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Colony management of gene-modified animals is time-consuming, costly and affected by random events related to Mendelian genetics, fertility and litter size. In a new Article, Milchevskaya, Bugnon et al. developed an R package that enables the estimation of group size required for mouse breeding, taking into account Mendelian genetics, fertility and litter size.
Sharing research tools and data with other scientists brings many benefits, such as using fewer animals, improving reproducibility and increasing study sample size, but the practice still needs to be more widely adopted.
The authors developed an R package that enables the estimation of group size required for mouse breeding, taking into account Mendelian genetics, fertility and litter size.