535–540.
Eapen M, Klein JP, Ruggeri A, Spellman S, Lee SJ, Anasetti C et al. Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy. Blood 2014; 123: 133–140.
Gutman JA, Riddell SR, McGoldrick S, Delaney C . Double unit cord blood transplantation: who wins-and why do we care? Chimerism 2010; 1: 21–22.
de Lima M, McNiece I, Robinson SN, Munsell M, Eapen M, Horowitz M et al. Cord-blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med 2012; 367: 2305–2315.
Farag SS, Srivastava S, Messina-Graham S, Schwartz J, Robertson MJ, Abonour R et al. In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies. Stem Cells Dev 2013; 22: 1007–1015.
Ji SQ, Chen HR, Wang HX, Yan HM, Zhu L, Liu J et al. G-CSF-primed haploidentical marrow transplantation without ex vivo T cell depletion: an excellent alternative for high-risk leukemia. Bone Marrow Transplant 2002; 30: 861–866.
Lu DP, Dong L, Wu T, Huang XJ, Zhang MJ, Han W et al. Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation. Blood 2006; 107: 3065–3073.
Luznik L, Bolanos-Meade J, Zahurak M, Chen AR, Smith BD, Brodsky R et al. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood 2010; 115: 3224–3230.
Raiola AM, Dominietto A, Ghiso A, Di Grazia C, Lamparelli T, Gualandi F et al. Unmanipulated haploidentical bone marrow transplantation and posttransplantation cyclophosphamide for hematologic malignancies after myeloablative conditioning. Biol Blood Marrow Transplant 2013; 19: 117–122.
Di Bartolomeo P, Santarone S, De Angelis G, Picardi A, Cudillo L, Cerretti R et al. Haploidentical, unmanipulated, G-CSF-primed bone marrow transplantation for patients with high-risk hematologic malignancies. Blood 2013; 121: 849–857.
Peccatori J, Forcina A, Clerici D, Crocchiolo R, Vago L, Stanghellini MT et al. Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors. Leukemia 2014; 29: 396–405.
Anasetti C, Logan BR, Lee SJ, Waller EK, Weisdorf DJ, Wingard JR et al. Peripheral-blood stem cells versus bone marrow from unrelated donors. N Engl J Med 2012; 367: 1487–1496.
Schmitz N, Beksac M, Bacigalupo A, Ruutu T, Nagler A, Gluckman E et al. Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia: 3-year results from the EBMT randomized trial. Haematologica 2005; 90: 643–648.
Labopin M, Gorin NC, Polge E, Socie G, Gurman G, Gluckman E et al. A prospective registration study to determine feasibility of hematopoietic SCT in adults with acute leukemia: planning, expectations and reality. Bone Marrow Transplant 2014; 49: 376–381.
Klingebiel T, Cornish J, Labopin M, Locatelli F, Darbyshire P, Handgretinger R et al. Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group. Blood 2010; 115: 3437–3446.
Ciceri F, Labopin M, Aversa F, Rowe JM, Bunjes D, Lewalle P et al. A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation. Blood 2008; 112: 3574–3581.
