Volume 28 Issue 1-2, February 2021
Cover legend: Adeno-associated viral vector-mediated transduction of the corticospinal tract. Adeno-associated viral vectors (AAVs) are widely used as vehicles for gene transfer to the nervous system. The choice of promoter is an essential aspect of the design of AAVs. The image shows a coronal brain section of a rat injected with AAV1-SYN-eGFP in the right sensory-motor cortex. Transduction with AAV1 harbouring a human synapsin promoter leads to neuron-specific and strong transgene expression. The promoter comparison study by Nieuwenhuis et al., is now published in this issue of Gene Therapy.
Editorial
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