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Volume 51 Issue 6, June 2022

A 3Rs approach for the generation of genetically modified rodents

Generating genetically modified rodents for research projects requires a large number of animals and involves procedures that can cause distress and pain to the animals. In a new Review, Zevnik, Jerchow and Buch provide key recommendations for implementing the 3Rs (Replace, Reduce, Refine) in all steps and procedures for the generation of genetically modified rodents.

See Zevnik et al.

COVER IMAGE: Marina Spence. COVER DESIGN: Marina Spence

Volume 51 Issue 6

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Correspondence

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  • New insights into gut-brain axis and cognition function show that accumulation of Caudovirales bacteriophages in the gut microbiota is associated with improved executive function and memory.

    • Mercedes Gomez de Agüero
    • Aryan Rahimi-Midani
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Review Articles

  • In this Review, the authors provide recommendations for the implementation of the 3Rs in all the steps and procedures in the generation of genetically modified rodents; they also discuss future welfare challenges associated with advances in genome modification techniques.

    • Branko Zevnik
    • Boris Jerchow
    • Thorsten Buch
    Review Article
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