TABLE OF CONTENTS
Volume 20, Issue 4 (April 2006)
Leading Articles
Flow cytometry evaluation of erythroid dysplasia in patients with myelodysplastic syndrome
M G Della Porta, L Malcovati, R Invernizzi, E Travaglino, C Pascutto, M Maffioli, A Gallì, S Boggi, D Pietra, L Vanelli, C Marseglia, S Levi, P Arosio, M Lazzarino and M Cazzola
Leukemia 20: 549-555; advance online publication, February 23, 2006; doi:10.1038/sj.leu.2404142
Relapse of acute promyelocytic leukemia with PML-RAR
mutant subclones independent of proximate all-trans retinoic acid selection pressure
R E Gallagher, E L Schachter-Tokarz, D-C Zhou, W Ding, S H Kim, B J Sankoorikal, W Bi, K J Livak, J L Slack and C L Willman
Leukemia 20: 556-562; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404118
Reviews
Role of cytokines in the treatment of acute leukemias: a review
F Ravandi
Leukemia 20: 563-571; advance online publication, February 23, 2006; doi:10.1038/sj.leu.2404152
Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells
S D Turner and D R Alexander
Leukemia 20: 572-582; advance online publication, February 16, 2006; doi:10.1038/sj.leu.2404125
Original Articles
Molecular Targets for Therapy (MTT)
Hyperforin inhibits MMP-9 secretion by B-CLL cells and microtubule formation by endothelial cells
C Quiney, C Billard, P Mirshahi, J-D Fourneron and J-P Kolb
Leukemia 20: 583-589; advance online publication, February 9, 2006; doi:10.1038/sj.leu.2404134
Induction of cell death in adult T-cell leukemia cells by a novel I
B kinase inhibitor
T Sanda, K Asamitsu, H Ogura, S Iida, A Utsunomiya, R Ueda and T Okamoto
Leukemia 20: 590-598; advance online publication, February 2, 2006; doi:10.1038/sj.leu.2404129
Acute Non Lymphocytic Leukemias
Telomerase targeting by retinoids in cells from patients with myeloid leukemias of various subtypes, not only APL
F Pendino, J Hillion, C Dudognon, J Delaunay, S Mourah, M-P Podgorniak, I Lafon, C Chomienne, M Lanotte, H Dombret, P Rousselot and E Ségal-Bendirdjian
Leukemia 20: 599-603; advance online publication, February 16, 2006; doi:10.1038/sj.leu.2404127
AML patients with CEBP
mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: a comparative analysis on paired diagnosis and relapse samples
L-Y Shih, D-C Liang, C-F Huang, J-H Wu, T-L Lin, P-N Wang, P Dunn, M-C Kuo and T-C Tang
Leukemia 20: 604-609; advance online publication, February 2, 2006; doi:10.1038/sj.leu.2404124
Acute Leukemias
Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C
H Pelicano, J S Carew, T J McQueen, M Andreeff, W Plunkett, M J Keating and P Huang
Leukemia 20: 610-619; advance online publication, February 16, 2006; doi:10.1038/sj.leu.2404140
Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system
T M Owaidah, A Al Beihany, M A Iqbal, N Elkum and G T Roberts
Leukemia 20: 620-626; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404128
Myelodysplasias
High frequency of several PIG-A mutations in patients with aplastic anemia and myelodysplastic syndrome
M Okamoto, T Shichishima, H Noji, K Ikeda, A Nakamura, K Akutsu and Y Maruyama
Leukemia 20: 627-634; advance online publication, February 9, 2006; doi:10.1038/sj.leu.2404135
Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations
H Niimi, H Harada, Y Harada, Y Ding, J Imagawa, T Inaba, T Kyo and A Kimura
Leukemia 20: 635-644; advance online publication, February 9, 2006; doi:10.1038/sj.leu.2404136
Acute Lymphoblastic Leukemias
Dendritic cell deficiencies in pediatric acute lymphoblastic leukemia patients
B Maecker, D Mougiakakos, M Zimmermann, M Behrens, S Hollander, A Schrauder, M Schrappe, K Welte and C Klein
Leukemia 20: 645-649; advance online publication, February 23, 2006; doi:10.1038/sj.leu.2404146
Chronic Myeloid Leukemia, BCR/ABL Studies and Myeloproliferative Disorders
