Volume 52 Issue 1, January 2023

Modeling septic arthritis in mice

Septic arthritis is a serious type of joint infection, often caused by Staphylococcus aureus. The infection can lead to rapid joint destruction and associated morbidity and mortality, particularly in cases of methicillin-resistant S. aureus (MRSA) infections. In a new protocol, Kwon et al. describe a mouse model of septic arthritis via direct inoculation of MRSA into the knee joint; the authors also detail methods for mouse serum, synovial fluid and knee joint tissue analysis that can be used to evaluate new therapies.

See Kwon et al.

COVER IMAGE: Marina Spence. COVER DESIGN: Marina Spence.