Abstract
Members of the RAB protein family regulate vesicular trafficking and reside in specific intercellular compartments. A new member of the RAB family was identified through a public database search, and its full-length cDNA was isolated from a human fetal brain cDNA library. The predicted protein product of the gene consists of 201 amino acid residues, and the protein has 86% similarity to human RAB9 at the amino acid level. We designated the new gene RAB9-like. Northern blot analysis showed that the gene was transcribed ubiquitously in various human tissues. A database search revealed that the gene is divided into three exons and spans approximately 7.2 kb of the genome DNA of chromosome Xq22.1–q22.3 region.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Additional information
Received: March 10, 2000 / Accepted: August 4, 2000
Rights and permissions
About this article
Cite this article
Seki, N., Azuma, T., Yoshikawa, T. et al. cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1–q22.3 region. J Hum Genet 45, 318–322 (2000). https://doi.org/10.1007/s100380070025
Published:
Issue Date:
DOI: https://doi.org/10.1007/s100380070025