Volume 89 Issue 1, January 2009
Cover: Brown staining shows strong expression of the TGFβ/BMP receptor Acvrl1 (also known as Alk1) in a distal artery as well as alveolar capillaries in the mouse lung. Mutations in the human ACVRL1 gene are associated with two different vascular disorders—Hereditary Haemorrhagic Telangiectasia (HHT) and familial Pulmonary Artery Hypertension (fPAH). Remodelling of the distal arteries occurs in both disorders pointing to the importance of specific Acvrl1 expression in this region. For more information see the paper by Mahmoud et al, pages 15–25
Inside Lab Invest
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