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Cytogenetics and Molecular Genetics

Hyperdiploid karyotypes in acute myeloid leukemia define a novel entity: a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH)

Leukemia volume 22, pages 132–137 (2008)Cite this article

Abstract

A series of 38 patients with acute myeloblastic leukemia (AML) with 49 or more chromosomes and without structural abnormalities was selected within the Groupe Francophone de Cytogénétique Hématologique (GFCH) to better define their characteristics. The median age of the patients was 65 years, and all FAB subtypes were represented. Although all chromosomes were gained, some seems to prevail: chromosome 8 (68%), 21 (47%), 19 (37%), and 13 and 14 (34% each). Since MLL rearrangement leads patients in a group with an unfavorable prognosis, search for cryptic rearrangements of MLL was performed in 34 patients and showed abnormalities in 5 (15%). When we applied the most frequent definition of complex karyotypes (three or more abnormalities), all patients with high hyperdiploid AML fall in the unfavorable category. Among the 18 patients without MLL rearrangement receiving an induction therapy, 16 (89%) reached CR and 6 (33%) were still alive after a 31-month median follow-up (14–61 months). Although this study was retrospective, these results suggest that high hyperdiploid AML without chromosome rearrangement seems to be a subgroup of uncommon AML (less than 1%), and may be better classified in the intermediate prognostic group.

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Authors and Affiliations

  1. Departments of Cytogenetic and Cytologic, Hôpital Robert Debré, Reims, France

    I Luquet, P Cornillet-Lefebvre & S Daliphard

  2. Departments of Cytogenetic and Cytologic, Hôpital Jeanne de Flandre, Lille, France

    J L Laï

  3. Departments of Cytogenetic and Cytologic, Hôpital Bretonneau, Tours, France

    C Barin

  4. Departments of Cytogenetic and Cytologic, CHU, Angers, France

    L Baranger & F Geneviève

  5. Departments of Cytogenetic and Cytologic, Hôpital Kremlin-Bicêtre, Kremlin-Bicêtre, France

    C Bilhou-Nabera

  6. Departments of Cytogenetic and Cytologic, Hôpital Haut-Levêque, Bordeaux, France

    E Lippert

  7. Departments of Cytogenetic and Cytologic, Hôpital de Hautepierre, Strasbourg, France

    C Gervais

  8. Departments of Cytogenetic and Cytologic, Hôpital Hôtel-Dieu, Nantes, France

    P Talmant & R Garand

  9. Departments of Cytogenetic and Cytologic, Hôpital St-Antoine, Paris, France

    C Perot

  10. Departments of Cytogenetic and Cytologic, Hôpital Nord, Saint-Etienne, France

    N Nadal

  11. Departments of Cytogenetic and Cytologic, Institut Paoli-Calmettes and Université de la Méditerranée, Marseille, France

    M J Mozziconacci & M Lafage-Pochitaloff

  12. Departments of Cytogenetic and Cytologic, Hôpital Avicenne, Bobigny, France

    V Eclache

  13. Departments of Cytogenetic and Cytologic, Hôpital du Bocage, Dijon, France

    F Mugneret

  14. Departments of Cytogenetic and Cytologic, CHU, Grenoble, France

    C Lefebvre

  15. Departments of Cytogenetic and Cytologic, CHU, Liège, Belgium

    C Herens

  16. Departments of Cytogenetic and Cytologic, Ghent University Hospital, Ghent, Belgium

    F Speleman

  17. Departments of Cytogenetic and Cytologic, Cliniques Universitaires St-Luc-UCL, Bruxelles, Belgium

    H Poirel

  18. Departments of Cytogenetic and Cytologic, CH Lyon Sud, Lyon, France

    I Tigaud

  19. Departments of Cytogenetic and Cytologic, Hôpitaux Universitaires, Genève, Switzerland

    C Cabrol

  20. Departments of Cytogenetic and Cytologic, Hôpital André Mignot, Versailles, France

    P Rousselot & C Terre

  21. Departments of Cytologic, Hôpital Henri Mondor, Créteil, France

    M Imbert

  22. Departments of Cytogenetic and Cytologic, Hôpital Necker Enfants Malades, Paris, France

    R Berger

Authors
  1. I Luquet
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  2. J L Laï
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  3. C Barin
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  4. L Baranger
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  6. E Lippert
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  7. C Gervais
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  8. P Talmant
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  9. P Cornillet-Lefebvre
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  10. C Perot
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  11. N Nadal
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  12. M J Mozziconacci
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  13. M Lafage-Pochitaloff
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  14. V Eclache
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  15. F Mugneret
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  16. C Lefebvre
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  17. C Herens
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  18. F Speleman
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  19. H Poirel
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  20. I Tigaud
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  21. C Cabrol
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  22. P Rousselot
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  23. S Daliphard
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  24. M Imbert
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  25. R Garand
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  26. F Geneviève
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  27. R Berger
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  28. C Terre
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Corresponding author

Correspondence to C Terre.

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Luquet, I., Laï, J., Barin, C. et al. Hyperdiploid karyotypes in acute myeloid leukemia define a novel entity: a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH). Leukemia 22, 132–137 (2008). https://doi.org/10.1038/sj.leu.2404974

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  • DOI: https://doi.org/10.1038/sj.leu.2404974

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