Keratin 19-expressing mesenchymal stem cells (green) from the bone marrow retain an enhanced capacity to engraft in the gastric epithlium after blastocyst injection. However, these engrafted cells do not appear to differentiate into other cell types of the glandular unit, such as H/K ATPase-expressing parietal cells (red). For more information see the paper by Okumura et al on page 1410.

Cover: The cover shows putative extracellular (perforin-independent) roles for granzyme B in age-related chronic inflammatory disorders. For more information see the paper by Boivin et al in this issue.

Antiangiogenic treatments alter amount and distribution of microvessels in human tumor xenografts stained in-vivo with sulphobiotin. Construction of false-color maps showing the space-filling properties (middle-right) and vesselcovered area (bottom-center) allows for a better description of the antiangiogenic results. For more information on the quantification and comparisons of vessel distributions see the paper by Righi et al in the September 2009 issue on page 1063.

The transcription factor FOXO3 regulates colonic inflammation and may play a role in inflammatory bowel disease. Foxo3-deficient mice developed severe mucosal inflammation in a colitis model, compared to normal colon shown on the cover, suggesting a potential therapeutic target. For more information on the mechanisms of FOXO3 regulation see the paper by Snoeks et al on page 1053.

The cover shows bacterial invasion of amniotic epithelial cells following microbial invasion of the amniotic cavity (SYTO 9/propidium iodide fluorescent staining). Color was added to the cover image for artistic purposes only. For more information see the paper by Kim et al on page 924.

The cover shows an electron micrograph of a human eosinophil isolated from the peripheral blood and stimulated with eotaxin, an eosinophil agonist. Immunonanogold electron microscopy reveals major basic protein within secretory vesicles and mobilized specific granules. Color was added to the figure for artistic purposes only. For more information see the paper by Melo et al. on page 769.

Stereoscopic image of a wild-type mouse embryo at E9.75. From the paper by Kimura et al, on page 645, this issue

The cover shows an electron micrograph revealing mitochondrial ultrastructural changes (including fragmented cristae) in mouse renal tubular epithelial cells following treatment with tenofovir, a drug used to treat HIV/AIDS. Color has been added for artistic purposes only. For more information, see the paper by Kohler et al on page 513.

Cover: Aortic wall stained with picrosirius red and viewed with circularly polarized light; thick collagen fibers appear orange and thin fibers appear green. Collagen content in the tunica adventitia increased significantly in the suprarenal abdominal aorta of apolipoprotein E-deficient mice expressing collagenase-resistant mutant collagen type I after angiotensin II infusion. We propose that increased collagen content combined with a change from three-dimensional to two-dimensional collagen fiber waviness increases aortic stiffness and thereby promotes aneurysm formation. For more information see the paper by Deguchi et al, pages 315–326

Double immunofluorescent image of an adult human pancreas section stained with CK19 (red) and CD29 (green). CD29 is localized to the outer duct wall while CK19 stains the ductal epithelium. For more information see the paper by Seeberger et al, pages 110–121.

Cover: Brown staining shows strong expression of the TGFβ/BMP receptor Acvrl1 (also known as Alk1) in a distal artery as well as alveolar capillaries in the mouse lung. Mutations in the human ACVRL1 gene are associated with two different vascular disorders—Hereditary Haemorrhagic Telangiectasia (HHT) and familial Pulmonary Artery Hypertension (fPAH). Remodelling of the distal arteries occurs in both disorders pointing to the importance of specific Acvrl1 expression in this region. For more information see the paper by Mahmoud et al, pages 15–25