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  • Special |

    Biology has evolved greatly in the past decade as high-throughput technologies were developed and applied to various biological disciplines. These technologies have generated an unprecedented amount and new types of biological data and how to make sense of “big data” is an emerging technological and conceptual challenge. Computational biology largely relies on computational and statistical algorithms to better understand biological processes. The editors of LI commissioned experts in the fields of computational biology and pathology to compile a special issue on computational pathology. We include original research, technical reports and review articles that use, modify, improve, develop, or summarize computational algorithms to solve biomedical questions.

    Image: Mousumi Roy and Fusheng Wang

  • Special |

    The growing burden of neurodegenerative diseases on patients, their families, and health care providers has also stimulated some exciting new developments in the field. This issue of Laboratory Investigation provides a broad view of the field of neurodegenerative diseases with diverse papers focusing on basic research, clinicopathological correlation, neuropathological diagnosis.

    Image: Xinglong Wang

  • Special |

    This collection of LI papers focuses on developments in our understanding of the underlying pathophysiological processes that contribute to cardiovascular disease.

    Image: Kathy K. Griendling