The Bcr-Abl mutations T315I and Y253H do not confer a growth advantage in the absence of imatinib
C Miething, S Feihl, C Mugler, R Grundler, N von Bubnoff, F Lordick, C Peschel and J Duyster
Leukemia 20: 650-657; advance online publication, February 16, 2006; doi:10.1038/sj.leu.2404151
The presence of a BCR-ABL mutant allele in CML does not always explain clinical resistance to imatinib
J S Khorashad, M Anand, D Marin, S Saunders, T Al-Jabary, A Iqbal, S Margerison, J V Melo, J M Goldman, J F Apperley and J Kaeda
Leukemia 20: 658-663; advance online publication, February 9, 2006; doi:10.1038/sj.leu.2404137
Limited clinical value of regular bone marrow cytogenetic analysis in imatinib-treated chronic phase CML patients monitored by RQ-PCR for BCR-ABL
D M Ross, S Branford, S Moore and T P Hughes
Leukemia 20: 664-670; advance online publication, February 16, 2006; doi:10.1038/sj.leu.2404139
hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia
L J Campbell, C Fidler, H Eagleton, A Peniket, R Kusec, S Gal, T J Littlewood, J S Wainscoat and J Boultwood
Leukemia 20: 671-679; advance online publication, February 23, 2006; doi:10.1038/sj.leu.2404141
Chronic Lymphocytic Leukemia, Normal B and T Cells
Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference
J E Castro, C E Prada, R A Aguillon, S Kitada, T Fukuda, M Motta, C Wu, F Dicker, G Sun, J Y J Wang, D A Carson, J C Reed and T J Kipps
Leukemia 20: 680-688; advance online publication, February 23, 2006; doi:10.1038/sj.leu.2404144
ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage
C Scielzo, A Camporeale, M Geuna, M Alessio, A Poggi, M R Zocchi, M Chilosi, F Caligaris-Cappio and P Ghia
Leukemia 20: 689-695; advance online publication, February 16, 2006; doi:10.1038/sj.leu.2404138
Molecular Cytogenetics
NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique
S P Romana, I Radford-Weiss, R Ben Abdelali, C Schluth, A Petit, N Dastugue, P Talmant, C Bilhou-Nabera, F Mugneret, M Lafage-Pochitaloff, M-J Mozziconacci, J Andrieu, J-L Lai, C Terre, K Rack, P Cornillet-Lefebvre, I Luquet, N Nadal, F Nguyen-Khac, C Perot, J Van den Akker, S Fert-Ferrer, C Cabrol, C Charrin, I Tigaud, H Poirel, M Vekemans, O A Bernard, R Berger and on behalf of the Groupe Francophone de Cytogénétique Hématologique (GFCH)
Leukemia 20: 696-706; advance online publication, February 9, 2006; doi:10.1038/sj.leu.2404130
Bone Marrow Transplantation
Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia
U Platzbecker, C Thiede, M Füssel, G Geissler, T Illmer, B Mohr, M Hänel, R Mahlberg, U Krümpelmann, F Weissinger, M Schaich, C Theuser, G Ehninger and M Bornhäuser
Leukemia 20: 707-714; advance online publication, February 16, 2006; doi:10.1038/sj.leu.2404143
Myeloma
Decoupling of normal CD40/interleukin-4 immunoglobulin heavy chain switch signal leads to genomic instability in SGH-MM5 and RPMI 8226 multiple myeloma cell lines
W Y K Hwang, C A Gullo, J Shen, C K Poh, S C Tham, G Cow, M Au, E W E Chan and G Teoh
Leukemia 20: 715-723; advance online publication, February 2, 2006; doi:10.1038/sj.leu.2404099
Letters to the Editor
Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival
H Nückel, U H Frey, L Sellmann, M Bau, J Dürig, U Dührsen and W Siffert
Leukemia 20: 724; advance online publication, February 2, 2006; doi:10.1038/sj.leu.2404126
Near-tetraploid acute myeloid leukemias: an EGIL retrospective study of 25 cases
M-C Béné, G Castoldi, A Derolf, R Garand, T Haas, T Haferlach, W Knapp, E Kuhlein, P Leme
, W-D Ludwig, I Marinov, E Matutes, K Michalová, A Porwit-MacDonald, A Orfao, C Schoch, P Talmant, M B van't Veer, Z Zemanová and M Zühlsdorf for the European Group for the Immunological Characterization of Leukaemias (EGIL)