Acknowledgements
The authors thank Chantal Kenzey for helping with data collection and the association ‘Cordons de vie’, Monaco. VR is funded of National Institute Health Research (NIHR)-Biomedical Research Centre (BRC) funding scheme. Professor Noel Milpied, CHU Bordeaux, Pessac, France; Professor JJ Cornelissen, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands; Professor Ihsan Karadogan, Stem Cell Transplant Unit, Medical Park Hospitals, Antalya, Turkey; Professor Patrice Chevallier, Department of D'Hematologie, CHU Nantes, Nantes, France; Professor Mohamad Mohty, Hopital Saint Antoine, Paris, France; Professor E Deconinck, Service d'Hématologie, Hopital Jean Minjoz, Besancon, France; Professor Boris Afanasyev, SPb State I. Pavlov Medical University, St Petersburg, Russia; Professor Johanna Tischer, Klinikum Grosshadern, Munich, Germany; Professor Gérard Socié, Department of Hematology-BMT, Hopital St Louis, Paris, France; Professor P-S Rohrlich, Hôpital de l'ARCHET I, Nice, France; Professor Alessandro Rambaldi, Azienda Ospedaliera Papa Giovanni XXIII-Hematology and Bone Marrow Transplant Unit, Bergamo, Italy; Professor G Bandini, Bologna University, S Orsola-Malpighi Hospital, Bologna, Italy; Professor B Kremens, Department of Bone Marrow Transplantation, University Hospital, Essen, Germany; Professor Z Gülbas, Bone Marrow Transplantation Department, Anadolu Medical Center Hospital, Kocaeli, Turkey; Professor GF Mufti, Department of Haematological Medicine, GKT School of Medicine, London, UK; Professor Menachem Bitan, Tel-Aviv University, Tel-Hashomer, Israel; Professor I Yakoub-Agha, Hôpital Huriez, UAM allo-CSH, CHRU, Lille, France; Professor C Tarella, Azienda Ospedaliera S Giovanni, Torino, Italy; Professor E Petersen, University Medical Centre, Utrecht, The Netherlands; Professor H Greinix, Medical University Graz, Graz, Austria; Professor J-M Ribera Santasusana, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain; Professor G Gunhan, Adult Stem Cell Transplantation Unit, Department of Hematology, Ankara University Faculty of Medicine, Ankara, Turkey; Professor N Fegueux, Département d'Hématologie Clinique, CHU Lapeyronie, Montpellier, France; Professor Depei Wu, Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Professor A Ghavamzadeh, Hematology-Oncology and BMT Research, Shariati Hospital, Teheran, Iran; Professor J-Y Cahn, Hopital A Michallon, Hématologie Clinique, Pole Cancérologie, Grenoble, France; Professor C Cordonnier, Hôpital Henri Mondor, Creteil, France; Professor J-O Bay, Fédération de Greffe de Moelle et de, Clermont-Ferrand, France; Professor I Majolino, Ospedale S Camillo-Forlanini, Rome, Italy; Professor G Irrera, Azienda Ospedaliera, Reggio Calabria, Italy; Professor M Potter, Royal Marsden Hospital, London, UK; Hôpital Nord, Saint Etienne Cedex 2, France; Professor F Guilhot, Hopital La Miletrie, Poitiers, France; Professor Paul Cannell, RP Group Royal Perth Hospital, Perth, Australia; Professor I Heras, Hospital Morales Meseguer, Murcia, Spain; Professor A Olivieri, Azienda Ospedali Riuniti di Ancona, Ancona-Torrete, Italy; Professor G Ehninger, Universitaetsklinikum Dresden, Dresden, Germany; Professor J Passweg, University Hospital, Basel, Switzerland; Professor O Reman, Centre Hospitalier Universitaire, Caen, France; Professor J Cornish, Bristol Royal Hospital for Children, Bristol, UK; Professor C Craddock, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK; Professor M-J Pascual Cascon, Hospital Carlos Haya, Málaga, Spain; Professor R Fanin, University Hospital, Udine, Italy; Professor H Einsele, Allogeneic Stem Cell Transplant Center, Würzburg, Germany; Professor K Thomson, University College London Hospital, London, UK; Professor P Gomez Garcia, Hospital Reina Sofia, Córdoba, Spain; Professor BE Gibson, Glasgow Royal Infirmary, Glasgow, UK; Professor C Solano, Hospital Clínico