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Depicted on the cover is the sea anemone Aiptasia, harboring microalgae of the species Breviolum minutum (family Symbiodiniaceae). Aiptasia is one animal being developed as a model of coral, its reef-building relatives that are threatened by climate change and other negative human impacts. Just as mice, flies, and other model systems help researchers identify the cellular and molecular mechanisms that contribute to human health and disease, growing communities in the coral field are starting to look for simpler, more tractable options that can be studied in the lab to understand and ultimately help conserve coral reefs in the field.
A ‘day in the life’ of Dr. Jeanna Wheeler, a research scientist at the Seattle Institute for Biomedical & Clinical Research in Seattle, Washington. She works in the lab of Dr. Brian Kraemer, studying models of neurodegenerative diseases in worms and mice. Her most recent work can be found at https://doi.org/10.1126/scitranslmed.aao6545.
Microglia play important but incompletely understood roles in the pathogenesis of neurological disease. New chimeric models using transplanted human stem cell-derived microglia-like cells hold great promise to better model the unique function of human microglia in brain disease.