Abstract
BACKGROUND: Several studies support the hypothesis that oxidation of low-density lipoprotein (LDL) promotes atherogenesis. Obesity is one of the risk factors of atherosclerosis, but it is not known whether obesity is related to LDL oxidation.
OBJECTIVE AND DESIGN: We investigated the effect of weight reduction and subsequent weight maintenance program on LDL oxidation in 77 obese premenopausal women (BMI 29–46 kg/m2). Another group of seven obese women served as a control group. Oxidized LDL was measured as baseline concentration of conjugated dienes in LDL lipids (ox-LDL). The weight reduction was performed in 12 weeks, using a very-low-energy diet.
RESULTS: The mean weight loss was 13 kg (92 vs 79 kg). During weight reduction, the concentration of LDL cholesterol decreased by 11%, the concentration of ox-LDL decreased by 40%, and the ratio of ox-LDL to LDL by 33%. The concentration of LDL antioxidant capacity (LDL-TRAP) decreased by 8%, but the decrease was caused by the decrease in LDL. The concentration of LDL, ox-LDL or LDL-TRAP did not change in the control group. The weight reduction correlated with the decrease of ox-LDL. During the subsequent 9 month weight maintenance programme, the concentrations of serum LDL (10%), ox-LDL (11%), LDL-TRAP (29%), and the ratio of LDL-TRAP to LDL (21%) decreased.
CONCLUSION: This study strengthens the evidence that the risk of atherogenesis is influenced favourably by weight reduction in obese women. This risk reduction is associated with a reduced oxidation of LDL.
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Acknowledgements
This study was funded by the Juho Vainio Foundation; the Finnish Foundation for Cardiovascular Research; the Turku University Foundation; the Finnish Heart Association; the Yrjö Jahnsson Foundation; the Finnish Ministry of Education; Leiras Oy, Turku, Finland; and Nycomed Pharma AS, Oslo, Norway.
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Vasankari, T., Fogelholm, M., Kukkonen-Harjula, K. et al. Reduced oxidized low-density lipoprotein after weight reduction in obese premenopausal women. Int J Obes 25, 205–211 (2001). https://doi.org/10.1038/sj.ijo.0801533
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DOI: https://doi.org/10.1038/sj.ijo.0801533
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