Universitario, Valencia, Spain; Professor M Jurado Chacon, Hospital University Virgen de las Nieves, Granada, Spain; Professor L Clement, Unit de Transplantation Médullaire, Vandoeuvre Les Nancy, France; Professor NH Russell, Nottingham City Hospital, Nottingham, UK; Professor J-L Diez-Martin, Hospital Gregorio Marañón, Madrid, Spain; Professor Mair Pedro de Souza, Hospital Amaral Carvalho, Jau, Brazil; Professor D Bunjes, Medizinische Klinik und Poliklinik, Ulm, Germany; Professor Montserrat Rovira, Hospital Clinic, Barcelona, Spain; Professor Reuven Or, Hadassah University Hospital, Jerusalem, Israel; Professor S Nguyen, Hopital Pitie-Salpetriere, Paris, France; Professor P Pioltelli, Ospedale San Gerardo, Monza, Italy; Professor M Grasso, Az Ospedaliera S Croce e Carle, Cuneo, Italy; Professor N Ifrah, CHRU, Service des Maladies du Sang, Angers, France; Professor G Guillerm, CHU Morvan, Brest, France; Professor T Lamy, Centre Hospitalier Universitaire de Rennes, Rennes, France; Professor W Rösler, University Hospital Erlangen, Erlangen, Germany; Professor F Jardin, Centre Henri Becquerel, Rouen, France; Professor U Schanz, University Hospital, Zürich, Switzerland; Professor J Maertens, University Hospital Gasthuisberg, Leuven, Belgium; Professor Y Bertrand, Hôpital E Herriot, Lyon, France; Professor O Ringden, Department of Hematology, Karolinska University Hospital, Huddinge, Sweden; Professor M Zecca, Policlinico San Matteo, Pavia, Italy; Professor G Martinelli, European Institute of Oncology, Milano, Italy; Professor R Scime, Ospedale V Cervello, Palermo, Italy; Professor M Yeshurun, Beilinson Hospital, Petach-Tikva, Israel; Professor J-S Kühl, Charité, Campus Benjamin Franklin, Berlin, Germany; Professor X Poiré, University Hospital VUB, Brussels, Belgium; Professor T de Revel, Hôpital Percy, Clamart, France; Professor JH Veelken, Leiden University Hospital, Leiden, The Netherlands; Professor Jane Apperley, Imperial College, London, UK; Professor P Kalhs, Medizinische Universitaet Wien, Vienna, Austria; Professor T Zuckerman, Department of Hematology, Rambam Health Care Campus, Haifa, Israel; Professor L Castagna, Istituto Clinico Humanitas, Milano, Italy; Professor M Aljurf, Oncology (Section of Adult Haematolgy/BMT), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; Professor A Anagnostopoulos, Haematology Department/BMT Unit, George Papanicolaou General Hospital, Thessaloniki, Greece; Professor E Tholouli, Manchester Royal Infirmary, Manchester, UK; Professor N Kröger, Department of Stem cell Transplantation, University Hospital Eppendorf, Hamburg, Germany; Professor Bourhis, BMT Service, Division of Hematology, Department of Medical Oncology, Gustave Roussy, Institut de Cancérologie, Villejuif, France; Professor Y Beguin, University of Liege, Liege, Belgium; Professor D Caballero, Hospital Clínico, Salamanca, Spain; Professor C Favre, Unità Operativa Oncoematologia Pediatrica, Pisa, Italy; Professor C Schmid, Klinikum Augsburg, II Medizinische Klinik, Augsburg, Germany; Professor L Cavanna, Hospital Guglielmo da Saliceto, Piacenza, Italy; Professor A Peniket, Department of Haematology, Oxford, UK; Professor Y Chalandon, Hopitaux Universitaires de Geneve, Geneva, Switzerland; Professor R Cairoli, Ospedale di Niguarda Ca' Granda, Milano, Italy; Professor G Saglio, University of Torino, Torino, Italy; Professor S Sica, Universita Cattolica S Cuore, Rome, Italy; Professor P Dreger, University of Heidelberg, Medizinische Klinik u Poliklinik V, Heidelberg, Germany; Professor C Peschel, Klinkum Rechts der Isar, Munich, Germany; Professor J Sanchez de Toledo, Hospital Vall d'Hebron, Barcelona, Spain; Professor J Clausen, Elisabethinen-Hospital, Linz, Austria; Professor A Huynh, CHU de Toulouse Department of Hematologie, Hopital Purpan, Toulouse, France; Professor K Schäfer-Eckart, Klinikum Nürnberg, Nürnberg, Germany; Professor