TABLE OF CONTENTS
Volume 19, Issue 7 (July 2005)
Reviews |
Editorial |
Commentaries |
Meeting Report |
Original Manuscripts |
Spotlight Correspondence |
Correspondence
Leading Article
Predicting the effect of transcription therapy in hematologic malignancies
A Melnick
Leukemia 19: 1109-1117; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403777
Reviews
Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells
M Kucia, R Reca, V R Jala, B Dawn, J Ratajczak and M Z Ratajczak
Leukemia 19: 1118-1127; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403796
What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis?
S D Turner and D R Alexander
Leukemia 19: 1128-1134; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403797
Editorial
The prognostic impact of minimal residual disease assessment after stem cell transplantation for chronic lymphocytic leukemia: is achievement of molecular remission worthwhile?
P Dreger, M Ritgen, S Böttcher, N Schmitz and M Kneba
Leukemia 19: 1135-1138; doi:10.1038/sj.leu.2403800
Commentaries
Is it chronic idiopathic myelofibrosis, myelofibrosis with myeloid metaplasia, chronic megakaryocytic–granulocytic myelosis, or chronic megakaryocytic leukemia? Further thoughts on the nosology of the clonal myeloid disorders
M A Lichtman
Leukemia 19: 1139-1141; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403804
Centrosome aberrations – hen or egg in cancer initiation and progression?
A Krämer
Leukemia 19: 1142-1144; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403780
Meeting Report
The Seventh International Childhood Acute Lymphoblastic Leukemia Workshop Report: Palermo, Italy, January 29–30, 2005
M Aricó, A Baruchel, Y Bertrand, A Biondi, V Conter, T Eden, H Gadner, P Gaynon, K Horibe, S P Hunger, G Janka-Schaub, G Masera, J Nachman, R Pieters, M Schrappe, K Schmiegelow, M G Valsecchi and C-H Pui
Leukemia 19: 1145-1152; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403783
Original Manuscripts
Acute Non-Lymphocytic Leukemia
Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group
C Callens, S Chevret, J-M Cayuela, B Cassinat, E Raffoux, S de Botton, X Thomas, A Guerci, N Fegueux, A Pigneux, A-M Stoppa, T Lamy, F Rigal-Huguet, A Vekhoff, S Meyer-Monard, A Ferrand, M Sanz, C Chomienne, P Fenaux and H Dombret for the European APL Group
Leukemia 19: 1153-1160; advance online publication, May 12, 2005; doi:10.1038/sj.leu.2403790
The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells
M R Trus, L Yang, F Suarez Saiz, L Bordeleau, I Jurisica and M D Minden
Leukemia 19: 1161-1168; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403773
Significance of chemokine receptor expression in aggressive NK cell leukemia
H Makishima, T Ito, N Asano, H Nakazawa, S Shimodaira, Y Kamijo, Y Nakazawa, T Suzuki, H Kobayashi, K Kiyosawa and F Ishida
Leukemia 19: 1169-1174; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403732
Adult T Cell Leukemia
Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma
V Richard, M V P Nadella, P L Green, M D Lairmore, G Feuer, J G Foley and T J Rosol
Leukemia 19: 1175-1183; advance online publication, May 12, 2005; doi:10.1038/sj.leu.2403787
Chronic Myeloid Leukemia, BCR/ABL Studies and Myeloproliferative Disorders
Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro
H G Jørgensen, E K Allan, S M Graham, J L Godden, L Richmond, M A Elliott, J C Mountford, C J Eaves and T L Holyoake
Leukemia 19: 1184-1191; advance online publication, May 12, 2005; doi:10.1038/sj.leu.2403785
Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability
M Giehl, A Fabarius, O Frank, A Hochhaus, M Hafner, R Hehlmann and W Seifarth
Leukemia 19: 1192-1197; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403779
Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL – Inhibition of P-glycoprotein function by 17-AAG
A Radujkovic, M Schad, J Topaly, M R Veldwijk, S Laufs, B S Schultheis, A Jauch, J V Melo, S Fruehauf and W J Zeller
Leukemia 19: 1198-1206; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403764
Chronic Lymphocytic Leukemia and Normal B Cells
Filgrastim and alemtuzumab (Campath-1H) for refractory chronic lymphocytic leukemia
T S Lin, I W Flinn, M S Lucas, P Porcu, J Sickler, M E Moran, D M Lucas, N A Heerema, M R Grever and J C Byrd
Leukemia 19: 1207-1210; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403782
Protein expression analysis of chromosome 12 candidate genes in chronic lymphocytic leukemia (CLL)
D Winkler, C Schneider, A Kröber, L Pasqualucci, P Lichter, H Döhner and S Stilgenbauer
Leukemia 19: 1211-1215; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403778
High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia
D Heintel, D Kienle, M Shehata, A Kröber, E Kroemer, I Schwarzinger, D Mitteregger, T Le, A Glei
, C Mannhalter, A Chott, J Schwarzmeier, C Fonatsch, A Gaiger, H Döhner, S Stilgenbauer and U Jäger and the German CLL Study Group
Leukemia 19: 1216-1223; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403748
Leukemia Genomics
Genomic gains and losses influence expression levels of genes located within the affected regions: a study on acute myeloid leukemias with trisomy 8, 11, or 13, monosomy 7, or deletion 5q
