GI Motility Online

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From the following article

Signal transduction in lower esophageal sphincter circular muscle

Piero Biancani and Karen M. Harnett

GI Motility online (2006)

doi:10.1038/gimo24

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Figure 1

Signal transduction for lower esophageal sphincter (LES) contraction in response to agonists.

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Figure 2

Signal transduction for LES tone.

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Figure 3

[3H]Arachidonic acid (AA) content and release of LES and esophageal circular smooth muscle.

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Figure 4

Secreted phospholipase A2 (sPLA2) inhibitors and [3H]AA release and LES tone.

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Figure 5

Cyclooxygenase or lipoxygenase inhibitors and LES basal tone.

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Figure 6

Prostaglandin F2alpha (PGF2alpha)-induced protein kinase C (PKC) activation in LES tone and sustained contraction.

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Figure 7

RhoA in LES tone and PGF2alpha-induced sustained contraction.

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Figure 8

Mitogen-activated protein (MAP) kinases mediate PKC-dependent LES basal tone.

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Figure 9

Protein kinase C (PKC)-mediated contraction of LES circular muscle.

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Figure 10

H2O2 and LES.

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Figure 11

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in esophagitis.

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Figure 12

An in vitro model of esophagitis.

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Figure 13

H2O2 in LES epithelial and circular muscle cells.

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Figure 14

Release of H2O2 in mucosa supernatant.

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