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Gene therapy in nonhuman primate models of human autoimmune disease

Gene Therapy volume 10, pages 890–901 (2003)Cite this article

Abstract

Before autoimmune diseases in humans can be treated with gene therapy, the safety and efficacy of the used vectors must be tested in valid experimental models. Monkeys, such as the rhesus macaque or the common marmoset, provide such models. This publication reviews the state of the art in monkey models for rheumatoid arthritis and multiple sclerosis and the (few) gene therapy experiments that have been performed in these models.

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Acknowledgements

We thank Dr Ronald Bontrop (BPRC), Dr JD Laman (Erasmus Medical Center Rotterdam) for critical reading of the manuscript, Dr Michel Vierboom for editing the manuscript, Mea van de Sman for secretarial assistance and Henk van Westbroek for the artwork. We are grateful to Professor Dr Tom Huizinga (LUMC, Leiden, The Netherlands) for providing Figure 2.

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Authors and Affiliations

  1. Department of Immunobiology, BPRC, Rijswijk, The Netherlands

    B A t'Hart

  2. Division of Clinical Immunology and Rheumatology, Department of Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands

    M Vervoordeldonk & P P Tak

  3. Department of Virology, BPRC, Rijswijk, The Netherlands

    J L Heeney

  4. ErasMS Centre for MS Patient Care, Research and Expertise, Rotterdam, Rijswijk, The Netherlands

    B A t'Hart

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t'Hart, B., Vervoordeldonk, M., Heeney, J. et al. Gene therapy in nonhuman primate models of human autoimmune disease. Gene Ther 10, 890–901 (2003). https://doi.org/10.1038/sj.gt.3302017

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