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Volume 53 Issue 1, January 2024

The PREMISE database of Macaca Fascicularis PET/MRI brain imaging

Nonhuman primate neuroimaging is a rapidly growing and extremely promising area of neuroscience research that suffers from a lack of data. Neuroimaging database sharing can accelerate research in this field, while limiting the number of animals used. A new Article presents The PREMISE database, a PET/MR dataset of Macaca Fascicularis brain images structured according to BIDS standards and available for researchers.

See Becker et al.

Cover image: Marina Spence. Cover design: Marina Spence

Volume 53 Issue 1

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Protocol Review

  • While emotional support animals can provide comfort for those with mental or emotional disabilities, several factors must be considered when determining the necessary oversight of these animals in institutional academic or research buildings. We invited experts from Wayne State University (Erin Katz), University of California San Francisco (Carine Serageldine) and the University of Oregon (Stephanie Womack, Audrey Harris and Kathy Snell) along with Acting Director, OLAW (Axel Wolff) to respond to a perplexing situation at Great Eastern University.

    • Lauren Danridge
    • Bill Greer
    • Axel Wolff
    Protocol Review

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Research Highlights

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Comment

  • The 3R principles provide an ethical framework for animal research throughout the world. However, despite the increasing awareness of these principles, there is still a lot of room for improving their implementation, especially when it comes to reduction. By combining Bayesian statistics with a shift in experimental design, here we present an entirely new idea to reduce animal numbers within experiments.

    • S. Helene Richter
    Comment Open Access
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Articles

  • Poor replicability in animal research can be a result of low external validity driven by rigorous standardization of study populations. This study investigates how heterogenization of study populations by using mice from different breeding sites might affect the replicability of animal studies conducted in a single facility. The findings suggest that heterogenization by breeding site has limited capacity to improve replicability in animal research.

    • Ivana Jaric
    • Bernhard Voelkl
    • Hanno Würbel
    Article Open Access
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