C Schoch, A Kohlmann, M Dugas, W Kern, W Hiddemann, S Schnittger and T Haferlach
Leukemia 19: 1224-1228; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403810
Proteomics
Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease
O J Semmes, L H Cazares, M D Ward, L Qi, M Moody, E Maloney, J Morris, M W Trosset, M Hisada, S Gygi and S Jacobson
Leukemia 19: 1229-1238; advance online publication, May 12, 2005; doi:10.1038/sj.leu.2403781
Differentiation
Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1
that augments transcriptional activity of CCAAT/enhancer-binding protein-
Y Jiang, Z-H Xue, W-Z Shen, K-M Du, H Yan, Y Yu, Z-G Peng, M-G Song, J-H Tong, Z Chen, Y Huang, M Lübbert and G-Q Chen
Leukemia 19: 1239-1247; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403734
Myeloma
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival
S Wuillème-Toumi, N Robillard, P Gomez, P Moreau, S Le Gouill, H Avet-Loiseau, J-L Harousseau, M Amiot and R Bataille
Leukemia 19: 1248-1252; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403784
Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs
S Kumar, N Raje, T Hideshima, K Ishitsuka, A Roccaro, N Shiraishi, M Hamasaki, H Yasui, N C Munshi, P Richardson, W D Figg and K C Anderson
Leukemia 19: 1253-1261; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403776
Spotlight Correspondence
Durability of molecular remission in chronic myeloid leukemia patients treated with imatinib vs allogeneic stem cell transplantation
T Lange, T Bumm, M Mueller, S Otto, H-K Al-Ali, L Grommisch, S Musiol, C Franke, R Krahl, D Niederwieser and M W N Deininger
Leukemia 19: 1262-1265; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403752
Occurrence of de novo ABL kinase domain mutations in primary bone marrow cells after BCR-ABL gene transfer and Imatinib mesylate selection
S Flamant and A G Turhan
Leukemia 19: 1265-1267; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403786
Abl inhibitor BMS354825 binding mode in Abelson kinase revealed by molecular docking studies
C Gambacorti-Passerini, M Gasser, S Ahmed, S Assouline and L Scapozza
Leukemia 19: 1267-1269; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403775
Correspondence
Leukemia-derived dendritic cells in acute myeloid leukemia exhibit potent migratory capacity
T M Westers, I Houtenbos, N C L Snoijs, A A van de Loosdrecht and G J Ossenkoppele
Leukemia 19: 1270-1272; advance online publication, May 12, 2005; doi:10.1038/sj.leu.2403794
Treatment of relapsed acute myelogeneous leukaemia with MLL/AF6 fusion after stem cell transplantation by intensive reinduction followed by adoptive immunotherapy
F R Schuster, M Führer, W Woessmann, A Reiter, J Harbott, S Viehmann and A Borkhardt
Leukemia 19: 1273-1274; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403791
Reply to Schuster et al
C Schmid and H-J Kolb
Leukemia 19: 1275-1276; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403792
Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia
G S Sellick, H E Spendlove, D Catovsky, K Pritchard-Jones and R S Houlston
Leukemia 19: 1276-1278; advance online publication, May 5, 2005; doi:10.1038/sj.leu.2403788
Maintained rules of development in a mouse B-cell tumor
D F Robbiani, K Colon, M Affer, M Chesi and P L Bergsagel
Leukemia 19: 1278-1280; advance online publication, April 21, 2005; doi:10.1038/sj.leu.2403774
CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia
L J C M van Zutven, E van Drunen, J M de Bont, M M Wattel, M L Den Boer, R Pieters, A Hagemeijer, R M Slater and H B Beverloo
Leukemia 19: 1281-1284; advance online publication, April 21, 2005; doi:10.1038/sj.leu.2403769
Expression profile of survivin in acute leukaemias: the importance of differential splicing
R Lopes, I Castro, P Pontes, J Candeias, N R Lemoine and C Sambade
Leukemia 19: 1284-1286; advance online publication, April 21, 2005; doi:10.1038/sj.leu.2403765
Human hematopoietic cell transplantation results in generation of donor-derived epithelial cells
Y Metaxas, R Zeiser, A Schmitt-Graeff, M Waterhouse, P Faber, M Follo, H Bertz, J Finke and A Spyridonidis
Leukemia 19: 1287-1289; doi:10.1038/sj.leu.2403789
T-cell ZAP-70 overexpression in chronic lymphocytic leukemia (CLL) correlates with CLL cell ZAP-70 levels, clinical stage and disease progression
Y Herishanu, S Kay, O Rogowski, M Pick, E Naparstek, V R Deutsch and A Polliack
Leukemia 19: 1289-1291; advance online publication, April 21, 2005; doi:10.1038/sj.leu.2403762
MLL methylation is not likely a common mechanism for therapy-related AML
A Bogni, C-H Pui and M V Relling
Leukemia 19: 1291-1292; advance online publication, April 21, 2005; doi:10.1038/sj.leu.2403768
Identification of e19a2 BCR–ABL fusions (
-BCR breakpoints) at the DNA level by ligation-mediated PCR
N Boeckx, M W J C Jansen, C Haskovec, P Vandenberghe, V H J van der Velden and J J M van Dongen
Leukemia 19: 1292-1295; advance online publication, April 21, 2005; doi:10.1038/sj.leu.2403761
TEL/AML1 real-time quantitative reverse transcriptase PCR can complement minimal residual disease assessment in childhood ALL
E Fronkova, J Madzo, J Zuna, L Reznickova, K Muzikova, O Hrusak, J Stary and J Trka
Leukemia 19: 1296-1297; advance online publication, April 28, 2005; doi:10.1038/sj.leu.2403759
