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Pathophysiology of Peyronie's disease

International Journal of Impotence Research volume 14, pages 406–410 (2002)Cite this article

Abstract

Peyronie's disease is an inflammatory condition characterized by the formation of fibrous, noncompliant nodules in the tunica albuginea which can impede tunical expansion during penile erection, leading to deformity and bending. While the cause of this disease is thought to be due to microvascular trauma and abnormal wound healing, other hypotheses include genetic predisposition. In this review the pathophysiology of Peyronie's disease is discussed as well as current hypothese regarding its origin.

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References

  1. Gelbard M . Peyronie's disease In: Hashmat AI Das S eds The penis. Lea and Febiger: Philadelphia 1993 pp 244–365

    Google Scholar 

  2. Carrier S, Lue TF . For Peyronie's disease, act conservatively Contemporary Urol 1994 9: 54–65

    Google Scholar 

  3. Pryor JP . The management of Peyronie's disease In: Porst H, ed Penile disorders Proceedings of the International Symposium on Penile Disorders, Hamburg, Germany, 26–27 January 1996. Springer Verlag, Berlin 1997 pp 75–86

    Google Scholar 

  4. Devine CJ, Horton CE . Peyronie's disease Clin Plast Surg 1988 15: 405–409

    PubMed  Google Scholar 

  5. Jarow JP, Lowe FC . Penile trauma: an etiologic factor in Peyronie's disease and erectile dysfunction J Urol 1997 158: 1388–1390

    Article  CAS  PubMed  Google Scholar 

  6. Devine CJ, Somers KD, Jordan GH, Schlossberg SM . Proposal: trauma as a cause of Peyronie's lesion J Urol 1997 157: 285–290

    Article  PubMed  Google Scholar 

  7. Vande Berg JS et al. Mechanisms of calcification in Peyronie's disease J Urol 1982 127: 52–54

    Article  CAS  PubMed  Google Scholar 

  8. Krane RJ . The treatment of loss of penile rigidity associated with Peyronie's disease Scand J Urol Nephrol Suppl 1997 179: 147–150

    Google Scholar 

  9. Gasior BL et al. Plaque-associated corporal veno-occlusive dysfunction in idiopathic Peyronie's disease: a pharmacocavernosometric and pharmacocavernosographic study World J Urol 1990 8: 90–97

    Article  Google Scholar 

  10. Lopez JA, Jarow JP . Penile vascular evaluation of men with Peyronie's disease J Urol 1993 149: 53–55

    Article  CAS  PubMed  Google Scholar 

  11. Lyles KW et al. Peyronie's disease is associated with Paget's disease of the bone J Bone Miner Res 1997 12: 929–934

    Article  CAS  PubMed  Google Scholar 

  12. Nyberg LM, Bias WB, Hochberg MC, Walsh PC . Identification of an inherited form of Peyronie's disease with an autosomal dominant inheritance and association with Dupuytren's contracture and histocompatability B7 cross-reactive antigens J Urol 1982 128: 48–52

    Article  PubMed  Google Scholar 

  13. Ralph DJ et al. The genetic and bacteriological aspects of Peyronie's disease J Urol 1997 157: 291–294

    Article  CAS  PubMed  Google Scholar 

  14. Leffell MS . Is there an immunogenetic basis for Peyronie's disease? J Urol 1997 157: 295–297

    Article  CAS  PubMed  Google Scholar 

  15. Schiavino D et al. Immunologic findings in Peyronie's disease: a controlled study Urology 1997 50: 764–768

    Article  CAS  PubMed  Google Scholar 

  16. Stewart S, Malto M, Sandberg L, Colburn KK . Increased serum levels of anti-elastin antibodies in patients with Peyronie's disease J Urol 1994 152: 105–106

    Article  CAS  PubMed  Google Scholar 

  17. Diegelmann RF . Cellular and biochemical aspects of normal and abnormal wound healing: an overview J Urol 1997 157: 298–302

    Article  CAS  PubMed  Google Scholar 

  18. Lindsay MB et al. The incidence of Peyronie's disease in Rochester, Minnesota, 1950 through 1984 J Urol 1991 146: 1007–1009

    Article  CAS  PubMed  Google Scholar 

  19. Smith BH . Subclinical Peyronie's disease Am J Clin Pathol 1969 52: 385–390

    Article  CAS  PubMed  Google Scholar 

  20. Hsu G-L et al. The three-dimensional structure of the tunica albuginea: anatomical and structural levels Int J Impot Res 1992 4: 117–132

    Google Scholar 

  21. Hsu G-L et al. Anatomy and strength of the tunica albuginea: its relevance to penile prosthesis extrusion J Urol 1994 151: 1205–1208

    Article  CAS  PubMed  Google Scholar 

  22. Brock G et al. The anatomy of the tunica albuginea in the normal penis and in Peyronie's disease J Urol 1997 157: 276–281

    Article  CAS  PubMed  Google Scholar 

  23. Devine CJ . International Conference on Peyronie's Disease: Introduction J Urol 1997 157: 272–275

    Article  PubMed  Google Scholar 

  24. Gentile V et al. Ultrastructural and immunohistochemical characterization of the tunica albuginea in Peyronie's disease and veno-occlusive function J Androl 1996 17: 96–103

    CAS  PubMed  Google Scholar 

  25. Somers KD et al. Isolation and characterization of collagen in Peyronie's disease J Urol 1989 141: 629–631

    Article  CAS  PubMed  Google Scholar 

  26. Udelson D et al. Engineering analysis of penile hemodynamic and structural dynamic relationships: Part I. Clinical implications of penile tissue mechanical properties Int J Impot Res 1998 10: 15–24

