About the cover
Free online issue
Volume 88, No 5
May 2008
ISSN: 0023-6837
EISSN: 1530-0307
ISI 2006 Impact Factor: 4.453*
5/65 in Pathology
12/76 in Medicine, Research & Experimental
Editor:
James M. Crawford, MD, PhD
*Journal Citation Reports, Thomson 2007
FEATURED ARTICLES
RESEARCH ARTICLE
17q12 amplicons in breast cancer FREERESEARCH ARTICLE
Vascular complications in diabetic mice FREERESEARCH ARTICLE
Nodal CD4+ T cells in Hodgkin's lymphoma FREEPATHOBIOLOGY IN FOCUS
Models of tumor heterogeneity and evolution FREECancer is a disease of genes. Based on accumulated knowledge on the genetic composition of cancer cells, the clonal evolution model of tumorigenesis was established, which explains multiple aspects of human disease and clinical observations. However, the recently popularized cancer stem cell hypothesis questions that all or most tumor cells can participate in tumor evolution.News
Genomic mapping identifies cancer forerunners. A genome-wide map of human bladder cancer has identified key genetic risk areas for the disease's development. This research provides important new insight into the earliest genetic origins of cancer, which could assist in the detection and prevention of bladder and other cancers. Read the press release and article from Laboratory Investigation for free to learn more.
Free access to Laboratory Investigation articles 12 months post-publication.
Read the 5 most cited articles from 2007
Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine Leukocidin
Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries
RNA expression analysis of formalin-fixed paraffin-embedded tumors
Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma
Wnt signaling and human diseases: what are the therapeutic implications?
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Laboratory Investigation's sister publication, Modern Pathology, is dedicated to the publication of all aspects of diagnostic human pathology, contemporary issues pertinent to diagnostic accuracy, reviews, illustrative case studies, and clinical medicine directly related to pathology practice and Academy news.
Gene expression profiling in hepatocellular carcinoma
PPAR-γ in dedifferentiated liposarcoma
PAX3 and melanoma
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Research and Reviews
Latest research highlights and reviews from the NPG family of journals
- Lazarus's Gate: Challenges and Potential of Epigenetic Reprogramming of Somatic Cells Source: Clinical Pharmacology & Therapeutics
- Science and society: Heavy ion carcinogenesis and human space exploration Source: Nature Reviews Cancer
- PML targeting eradicates quiescent leukaemia-initiating cells Source: Nature
