The cover shows GeoMx digital spatial profiling of epiretinal membranes from patients with proliferative vitreoretinopathy. For more information, see the paper by Dong et al, p 1296, this issue.

The cover shows myoepithelial cells from Myh11- CreERT2/tdTomatofl/fl male mice after tamoxifen injection. For more information, see the paper by Yasuhara et al, p 1245, this issue.

The cover shows 24-28 month old apoB100 mice with retinal pigment epithelial morphology and immune cell morphology. For more information, see the paper by Choudhary et al, p 1132, this issue, that describes a mouse model featuring age-related retinal pathologies.

The cover shows colocalization of p-Drp1 (green) and mitochondria (red) in a mouse model of ischemia-reperfusion injury. For more information, see the paper by Li and Liu, p. xxx, this issue.

The cover shows characteristic histopathologic features of COVID-19-associated cardiac injury in critically ill patients. For more information, see the paper by Hanson et al, p 814, this issue.

The cover shows MIBI-TOF imaging data from an archival human tissue microarray of squamous cell carcinoma. For more information, see the paper by Liu et al, this issue (p 762).

The cover shows a gradient-weighted class activation map for well-differentiated adenocarcinoma. Hot regions correspond to key features for deep learning models to recognize well-differentiated adenocarcinoma. For more information, see the paper by Su et al, p 641, this issue.

In this issue, the paper by Li et al (p 534) illustrates that interactions between leucines within the signal peptides of megalin and stannio-calcin-1 are crucial for regulation of mitochondrial metabolism. The cover shows by deconvolution confocal microscopy that stannio-calcin-1 fails to enter the cell or reach the mitochondria when applied to Lrp2-knockout mouse embryonal fibroblasts expressing mutant megalin.

The cover shows expression of E-cadherin, N-cadherin, α-smooth muscle actin and p-Smad2 by immunofluorescence in untreated or high glucose-treated lens epithelial cells after treatment with a negative control or a miR-204-3p mimic. For more information see the paper by Li et al, this issue (p 452).

The paper by Mohapatra et al. (p 298, this issue) describes how fluvastatin sensitizes pancreatic cancer cells toward radiation therapy and suppresses radiation- and/or TGF-β-induced tumor-associated fibrosis. The cover shows images of developing zebrafish embryos as a model for this study.

In this issue (p 172), Innes et al present an experimental approach to simultaneously barcode and phenotype glioma initiating cells to assess their functional properties The cover shows the clonal populations that emerge during passaging of barcode-labelled cells.

In this issue, the paper by Bai et al. (p 57) describes how hepatitis B virus crosses placenta to cause infection in utero. The cover shows co-localization of the GTPase Rab7 and HBsAg in Swan 71 cells infected with hepatitis B virus.