Figure 5 - Cyclooxygenase or lipoxygenase inhibitors and LES basal tone.

From the following article

Signal transduction in lower esophageal sphincter circular muscle

Piero Biancani and Karen M. Harnett

GI Motility online (2006)



LES circular muscle strips were incubated in the lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) or the cyclooxygenase inhibitor indomethacin (Indo), alone or in the presence of tetrodotoxin (TTX) 10-4 M. NDGA had no effect. Indomethacin caused a concentration-dependent reduction in LES basal tone that was not affected by tetrodotoxin. These data suggest that prostaglandins, and not leukotrienes, play a role in LES basal tone and that prostaglandins may not come from nerve terminals. Values are mean plusminus SE of three to seven animals. (Source: Cao et al.,15 with permission from the American Physiological Society.)

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