D Deeren, Hematology and Oncology Department; Heilig Hartziekenhuis, Roeselare, Belgium; Professor G Specchia, Universita degli Studi di Bari, Bari, Italy; Professor B Lioure, CHU Hautepierre, Service d'Onco Hematologie, Strasbourg, France; Professor A Wahlin, Umea University Hospital, Umeå, Sweden; Professor LA Noens, University Hospital Gent, Gent, Belgium; Professor I Espigado, Hospital 'Virgen del Rocio', Sevilla, Spain; Professor E Holler, University Regensburg, Regensburg, Germany; Professor E Angelucci, Ospedale A Businco, Cagliari, Italy; PO 'R Binaghi', Cagliari, Italy; Professor D Bordessoule, CHRU Limoges, Limoges, France; Professor P Galieni, Mazzoni Hospital, Ascoli Piceno, Italy; Professor O Hermine, Hôpital Necker, Paris, France; Professor G Sucak, Gazi Universitesi Tip Fakültesi, Ankara, Turkey; Professor T Gedde-Dahl, Department of Medicine, Rikshospitalet, The National Hospital, Oslo, Norway; Professor C Richard Espiga, Hospital U Marqués de Valdecilla, Santander, Spain; Professor K Carlson, University Hospital, Uppsala, Sweden; Professor M Nikolousis, Birmingham Heartlands Hospital, Birmingham, UK; Professor M Brune, Sahlgrenska University Hospital, Goeteborg, Sweden; Professor C Kratz, Hannover Medical University, Hannover, Germany; Professor P Mazza, Ospedale Nord, Taranto, Italy; Professor D Konstantinov, Specialized Children’s Oncohematology Hospital, Sofia, Bulgaria; Professor D Niederwieser, University Hospital Leipzig, Leipzig, Germany; Professor G Kobbe, Heinrich Heine Universität, Düsseldorf, Germany; Professor K Vettenranta, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Professor M Hallek, Department of Medicine, University of Cologne-I, Cologne, Germany; Professor J-L Bello Lopez, Hospital Clinico Universitario, Santiago De Compostela, Spain; Professor F Abdel-Rahman, King Hussein Cancer Centre, Amman, Jordan; Professor H Ozdogu, Baskent University Hospital, Adana, Turkey; Professor J Lopez-Jimenez, Hospital Ramon y Cajal, Madrid, Spain; Professor A Unal, Department of Hematology and Oncology, Erciyes Medical School, Kayseri, Turkey; Professor S Zver, University Medical Center, Ljubljana, Slovenia; Professor AE Hunter, Leicester Royal Infirmary, Leicester, UK; Professor A Sampol, Hospital Universitario Son Espases, Palma De Mallorca, Spain; ICO – Professor R Duarte Palomino, Hospital Duran i Reynals, Barcelona, Spain; Professor H Campbell, Royal Liverpool Children’s NHS Trust, Liverpool, UK; Professor J Snowden, North Trent BMT Programme (Adults), Sheffield, UK; Professor G Storti, A.O.R.N. 'San.G Moscati', Avellino, Italy; Professor A Velardi, Sezione di Ematologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia; Ospedale Santa Maria della Misericordia, Perugia, Italy; Professor W Wiktor-Jedrzejczak, Central Clinical Hospital, Warsaw, Poland; Professor D Russo, AZ. Spedali Civili- Brescia Universitu of Brescia, Brescia, Italy; Professor G Cardinale, A.R.N.A.S. Civico, Di Cristina, U.O. Ematologia, Palermo, Italy; Professor R Ram, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Professor Z Bolaman, Adnan Menderes University Medical Faculty, Aydin, Turkey; Professor G Michel, Hopital d'Enfants de la Timone, CHU Département Hématologie Oncologie Pédiatrique, Marseille, France; Professor L Kanz, Universität Tübingen, Tübingen, Germany; Professor X Poiré, Cliniques Universitaires St Luc, Brussels, Belgium; Professor M Gramatzki, Division of Stem Cell Transplantation and Immunotherapy, Kiel, Germany; Professor MN Chonghaile, St James Hospital Trinity College, Dublin, Ireland; Professor A Campos, Institute of Portugues de Oncologia do Porto, Porto, Portugal; Professor H Martin, Goethe-Universität, Frankfurt am Main, Germany; Professor M Casini, Hospital San Maurizio, Bolzano, Italy; Professor G Stuhler, Deutsche Klinik für Diagnostik, KMT Zentrum, Wiesbaden, Germany; Professor G Marotta, Policlinico