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Impact of anesthesia on mouse cardiac electrophysiology
In vivo cardiac electrophysiology studies in mice are useful for studying the mechanisms of cardiac arrhythmias and identifying therapies. However, most procedures are invasive and require anesthesia, which can affect cardiac parameters. In a new article, Tomsits et al. compared the effects of two narcosis regimens on mouse cardiac electrophysiology to determine which regimen is more suitable for electrophysiology and arrhythmia studies.
Tomsits and colleagues investigated the effects of medetomidine/midazolam/fentanyl and isoflurane/fentanyl narcosis on murine cardiac autonomic nervous activity and electrophysiology. The results show that, compared with medetomidine/midazolam/fentanyl narcosis, isoflurane/fentanyl narcosis seems to have no effect on cardiac autonomic nervous function and less influence on cardiac electrophysiology.