Mouse models are invaluable to enhance our understanding of the biology of cancer, including high-grade serous ovarian cancer (HGSOC) – the most common and lethal form of ovarian cancer. Among these models, syngeneic mouse models provide an effective approach to study tumor formation in immunocompetent mice. The number of syngeneic mouse models of HGSOC is growing rapidly, and there is a need to compare these models to understand their differences. In a new study in Communications Biology, a team of investigators compared the transcriptomic profile of 22 mouse ovarian cancer cell lines, as well as a number of intrabursal and intraperitoneal tumors derived from select cell lines. The analysis shows that the different cell lines exhibit distinct signaling, metabolic and functional properties, including differences in epithelial-mesenchymal transition activation, PD-L1 and MHC class I expression and predicted chemosensitivity. The results also show that orthotopic tumors generated from intrabursal injection have more abundant tumor stroma than intraperitoneal tumors. These data will be particularly useful to guide the selection of appropriate HGSOC models for specific experimental aims.
Original reference: Cook, D.P. et al. Commun. Biol. 6, 1152 (2023)
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