Volume 29 Issue 5, May 2022

Cover Credit:Gene augmentation restores retinal MAK protein expression, rescues primary cilia length, and prevents vision loss. A-C: Immunocytochemical analysis of primary cilia length in dermal fibroblasts obtained from a normal individual (A) and a patient with MAK-associated retinitis pigmentosa (B-C). Transduction with a clinical grade gene transfer vector carrying retinal MAK rescues the ability of patient cells to regulate the length of their primary cilia (C). D-G: Generation and treatment of MAK morphant zebrafish with retinal MAK transcript restores visually guided startle responses (G). See paper by Budd A. Tucker, et al. in this issue of Gene Therapy.