Volume 52 Issue 5, May 2023

A recent study performed directed C5-cytosine methylation of CpG islands to demonstrate that acquired methylation at critical loci could be reestablished for multiple generations in mice. This work provides a manipulatable system to examine how non-genetic information is transmitted across generations to regulate complex phenotypes.

New research using high-dimensional behavioural analyses has further undermined the “females are the more variable sex” trope that often accompanies all-male studies. But when we consider the benefits to the inclusion of females in research, their lesser variability is only the icing on the cake. It’s just good science, really.