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Volume 52 Issue 7, July 2023

The NeoThy humanized mouse model

Humanized mouse models with human fetal-derived hematopoietic system and lymphoid tissues are well-established, but ethical constraints and difficulties to access human fetal tissues limit their use. In a new Protocol, Del Rio, Huang et al. describe the development of the NeoThy mouse model, a humanized mouse model that incorporates neonatal thymus tissue and umbilical cord blood hematopoietic stem cells as non-fetal human tissue sources.

See Del Rio et al.

COVER IMAGE: Marina Spence. COVER DESIGN: Marina Spence

Volume 52 Issue 7

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  • Unlocking the secrets of the brain requires high precision tools to record neuronal activity. Neuroscientists have tools to capture neuronal activity with unprecedented speed, precision and fidelity. Thanks to a ground-breaking redesign of the linker peptide of GCaMP proteins, a domain seldomly considered for optimization, a new sensor bridges the gap between calcium imaging and electrophysiology.

    • Ana Marta Capaz
    • Nicolas Renier
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