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Absence of microsatellite instability during the progression of chronic myelocytic leukemia

Leukemia volume 11, pages 151–152 (1997)Cite this article

Abstract

Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.

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Authors and Affiliations

  1. Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine, USA

    N Mori, S Takeuchi, T Tasaka & HP Koeffler

  2. Department of Hematology, Tokyo Women’s Medical College, Japan

    N Mori & H Mizoguchi

  3. Department of Clinical Pathology, Cedars-Sinai Medical Center, UCLA School of Medicine, USA

    S Lee & S Spira

  4. Department of Hematology, Hadassah Medical Organization, Israel

    D Ben-Yehuda

  5. Department of Hematology/Oncology, UCLA School of Medicine, USA

    G Schiller

Authors
  1. N Mori
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  2. S Takeuchi
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  3. T Tasaka
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  4. S Lee
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  5. S Spira
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  6. D Ben-Yehuda
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  7. H Mizoguchi
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  8. G Schiller
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  9. HP Koeffler
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Cite this article

Mori, N., Takeuchi, S., Tasaka, T. et al. Absence of microsatellite instability during the progression of chronic myelocytic leukemia. Leukemia 11, 151–152 (1997). https://doi.org/10.1038/sj.leu.2400524

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  • DOI: https://doi.org/10.1038/sj.leu.2400524

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