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In neuroscience, there are many efforts underway to map the brain. Some of the technologies are high-tech and emerging, while others are older classics. There are indeed many ways possible approaches, and many animals to map. From invertebrates with a few hundred neurons to mice with tens of millions, complexity varies. Some projects are looking at small scales; others, larger networks. But maps—and catalogues, atlases, and databases—are growing, providing researchers with new and ever-larger resources to guide them as they seek to better understand the brain and how it functions in health and disease.
The microbiome many consist of small microorganisms, but it can make a big impact on experimental results. Although its exact role is still being teased apart, there are ways researchers can be mindful of the microbial variable in their mouse studies.
Whether the animal has a few hundred neurons or a few billion, mapping the ‘brain’ is a complex endeavor for which there are several different tacks one might take. Data collection continues on.
With the genetics of a laboratory strain but a more diverse microbiome, ‘wildling’ mice could be a novel complement to commonly used specific pathogen-free animals in preclinical studies.