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Volume 48 Issue 10, October 2019

Updates from the aquarium

The zebrafish, Danio rerio, is a model organism used for many research questions. They reproduce quickly and in large numbers, as larvae they are optically clear, and there are well-established techniques to work with the fish and to create genetic models of a variety of different conditions with human relevance. Many researchers use them as an alternative to mammalian models to study health and disease. In other applications, zebrafish are helping research go from ‘tank to bedside’ for personalized medicine. Zebrafish make several appearances in the issue this month, including a recap of the recent Zebrafish Infection and Immunity meeting.

See Torraca et al.

IMAGE: Pablo Bou Mira / Alamy Stock Photo. Cover design: Erin Dewalt

Volume 48 Issue 10

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In This Issue

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News

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Protocol Review

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Comment

  • A recap from the latest webinar addressing Standard Operating Procedures, annual reports, and animals in clinical trials

    • B. Taylor Bennett
    • Matthew R. Bailey
    Comment

  • A recent article by El-Brolosy and colleagues introduced an unexpected twist for our understanding of knock-out mutations by revealing compensatory mechanisms that recruit the expression of other genes to mitigate the consequences of the mutation. We discuss the main findings of the paper and their impact for our interpretations of the effects of mutations in laboratory animals and humans.

    • Rosie K. A. Bunton-Stasyshyn
    • Sara Wells
    • Lydia Teboul
    Comment

  • Experts in the field met at the London School of Hygiene & Tropical Medicine (UK) to discuss the role of zebrafish in advancing fundamental research and discovering therapeutic innovations.

    • Vincenzo Torraca
    • Margarida C. Gomes
    • Serge Mostowy
    Comment
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Technology Feature

  • Caring for lab animals is always a priority. But some, depending on the research they are being used for, can require extra attention. As the animals in question get bigger, the task of keeping them in contained facilities can just get a bit more challenging.

    • Ellen P. Neff

    Collection:

    Technology Feature
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Research Highlights

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News & Views

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Career News

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