Leukemia 20: 725-728; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404110
Monoclonal B-cell lymphocytosis (MBL) in CLL families: substantial increase in relative risk for young adults
R de Tute, M Yuille, D Catovsky, R S Houlston, P Hillmen and A C Rawstron
Leukemia 20: 728-729; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404116
Immunotherapy of B-cell malignancies with genetically engineered human CD8+ natural killer T cells
M Pieper, C Scheffold, S Duwe, C Rossig, G Bisping, M Stelljes, T F Tedder, H Jurgens, W E Berdel and J Kienast
Leukemia 20: 729-732; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404114
Impaired activating receptor expression pattern in natural killer cells from patients with multiple myeloma
C Fauriat, F Mallet, D Olive and R T costello
Leukemia 20: 732-733; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404096
Acute myelogenous leukemia in a patient with Li–Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report
N Ånensen, J Skavland, C Stapnes, A Ryningen, A-L Børresen-Dale, B T Gjertsen and Ø Bruserud
Leukemia 20: 734-736; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404117
JAK2 V617F mutation, PRV-1 overexpression and endogenous erythroid colony formation show different coexpression patterns among Ph-negative chronic myeloproliferative disorders
B Bellosillo, C Besses, L Florensa, F Solé and S Serrano
Leukemia 20: 736-737; advance online publication, February 2, 2006; doi:10.1038/sj.leu.2404123
Imperfect correlation between p53 dysfunction and deletion of TP53 and ATM in chronic lymphocytic leukaemia
A Carter, K Lin, P D Sherrington, M Atherton, K Pearson, A Douglas, A Burford, V Brito-Babapulle, E Matutes, D Catovsky and A R Pettitt
Leukemia 20: 737-740; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404120
A death from Langerhans cell histiocytosis and tuberculosis in 18th Century Hungary – what palaeopathology can tell us today
M Spigelman, I Pap and H D Donoghue
Leukemia 20: 740-742; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404103
CD38+ chronic lymphocytic leukaemia cells co-express high levels of ZAP-70 and are functionally distinct from their CD38- counter-parts
C Pepper, P Brennan, S Alghazal, R Ward, G Pratt, J Starczynski, T Lin, C Rowntree and C Fegan
Leukemia 20: 743-744; advance online publication, February 2, 2006; doi:10.1038/sj.leu.2404133
Donor cell-derived acute myeloid leukemia after unrelated umbilical cord blood transplantation
T Ando, T Yujiri, N Mitani, H Takeuchi, J Nomiyama, M Suguchi, A Matsubara and Y Tanizawa
Leukemia 20: 744-745; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404121
A case of therapy-related acute myeloid leukemia associated with inv(16), with subsequent development of t(9;22)
M Kim, J Lim, Y Kim, K Han, C-S Kang, H-J Kim and W-S Min
Leukemia 20: 746-748; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404058
Intensive consolidation versus oral maintenance therapy in patients 61 years or older with acute myeloid leukemia in first remission: results of second randomization of the AML HD98-B treatment Trial
R F Schlenk, S Fröhling, F Hartmann, J Th Fischer, A Glasmacher, F del Valle, K Götze, C Nerl, R Schoch, H Pralle, H G Mergenthaler, M Hensel, E Koller, H Kirchen, A Matzdorff, H Salwender, H G Biedermann, S Kremers, D Haase, A Benner, K Döhner and H Döhner
Leukemia 20: 748-750; advance online publication, January 26, 2006; doi:10.1038/sj.leu.2404122
Preferential expression of a high number of ATP binding cassette transporters in both normal and leukemic CD34+CD38- cells
E P L M de Grouw, M H G P Raaijmakers, J B Boezeman, B A van der Reijden, L T F van de Locht, T J M de Witte, J H Jansen and R A P Raymakers
Leukemia 20: 750-754; advance online publication, February 9, 2006; doi:10.1038/sj.leu.2404131