    Article  CAS  PubMed  Google Scholar 

  27. Akkus E et al. Structural alterations in the tunica albuginea of the penis: impact of Peyronie's disease, ageing and impotence Br J Urol 1997 79: 47–53

    Article  CAS  PubMed  Google Scholar 

  28. van de Water L . Mechanisms by which fibrin and fibronectin appear in healing wounds: implications for Peyronie's disease J Urol 1997 157: 306–310

    Article  CAS  PubMed  Google Scholar 

  29. Somers KD, Dawson DM . Fibrin deposition in Peyronie's disease plaque J Urol 1997 157: 311–315

    Article  CAS  PubMed  Google Scholar 

  30. Border WA, Ruoslahti E . Transforming growth factor-β in disease: the dark side of tissue repair J Clin Inv 1992 90: 1–7

    Article  CAS  Google Scholar 

  31. Border WA, Noble NA . Transforming growth factor-β in tissue fibrosis N Engl J Med 1994 331: 1286–1291

    Article  CAS  PubMed  Google Scholar 

  32. Moreland RB . Is hypoxemia associated with penile fibrosis? Int J Impot Res 1998 10: 113–120

    Article  CAS  PubMed  Google Scholar 

  33. El-Sakka AI et al. Peyronie's disease is associated with an increase in transforming growth factor-beta protein expression J Urol 1997 158: 1391–1394

    Article  CAS  PubMed  Google Scholar 

  34. El-Sakka AI et al. An animal model of Peyronie's-like condition associated with an increase in transforming growth factor-beta mRNA and protein expression J Urol 1997 158: 2284–2290

    Article  CAS  PubMed  Google Scholar 

  35. El-Sakka AI et al. Histological and ultrastructural alterations in an animal model of Peyronie's disease Br J Urol 1998 81: 445–452

    Article  CAS  PubMed  Google Scholar 

  36. Poli G, Parola M . Oxidative damage and fibrogenesis Free Radical Biol. Med 1997 22: 287–305

    Article  CAS  Google Scholar 

  37. Scardino PL, Scott WW . The use of tocopherols in the treatment of Peyronie's disease Ann NY Acad Sci 1949 52: 390–394

    Article  Google Scholar 

  38. Zarafonetis CJD, Horran TM . Treatment of Peyronie's disease with potassium para-aminobenzoate (POTABA) J Urol 1959 81: 770–772

    Article  CAS  PubMed  Google Scholar 

  39. Bartsch G, Menander-Huber KB, Huber W, Marberger H . Orgotein, a new drug for the treatment of Peyronie's disease Eur J Rheumatol Inflamm 1981 4: 250–259

    CAS  PubMed  Google Scholar 

  40. Ludwig G . Evaluation of conservative therapeutic approaches to Peyronie's disease (fibrotic induration of the penis) Urol Int 1991 47: 236–239

    Article  CAS  PubMed  Google Scholar 

  41. Primus G . Orgotein in the treatment of plastic induration of the penis (Peyronie's disease) Int Urol Nephrol 1993 25: 169–172

    CAS  PubMed  Google Scholar 

  42. Lenk S, Schonberger B . Penile deviation-our therapeutic concept Acta Chir Hung 1994 34: 189–194

    CAS  PubMed  Google Scholar 

  43. Flohe L . Superoxide dismutase for therapeutic use: clinical experience, dead ends and hopes Mol Cell Biochem 1988 84: 123–131

    Article  CAS  PubMed  Google Scholar 

  44. Levine LA . Treatment of Peyronie's disease with intralesional verapamil injection J Urol 1997 158: 1395–1399

    Article  CAS  PubMed  Google Scholar 

  45. Rehman J, Benet A, Melman A . Use of intralesional verapamil to dissolve Peyronie's disease plaque: a long-term single blind study Urology 1998 51: 620–626

    Article  CAS  PubMed  Google Scholar 

  46. Akkus E et al. Is colchicine effective in Peyronie's disease? A pilot study Urology 1994 44: 291–295

    Article  CAS  PubMed  Google Scholar 

  47. Gelbard MK, James K, Riach P, Dorey F . Collagenase versus placebo in the treatment of Peyronie's disease: a double-blind study J Urol 1993 149: 56–58

    Article  CAS  PubMed  Google Scholar 

  48. Judge JS, Wisniewski ZS . Intralesional interferon in the treatment of Peyronie's disease: a pilot study Br J Urol 1997 79: 40–42

    Article  CAS  PubMed  Google Scholar 

  49. Polat O et al. Peyronie's disease: intralesional treatment with interferon alpha 2-A and evaluation of results by magnetic resonance imaging Int Urol Nephrol 1997 29: 465–471

    Article  CAS  PubMed  Google Scholar 

  50. Ralph DJ, Brooks MD, Botazzo GF, Pryor JP . The treatment of Peyronie's disease with tamoxifen Br J Urol 1992 70: 648–651

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology and Physiology, Boston University School of Medicine, Boston, Massachusetts, USA

    R B Moreland

  2. Mayo Clinic Foundation, Rochester, Minnesota, USA

    A Nehra

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  1. R B Moreland
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  2. A Nehra
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Correspondence to A Nehra.

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Moreland, R., Nehra, A. Pathophysiology of Peyronie's disease. Int J Impot Res 14, 406–410 (2002). https://doi.org/10.1038/sj.ijir.3900875

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