Le Scotte, Siena, Italy; Professor J Moraleda, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain; Professor H Bittencourt, Ste-Justine Hospital, Montréal, Canada; Professor R Salim, Royal Liverpool University Hospital, Liverpool, UK; Professor D Selleslag, A.Z. Sint-Jan, Brugge, Belgium; Professor N Cascavilla, IRCCS, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; Professor G Visani, Pesaro Hospital, Pesaro, Italy; Professor A Lange, DCTK, Wroclaw, Poland; Professor T Masszi, Department of Haematology and Stem Cell Transplant, Budapest, Hungary; Professor D Stamatovic, Military Medical Academy, Belgrade, Serbia and Montenegro; Professor Dr Axel A Fauser, Klinik für Knochenmark Transplantation, Hämatologie und Onkologie, Idar-Oberstein, Germany; Professor C Vallejo Llamas, Hospital Aranzazu, San Sebastian, Spain; Hospital Ampang, Ampang, Malaysia; Professor P Corradini, University of Milano, Milano, Italy; Professor F Benedetti, Policlinico G.B. Rossi, Verona, Italy; Professor K Theunissen, Virga Jesse Hospital, Hasselt, Belgium; Professor S Gonzalez Muniz, Hospital Covadonga, Oviedo, Spain; Professor V Pavone, Hospital C Panico, Tricase (Lecce), Italy; Professor A Vitek, Institute of Hematology and Blood Transfusion, Prague, Czech Republic; Professor C Bokemeyer, Universitätsklinikum Hamburg-Eppendorf, Onkologisches Zentrum, II. Medizinische Klinik und Poliklinik, Hamburg, Germany; Professor M Musso Ospedale La Maddalena, Department of Oncologico, Palermo, Italy; Professor T O’Brien, Sydney Children’s Hospital, Randwick, Australia; Professor P Shaw, The Children’s Hospital at Westmead, Sydney, Australia; Professor A Sandstedt, University Hospital, Linköping, Sweden; Professor G de Rosa, Division of Hematology, Federico II' Medical School, University of Napoli, Napoli, Italy; Professor J Gribben, St Bartholomew’s and The Royal London Hospital, London, UK; Professor J Finke, Department of Medicine-Hematology, Oncology, University of Freiburg, Freiburg, Germany; Professor F Salvi, H SS. Antonio e Biagio, Alessandria, Italy; Professor L Fouillard, Centre Hospitalier de Meaux, Haematology, Meaux, France; Professor H Tilly, Pédiatrie et Génétique Médicale, Rouen, France.
Author Contributions
AR, EG, VR, FC and MM designed the study, AR prepared and analyzed data, AR wrote the paper, AR and ML, performed the statistical analysis, GS, WA, AB, DB, AB, HH, DK, YK, MM, AP, JS, SS, HS, JS, LV and AN provided cases for the study, SP and FV helped with data and manuscript preparation. All the authors edited and approved the manuscript.
Author information
Authors and Affiliations
Consortia
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies this paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Ruggeri, A., Labopin, M., Sanz, G. et al. Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia. Leukemia 29, 1891–1900 (2015). https://doi.org/10.1038/leu.2015.98
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2015.98
This article is cited by
-
Comparison of haploidentical transplantation and single cord blood transplantation for myelofibrosis
Bone Marrow Transplantation (2024)
-
Reduced post-transplant cyclophosphamide doses in haploidentical hematopoietic cell transplantation for elderly patients with hematological malignancies
Bone Marrow Transplantation (2023)
-
Hydrogel-based microenvironment engineering of haematopoietic stem cells
Cellular and Molecular Life Sciences (2023)
-
Unrelated cord blood transplantation vs. HLA-matched sibling transplantation for adults with B-cell acute lymphoblastic leukemia in complete remission: superior OS for patients with long-term survival
Stem Cell Research & Therapy (2022)
-
Autologous hematopoietic stem cell transplantation followed by interleukin-2 for adult acute myeloid leukemia patients with favorable or intermediate risk after complete remission
Annals of Hematology (2022)