George F Murphy

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Latest Research

  • Article |

    The authors present a rare case of intracranial solitary fibrous tumors/hemangiopericytomas (SFT/HPC) with intraspinal metastasis. A DSTYK mutation (Met296Ile) was identified as a potential driver of intraspinal metastasis. This DSTYK mutation promotes cell migration and invasion of SFT/HPC cells via activation of ERK1/2/MMP2/9 signaling, which may provide new biological insights for SFT/HPC study.

    • Guodong Tang
    • , Yufei Yang
    • , Li Shang
    • , Fu Jun
    •  & Qing Liu
  • Article |

    In this work, the authors propose a new framework based on deep-learning to comprehensively assess the microvascular condition of the glioma patients by automated analysis of the H&E stained whole slide images. They show that microvascularity has a tight relationship with the diagnosis of glioma and can be used as an important prognostic indicator.

    • Xieli Li
    • , Qisheng Tang
    • , Jinhua Yu
    • , Yuanyuan Wang
    •  & Zhifeng Shi
  • Article |

    The authors report a previously unappreciated miR-26a-mediated regulatory model in which miR-26a promotes invasion/metastasis by inhibiting the phosphatase PTEN and inhibits cell proliferation by repressing the methyltransferase EZH2 in hepatocellular carcinoma. Although therapeutic miR-26a delivery significantly suppresses tumorigenesis in mice, further studies are warranted before it is a relevant as a target for HCC therapy.

    • Wen-Tao Zhao
    • , Xiao-Lin Lin
    • , Yu Liu
    • , Liu-Xin Han
    • , Jing Li
    • , Tao-Yan Lin
    • , Jun-Wen Shi
    • , Sheng-Chun Wang
    • , Mei Lian
    • , Heng-Wei Chen
    • , Yan Sun
    • , Kang Xu
    • , Jun-Shuang Jia
    • , Rong-cheng Luo
    •  & Dong Xiao
  • Article |

    The biologic features of diffuse large B-cell lymphoma (DLBCL) with PD-L1 expression remains unknown. This study demonstrates that DLBCL with PD-L1 expression features an activated B-cell receptor signal pathway, and that inhibiting BCR and blocking PD-L1 expression may synergize to target DLBCL.

    • Wei-Ge Wang
    • , Xiang-Nan Jiang
    • , Dong Sheng
    • , Chen-Bo Sun
    • , Jimmy Lee
    • , Xiao-Yan Zhou
    •  & Xiao-Qiu Li
  • Technical Report |

    The authors present the first in-depth analyses of liver pathology in a murine model of classical Farber disease. Characterizing their previously developed acid ceramidase-deficient Farber mice, they identify inflammation, fibrosis, and abnormal lipid profiles in livers/hepatocytes and highlight altered inflammatory, lipid, and sphingolipid gene expression pathways.

    • Fabian P. S. Yu
    • , Salvatore Molino
    • , Jakub Sikora
    • , Shauna Rasmussen
    • , Jitka Rybova
    • , Everett Tate
    • , Aron M. Geurts
    • , Patricia V. Turner
    • , William M. Mckillop
    •  & Jeffrey A. Medin
  • Technical Report |

    The authors examined the feasibility of co-staining miRNAs by fluorescent miRNA in situ hybridization (miRisH) and their target proteins by immunohistofluorescence (IHF) on tissue microarrays from prostate cancer patients, which would allow for the study of miRNA expression patterns and their target proteins at the single-cell level. The miRNAs and corresponding target proteins include the pairs miR-145/ERG, miR-143/uPAR and miR-375/SEC23A.

    • Markus Eckstein
    • , Verena Sailer
    • , Boye Schnack Nielsen
    • , Thomas Wittenberg
    • , Veit Wiesmann
    • , Verena Lieb
    • , Elke Nolte
    • , Arndt Hartmann
    • , Glen Kristiansen
    • , Nicolas Wernert
    • , Bernd Wullich
    • , Helge Taubert
    •  & Sven Wach

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